Carcinoma Cuniculatum with Bone Invasion Mimicking a Viral Wart

Carcinoma cuniculatum is a rare variant of low-grade and well-differentiated squamous cell carcinoma. It is a locally invasive tumor, although it has low metastatic potential. It was originally described in the plantar region but may exceptionally appear in other locations. It predominates in middle-aged men and presents clinically as an exophytic, solitary, painful tumor, with insidious growth. Histologically, this tumor simulates a variety of benign dermatoses and may require several biopsies for the correct diagnosis. It is often misdiagnosed as a viral wart, due to the clinical similarity and the indolent course. The treatment of choice is surgical excision due to the high risk of recurrence and locally aggressive behavior. Amputation can be performed in cases of deep tissue invasion. We present a case of carcinoma cuniculatum in which the late diagnosis favored the invasion of the underlying bone, resulting in amputation of the affected finger.

Response of Bowenoid Papulosis to Combination Treatment of Oral Isotretinoin and Topical 1% 5-Fluorouracil

Bowenoid papulosis (BP) is a rare benign disease which can have spontaneous regression but can sometimes turn malignant.1 It is characterised by solitary or multiple verruca-like papules or plaques usually present on genitalia having a close histological resemblance to Bowen's disease and a predilection for sexually active young adults.2 It affects all races equally and has almost same male to female ratio. There are an estimated 5 cases per 100000 women. The exact prevalence is unknown.3 We hereby present a case report of bowenoid papulosis. Bowenoid papulosis is an uncommon form of intraepithelial neoplasia. It is caused by human papilloma virus (HPV) infection and clinically resembles viral wart while histologically resembling in situ squamous cell carcinoma (SCC). We hereby report a case of an adult male with multiple verrucous lesions on penis and scrotum. The histopathology showed features of bowenoid papulosis. The patient was treated with oral isotretinoin and topical 1 % 5 - fluorouracil following which the lesions reduced remarkably in the span of 3 weeks.

Evaluation of Atopic Dermatitis and Infectious Disorders Using Sequential Pattern Mining

Atopic dermatitis (AD) is a chronic inflammatory skin disease related with abnormal immune response and epidermal barrier function impairment. The aim of our study was to estimate the association between AD and infectious disorders in real world. We analyzed population-based data from 2010 to 2013 using National Health Insurance Service. Sequential pattern mining (SPM) was used to identify comorbid infectious diseases and onset duration of the comorbidities. Patients with AD were at higher risk for molluscum contagiosum (adjusted odd ratio (aOR) 5.273), impetigo (aOR 2.852), chicken pox (aOR 2.251) and otitis media (aOR 1.748), eczema herpeticum (aOR 1.292), viral wart (aOR 1.105). Our study suggests that AD is associated with increased risk of infectious disorders. In particular, care should be taken for early diagnosis of comorbidity and appropriate management.

Nail changes

Nail disease in children is relatively uncommon, save for some classic patterns relating to trauma, such as ingrowing nails and nail biting. Inflammatory diseases are typically eczema or psoriasis, or inflammatory dermatoses complicated by infection in the form of paronychia. Infection alone is not common and fungus, less in children than adults. Some rare genodermatoses can present with characteristic features in the nails and can be early clues to longer-term diseases. Benign tumours cross the range of categories, with viral wart infection, benign fibromas of tuberose sclerosis and bone tumours such as exostoses.

Subungual Exostosis in a Young Soccer Player

BACKGROUND: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis.CASE REPORT: We report a rare case of subungual exostosis of the great toe associated with repeated trauma of the nail bed. The lack of radiographic and histopathological examination could lead to misdiagnosis and inadequate treatment. Although completely benign, subungual exostosis should be considered in differential diagnosis of nail bed tumors in young adults, in order to avoid associated complications and unneeded aggressive surgical interventions.CONCLUSION: Complete excision of the lesion and delicate separation from the underlying nail bed structures results in total resolve of the problem, by providing the lowest risk of recurrences.