scholarly journals Response of Bowenoid Papulosis to Combination Treatment of Oral Isotretinoin and Topical 1% 5-Fluorouracil

2021 ◽  
Vol 10 (35) ◽  
pp. 3067-3069
Author(s):  
Shravya Rimmalapudi ◽  
Sugat Jawade ◽  
Bhushan Madke ◽  
Adarsh Lata Singh
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Sexually Active ◽  
Female Ratio ◽  
Papilloma Virus ◽  
Bowenoid Papulosis ◽  
Oral Isotretinoin ◽  
Viral Wart ◽  
Male To Female

Bowenoid papulosis (BP) is a rare benign disease which can have spontaneous regression but can sometimes turn malignant.1 It is characterised by solitary or multiple verruca-like papules or plaques usually present on genitalia having a close histological resemblance to Bowen's disease and a predilection for sexually active young adults.2 It affects all races equally and has almost same male to female ratio. There are an estimated 5 cases per 100000 women. The exact prevalence is unknown.3 We hereby present a case report of bowenoid papulosis. Bowenoid papulosis is an uncommon form of intraepithelial neoplasia. It is caused by human papilloma virus (HPV) infection and clinically resembles viral wart while histologically resembling in situ squamous cell carcinoma (SCC). We hereby report a case of an adult male with multiple verrucous lesions on penis and scrotum. The histopathology showed features of bowenoid papulosis. The patient was treated with oral isotretinoin and topical 1 % 5 - fluorouracil following which the lesions reduced remarkably in the span of 3 weeks.

A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus

1990 ◽  
Vol 48 (3) ◽  
pp. 204-205
Author(s):  
Kun Lee ◽  
Jingyi Si ◽  
Ricai Han ◽  
Wei Zhang ◽  
Bingbing Tan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Dot Blot ◽  
Homologous Sequences ◽  
Normal Cervical Epithelium ◽  
The Relationship ◽  
Chronic Cervicitis

There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-DNA hybridizations by using HPV-11, 16, 18 DNA labelled with 32P and 3H as probes to detect viral homologous sequences in samples. Among them, 32 cases with cervical cancer, 27 with condyloma and 10 normal cervical epitheliums were randomly chosen for comparative EM observation. The results showed that: 1), 192 out of 318 (60.4%) cases of cervical cancer were positive for HPV-16 DNA probe (Table I)

‘Abnormal’ Papanicolaou smears and colposcopy in pregnancy: ante- and post-partum findings

1993 ◽  
Vol 3 (4) ◽  
pp. 239-244 ◽  
Author(s):  
W. A. Nahhas ◽  
M. A. Clark ◽  
M. Brown
Keyword(s):  
Post Partum ◽  
Condylomata Acuminata ◽  
Intraepithelial Neoplasia ◽  
Genital Warts ◽  
Hpv Infection ◽  
Partial Regression ◽  
Abnormal Cytology ◽  
Papilloma Virus ◽  
Cytologic Smear ◽  
Papanicolaou Smears

Abnormal Papanicolaou smears and colposcopic findings suggesting human Papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) may occur during pregnancy. Condylomata acuminata often grow rapidly during pregnancy and may regress spontaneously following delivery. However, the post-partum outcome of the untreated ante-partum abnormal cytologic smear and colposcopy has not been defined clearly. Seventy-three pregnant patients were examined by colposcopy because of genital warts and/or abnormal Papanicolaou smears. Cytologic, colposcopic and histologic re-evaluation was conducted after delivery. Only one of the patients had a normal ante-partum colposcopic examination. This number increased to 15 after delivery. Forty-one patients had normal post-partum cytologic smears, but only 13 had normal histology. Abnormal post-partum cytology was highly predictive of abnormal colposcopy and histology. In contrast, normal post-partum cytology was not very accurate in predicting normal colposcopy and histology. It is concluded that a few pregnant patients may have partial regression of clinical HPV infection and abnormal cytology and colposcopy after delivery. However, the majority will continue to have abnormal findings 4 months following delivery in spite of normal post-partum cytology and even colposcopy.

scholarly journals Significance of molecular diagnostics in human papilloma virus (HPV) determination

2014 ◽  
Vol 66 (1) ◽  
pp. 51-56 ◽  
Author(s):  
G. Kovacevic ◽  
V. Milosevic ◽  
I. Hrnjakovic-Cvjetkovic ◽  
V. Petrovic ◽  
S. Stefan-Mikic ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
Molecular Techniques ◽  
Etiologic Factor ◽  
Abnormal Cytology ◽  
Normal Cytology ◽  
Papilloma Virus ◽  
Cervical Cancer Development ◽  
High Risk Hpv

HPV infection is considered to be the most important etiologic factor in cervical cancer development. In this retrospective study, which included the period from 2000 to 2012, the results of two molecular techniques used in the detection of HPV infection among women of the South Backa District were analyzed. By using the technique of in situ hybridization and the rPCR method, the proportion of high-risk HPV among women with normal cytology was determined to be 19.8% and 32.7%, respectively, and among women with abnormal cytology 43.1% and 61%, respectively. Among the analyzed women, HPV type 16 was the most prevalent, followed by HPV types 31, 51 and 18. Application of molecular HPV diagnosis is valuable because it increases the sensitivity of the screening test, so that the application of both tests to detect cervical cancer is a true prevention of malignancy.

scholarly journals Multiple HPV-Induced Squamous Cell Carcinomas on the Fingers of a Patient with Systemic Lupus Erythematosus: A Case and Review

2015 ◽  
Vol 7 (3) ◽  
pp. 329-334 ◽  
Author(s):  
Georgios Nikolakis ◽  
Ioannis Karagiannidis ◽  
Vasiliki A. Zampeli ◽  
Andreas Altenburg ◽  
Martina Brunner ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Squamous Cell ◽  
Lupus Erythematosus ◽  
Hpv Vaccination ◽  
Hpv Infection ◽  
High Risk Group ◽  
Squamous Cell Carcinomas ◽  
Systemic Lupus ◽  
Papilloma Virus

Human papilloma virus (HPV) infection is documented to be involved in the development of epithelial malignancies, mostly in cervical cancer. Systemic lupus erythematosus (SLE) patients have an increased prevalence of such an infection. We report the case of a 55-year-old female SLE patient who developed multiple in situ squamous cell carcinomas on her fingers, after chronic HPV infection. HPV-33 DNA was isolated from the lesions. The purpose of this case presentation is to raise awareness about HPV-induced malignancies for this high-risk group and propose an early HPV vaccination to efficiently prevent such comorbidities.

Human papilloma virus: from understanding of immunopathogenesis to rational tactics of management

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 5-11 ◽  
Author(s):  
A L Tikhomirov ◽  
S I Sarsaniya ◽  
G A Filatova
Keyword(s):  
Human Papilloma Virus ◽  
Sexually Transmitted Infection ◽  
Hpv Infection ◽  
Sexually Active ◽  
Transmitted Infection ◽  
Papilloma Virus ◽  
Sexually Transmitted ◽  
Active Population ◽  
The World ◽  
Epithelial Lesions

The human papilloma virus (HPV) is the most common sexually transmitted infection. 440 million people in the world suffer from HPV infection of the genital. During the life of HPV, 50 to 80% of the sexually active population is infected, most often in the first years of sexual activity (the maximum prevalence is between 18-30 years of age). The treatment of subclinical forms of HPV epithelial lesions in 115 patients aged 26 to 42 years with a normal colposcopic pattern and the presence of coilocytosis was performed.

scholarly journals Determination of papilloma-virus infection reproductive phase in algorithm of monitoring patients with cervical displasia

2021 ◽  
Vol 51 (4) ◽  
pp. 61-63
Author(s):  
S. A. Selkov ◽  
G. N. Vedeneeva ◽  
I. A. Baskakova ◽  
S. R. Baur
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Hpv Dna ◽  
Virus Activity ◽  
Polymerase Chain

HPV 16 and 18 are known to be the main cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The terms of HPV persistence in the host and, coordinately, the risk of cervical neoplasia development and progression are determined in much extent by virus activity. The purpose of this investigation was the detection of HPV DNA presence in cervical epithelium as well as confirmation of its activity by means of immunocytochemistry and reverse transcriptase polymerase chain reaction. The level of HPV inf ection by oncogenic and nononcogenic types in 181 women with different cervical pathology was 55,8%. The active stage of HPV infection was confirmed in 27,5% of HPV-inf ected women mainly with low grades of CIN. The proof of reproductive general HPV infection was more informative with RT PCR just as for HPV 16 and 18 immunocytochemistry and RT PCR completed each anothe.

scholarly journals A direct comparison of four high risk human papilloma virus tests versus the cobas test for detecting cervical intraepithelial neoplasia and cervical cancer

2018 ◽  
Author(s):  
Peng Xue ◽  
Li-Li Gao ◽  
Jian Yin ◽  
Li-Li Han ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Cervical Intraepithelial Neoplasia ◽  
Clinical Decision Making ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Cervical Intraepithelial Neoplasia Grade ◽  
Papilloma Virus ◽  
Clinical Sensitivity ◽  
Detection Techniques ◽  
Hpv Genotyping

ABSTRACTThis study is to evaluate performances and genotyping capabilities of four human papilloma virus (HR-HPV) tests based on real-time polymerase chain reaction (PCR) technology platforms compared with the cobas test. Discordant results were further analyzed using INNO-LiPA HPV genotyping test, the gold standard laboratory test to determine presence and type of HPV infection. Over 200 samples from Hospital patients were collected and analyzed using five HR-HPV tests. Women with positive test results were referred directly to colposcopy. If a positive result was returned, biopsies were administered for pathological classification. Clinical performances and genotyping capabilities between the four HR-HPV and cobas tests were compared and contrasted. High levels of agreement were observed, though all HR-HPV tests presented discrepancies compared with the cobas test. Cervical intraepithelial neoplasia Grade 2 or higher lesions (CIN2+) was set as the threshold, and all five tests performed with equally high sensitivity. Lower levels of specificity were observed across all five tests. Results suggest the four HR-HPV tests analyzed are as effective as the cobas test in genotyping capacities and diagnosing CIN. Therefore, these test kits should be used for HPV screening, especially in developing nations because they are cost effective and reliable. Minor discrepancies between tests are generally unavoidable though this may add complexity to the clinical decision-making process. As such, we recommend that efforts be made to standardize HPV genotyping tests as well as to optimize clinical sensitivity and specificity. Focusing on these issues will drive the development of HPV detection techniques, therefore save lives.

scholarly journals Potential Prognostic Significance of Patterns of Deletion (13q) in Plasma Cell Myelomas—Reappraisal of a Perennial Bone of Contention

2021 ◽  
Vol 42 (03) ◽  
pp. 297-300
Author(s):  
Mohit Kumar Bhardwaj ◽  
Beklashwar Salona ◽  
Sambit Kumar Mohanty
Keyword(s):  
Survival Data ◽  
Prognostic Significance ◽  
Progression Free Survival ◽  
Interstitial Deletion ◽  
Terminal Deletion ◽  
Female Ratio ◽  
Free Survival ◽  
Male To Female

AbstractDeletion 13q is recommended in the initial cytogenetic workup of myeloma patients. The patterns of this abnormality have been shown to have differential prognostic value. The presence of monosomy 13 is associated with a significantly poor progression-free survival, while interstitial deletion 13q is associated with significant improvement in the overall survival. We analyzed the patterns of 13q abnormalities on fluorescent in situ hybridization (FISH) assay results in myeloma patients. Deletion 13q abnormalities were observed in 38% (55 of 138) of the myeloma patients. Ten (18%) and 44 (80%) patients showed interstitial deletion and terminal deletion, respectively. One had a mosaic of both the patterns. Nine of the ten patients with interstitial deletions were males. For terminal deletion 13q, there appeared to be a slight female predilection, with a male to female ratio of 0.83:1. Half of the patients with deletion 13q had coexistent cytogenetic abnormalities. We suggest a baseline FISH for deletion 13q and specification of the type of abnormality (terminal vs. interstitial) in patients with myeloma. Based on our observation in conjunction with the available literature, further studies in a large cohort of patients with survival data are warranted to clearly delineate the role of deletion 13q in myeloma.

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