Methods, models, mechanisms and metadata: Introducing the Nanotoxicology collection at F1000Research

Nanotoxicology is a relatively new field of research concerning the study and application of nanomaterials to evaluate the potential for harmful effects in parallel with the development of applications. Nanotoxicology as a field spans materials synthesis and characterisation, assessment of fate and behaviour, exposure science, toxicology / ecotoxicology, molecular biology and toxicogenomics, epidemiology, safe and sustainable by design approaches, and chemoinformatics and nanoinformatics, thus requiring scientists to work collaboratively, often outside their core expertise area. This interdisciplinarity can lead to challenges in terms of interpretation and reporting, and calls for a platform for sharing of best-practice in nanotoxicology research. The F1000Research Nanotoxicology collection, introduced via this editorial, will provide a place to share accumulated best practice, via original research reports including no-effects studies, protocols and methods papers, software reports and living systematic reviews, which can be updated as new knowledge emerges or as the domain of applicability of the method, model or software is expanded. This editorial introduces the Nanotoxicology Collection in F1000Research. The aim of the collection is to provide an open access platform for nanotoxicology researchers, to support an improved culture of data sharing and documentation of evolving protocols, biological and computational models, software tools and datasets, that can be applied and built upon to develop predictive models and move towards in silico nanotoxicology and nanoinformatics. Submissions will be assessed for fit to the collection and subjected to the F1000Research open peer review process.

Enhancing the use of exposure science across EU chemical policies as part of the European Exposure Science Strategy 2020–2030

Background A scientific framework on exposure science will boost the multiuse of exposure knowledge across EU chemicals-related policies and improve risk assessment, risk management and communication across EU safety, security and sustainability domains. Objective To stimulate public and private actors to align and strengthen the cross-policy adoption of exposure assessment data, methods and tools across EU legislation. Methods By mapping and analysing the EU regulatory landscape making use of exposure information, policy and research challenges and key areas of action are identified and translated into opportunities enhancing policy and scientific efficiency. Results Identified key areas of actions are to develop a common scientific exposure assessment framework, supported by baseline acceptance criteria and a shared knowledge base enhancing exchangeability and acceptability of exposure knowledge within and across EU chemicals-related policies. Furthermore, such framework will improve communication and management across EU chemical safety, security and sustainability policies comprising sourcing, manufacturing and global trade of goods and waste management. In support of building such a common framework and its effective use in policy and industry, exposure science innovation needs to be better embedded along the whole policymaking cycle, and be integrated into companies’ safety and sustainability management systems. This will help to systemically improve regulatory risk management practices. Significance This paper constitutes an important step towards the implementation of the EU Green Deal and its underlying policy strategies, such as the Chemicals Strategy for Sustainability.

Key considerations for assessing soil ingestion exposures among agricultural workers

Background Soil ingestion is a critical, yet poorly characterized route of exposure to contaminants, particularly for agricultural workers who have frequent, direct contact with soil. Objective This qualitative investigation aims to identify and characterize key considerations for translating agricultural workers’ soil ingestion experiences into recommendations to improve traditional exposure science tools for estimating soil ingestion. Methods We conducted qualitative in-depth interviews with 16 fruit and vegetable growers in Maryland to characterize their behaviors and concerns regarding soil contact in order to characterize the nature of soil ingestion in the agricultural context. Results We identified and discussed four emergent themes: (1) variability in growers’ descriptions of soil and dust, (2) variability in growers’ soil contact, (3) growers’ concerns regarding soil contact, (4) growers’ practices to modify soil contact. We also identified environmental and behavioral factors and six specific agricultural tasks that may impact soil ingestion rates. Significance Our investigation fills an important gap in occupational exposure science methodology by providing four key considerations that should be integrated into indirect measurement tools for estimating soil ingestion rates in the agricultural context. Specifically, a task-based framework may provide a structure for future investigations of soil contact that may be useful in other populations.

Assessing the exposure and hazard of diesel exhaust in professional drivers: a review of the current state of knowledge

It is well-established that traffic-related air pollution has a detrimental impact on health. Much of the focus has been on diesel exhaust emissions due to a rapid increase in vehicle numbers and studies finding that this pollutant is carcinogenic. Unsurprisingly, the highest diesel exposures that the general population experiences are during urban daily commutes; however, few studies have considered professional drivers who are chronically exposed to the pollutant due to their work in transport microenvironments. In this narrative review, we address the literature on professional drivers’ exposure to diesel exhaust and advocate that a modern exposure science approach utilised in commuter personal exposure studies is needed. This type of evaluation will provide a more detailed understanding of the time-activity of professional drivers’ exposures which is required to identify specific interventions to reduce their risk to diesel exhaust emissions.

Feasibility Evaluation of CFD Approach for Inhalation Exposure Assessment: Case Study for Biocide Spray

Consumer products contain the chemical substances that threaten human health. The modeling methods and experimental methods have been used to estimate the inhalation exposure concentration by the consumer products. The model and measurement methods have the spatial property problem and time/cost consuming problem, respectively. For solving the problems due to the conventional methodology, this study performed the feasibility of applying CFD for evaluation of inhalation exposure by comparing the experiment results and the zero-dimensional results with CFD results. To calculate the aerosol concentration, the CFD was performed by combined the 3D Reynolds averaged Navier Stoke’s equation and discrete phased model using ANSYS FLUENT. As a result of comparing the three methodologies performed under the same simulation/experimental conditions, we found the zero-dimensional spray model shows approximately 5 times underestimated inhalation exposure concentration when compared with the CFD results and measurement results in near field. Also, the results of the measured concentration of aerosols at five locations and the CFD results at the same location were compared to show the possibility of evaluating inhalation exposure at various locations using CFD instead of experimental method. The CFD results according to measurement positions can predict rationally the measurement results with low error. In conclusion, in the field of exposure science, a guideline for exposure evaluation using CFD was found that complements the shortcomings of the conventional methodology, the zero-dimensional spray model and measurement method.

Emerging investigator series: The role of chemical properties in human exposure to environmental chemicals

One of the ultimate goals of environmental exposure science is to mechanistically understand how chemical properties and human behavior interactively determine human exposure to the wide spectrum of chemicals present...