biomimetic coupling
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2020 ◽  
Vol 121 ◽  
pp. 105786 ◽  
Author(s):  
Yuhuan Yuan ◽  
Guoping Zhao ◽  
Peng Zhang ◽  
Hong Zhou


2019 ◽  
Vol 6 (19) ◽  
pp. 1900864 ◽  
Author(s):  
Xinlin Li ◽  
Guoyong Wang ◽  
Bin Zhan ◽  
Shuyi Li ◽  
Zhiwu Han ◽  
...  
Keyword(s):  


2016 ◽  
Vol 32 (2) ◽  
pp. 343-353 ◽  
Author(s):  
Qi Sui ◽  
Hong Zhou ◽  
Haifeng Zhang ◽  
Li Feng ◽  
Lin Yang ◽  
...  

Abstract





2014 ◽  
Vol 19 (9) ◽  
pp. 1282-1289 ◽  
Author(s):  
Giuseppina Basini ◽  
Carmela Spatafora ◽  
Corrado Tringali ◽  
Simona Bussolati ◽  
Francesca Grasselli

In the ongoing search for new therapeutic compounds, lignans and neolignans, which are widely distributed in plants, deserve special attention because of their interactions with several biological targets. Searching for potential antiangiogenic agents related to natural lignans/neolignans, we were attracted by a previously studied synthetic dihydrobenzofuran neolignan. We synthesized the compound by means of an eco-friendly, enzyme-mediated biomimetic coupling of the methyl ester of ferulic acid, and the present study was aimed to deeply investigate its effect in angiogenesis bioassays validated in our laboratory. In addition, a previously well-defined granulosa cell model was employed to evaluate the effect of dihydrobenzofuran neolignan on cell viability, steroidogenesis, and redox status. Present data support the antiangiogenic effect of this neolignan. Moreover, we demonstrate that, at least at the highest concentrations tested, dihydrobenzofuran neolignan affects granulosa cell viability and steroidogenesis. In addition, the compound inhibits generation of free radicals and stimulates scavenger enzyme activities. The present data, which are a further deepening of the evaluation of the biological activities of the dihydrobenzofuran lignan in well-defined cell models, are of interest and worthy of special attention.





2013 ◽  
Vol 11 (35) ◽  
pp. 5885 ◽  
Author(s):  
Emerson Giovanelli ◽  
Lionel Moisan ◽  
Sébastien Comesse ◽  
Sébastien Leroux ◽  
Bernard Rousseau ◽  
...  
Keyword(s):  


2012 ◽  
Vol 19 (4) ◽  
pp. 1170-1173 ◽  
Author(s):  
Emerson Giovanelli ◽  
Lionel Moisan ◽  
Sébastien Leroux ◽  
Sébastien Comesse ◽  
Bernard Rousseau ◽  
...  
Keyword(s):  


2012 ◽  
Vol 22 (10) ◽  
pp. 3485-3487 ◽  
Author(s):  
Weibin Song ◽  
Lingjun Hu ◽  
Yuhui Meng ◽  
Lei Ma ◽  
Dean Guo ◽  
...  


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