Harnessing novel data sources to understand patients’ perspectives (Preprint)

UNSTRUCTURED Patient perspectives are central to the U.S. Food and Drug Administration’s benefit-risk decision-making process in the evaluation of medical products. Traditional channels of communication may not be comfortable for all patients and consumers. Social media websites have increasingly been recognized by researchers as a means to gain insights on patients’ views about treatment and diagnostic options, the healthcare system, and their experiences living with their conditions. Utilizing multiple patient perspective data sources offers the FDA the opportunity to capture diverse patient voices and experiences with chronic pain. The FDA Office of Minority Health and Health Equity (OMHHE) and the Center for Devices and Radiological Health (CDRH) worked with INSPIRE (Clinica Health, Inc.) to conduct a pilot study exploring posts from INSPIRE’s own patient platform and several social media platforms to gain insights into the key challenges and barriers faced by chronic pain patients (CPPs). The most common topics discussed among CPPs were disease burden, support and advocacy needs, and proper diagnosis. The two most frequently discussed treatments were opioids or narcotics, and devices such as transcutaneous electrical nerve stimulation (TENS) machines and spinal cord stimulators. Success in pain reduction was tempered by concerns of stigmatization regarding opioid addiction and dependency. The study illustrates how social listening data may provide valuable insights into diverse patient perspectives, preferences, and unmet needs, especially for conditions that may be perceived as stigmatizing.

Teresterial Background Ionizing Radiation around Lead/Zinc Mining Site in Ishiagu, Ebonyi State, Nigeria

Background ionizing radiation around Lead/Zinc mining sites at Ishiagu, Ebonyi State was carried out using appropriate equipment. The background ionizing radiation of the environment was determined by measuring the radiation exposure rates using Radalert-200 and Geographical Positioning System (GPS). Radiological health parameters and effective dose to different organs of the body was estimated. The average exposure rate of 0.00017mSv/h (0.017mR/h) measured was relatively higher than the world acceptable value of 0.00013mSv/h (0.013mR/h ). All the radiological risk parameters estimated are relatively high. The result of this work shows that the mining µactivities have enhanced the radiation level of Ishiagu and health status of the populace.

Assessment of Activity Concentration of Radionuclides in Soil and Cassava Food Crop from Solid Mineral Mining Site in Ishiagu, Ivo L.G.A of Ebonyi State, Nigeria

The assessment of activity of concentration of radionuclides in soil and food crops from solid mineral mining sites at Ishiagu, in Ivo L.G.A of Ebonyi State was carried out using the necessary measuring instruments. Samples of soil and cassava crop collected from around the mining sites. The samples were analysed using gamma ray spectrometry. The average activity concentration of 226Ra, 232Th and 40K in soil samples were 12.37,16.08, and 144.29 Bqkg-1 while those for cassava were 2.81, 16.80, and 205.41 Bqkg-1. The soil/plant radionuclide transfer ratio estimated are 0.62, 2.43 and 2.51 for 226Ra, 232Th and 40K, respectively. All the radiological risk parameters estimated are relatively low. The result of this work showed that the obtained results for all samples were lower than the international accepted limit. Hence, from radiological health standpoint, the obtained values of effective doses may not pose significant threat to both human and the environment.

Soil to Cassava Transfer Factors of Natural Radionuclides in Farms in Ini Local Government Area, Akwa Ibom State, Nigeria

Knowledge of activity concentration of radionuclides in soil of our farmlands and the consequent transfer factors of the radionuclide to plants are necessary to estimate the contamination level of the soil, plants and food. The activity concentration of 40K, 238U and 232Th in soils and cassava in Ini Local Government Area, Akwa Ibom State, Nigeria were measured using gamma spectrometry. Activity concentrations of radionuclides in soils in the locations ranged from BDL (below detectable limit) to 298.76 ± 21.40 Bq/Kg for 40K; BDL to 7.95 ± 1.88 Bq/Kg for 238U and 2.59 ± 0.25 to 16.56 ± 1.61 Bq/Kg for 232Th. Activity concentration of the radionuclides in cassava in all locations ranged from 213.96 ± 15.38 Bq/kg to 520.58 ± 37.25 Bq//Kg for 40K; BDL to 33.02 ± 8.91 Bg/Kg for 238U and BDL to 16.34 ± 1.59 Bq/kg for 232Th. The activity concentrations of all the radionuclides were lower than the world standard. Transfer factors obtained ranged between 3.21 to 4.18 for 40K; 0.93 to 12.64 for 238U and 0.75 to 1.01 for 232Th. Effective ingestion dose due to the consumption of cassava from the studied area obtained ranged between 1.31 to 1.74 mSv/yr and 3.52 to 4.69 mSv/yr for children and adult respectively. These values are above the 1.0 mSv/yr recommended dose limit for general public, therefore the consumption of this food stuff could pose a radiological health effect on humans. However the risk could be minimized when the cassava is cooked.

Determination of Activity Concentrations and Soil to Cassava Transfer Factors of Natural Radionuclides in Ikot Ekpene Local Government Area, Akwa Ibom State, Nigeria

Natural radioactivity exists in primordial formations such as rocks, soils, water and air where long lived radionuclides such as , , and their affiliates are found. This work was done to determine the specific activity of radionuclides, soil to cassava transfer factor and the effective dose due to consumption of radionuclide in cassava products in Ikot Ekpene Local Government Area, Akwa Ibom State. The specific activity of 40K, 238U and 232Th in soils and cassava in the study area was measured using gamma spectrometry. Mean specific activity in soils ranged from BDL to 153.46 ± 10. 99 Bq/Kg for 40K; BDL to 31. 22 ± 7.49 Bq/Kg for 238U and 1.03 ± 0.10 to 12.71 ± 1.24 Bq/Kg for 232Th. Mean specific activity of the radionuclides in cassava in all locations ranged from 119.86 ± 8.61 to 601.28 ± 43.23 Bq//Kg for 40K; below detectable limit (BDL) to 15. 89 ± 1.55 Bg/Kg for 238U and BDL to 15. 89 ± 1.55 Bq/kg for 232Th. Transfer factors ranged between 3.64 to 4.18 for 40K; 1.30 to 1.82 for 238U and 0.51 to 0.72 for 232Th. Effective ingestion dose due to the consumption of cassava from the area ranged between 0.99 mSv/yr to 1.08 mSv/yr and 2.68 mSv/yr to 29.16 mSv/yr for children and adult respectively. Most of the TF and effective ingestion dose results for this study were above the recommended value of unity which suggests that consumption of cassava from the studied area may pose radiological health.

ASSESSMENT OF RADON CONCENTRATIONS IN WATER SOURCES FROM SABON GARI LOCAL GOVERNMENT AREA, KADUNA STATE, NIGERIA

Radon concentration in water is one of the major problems of radiation protection in recent years. This work assessed the radon concentration in water sources from Sabon Gari, local government area, Kaduna State. The water samples were collected and analyzed using Liquid scintillation counter (Tri-Carb-LSA1000). The overall mean radon concentration of the waters samples was found to be 14.9 BqL-1, which is higher than the maximum permissible limit of 11.1 BqL-1 by USEPA and the world average value of 10 BqL-1 by UNSCEAR and WHO. The overall Annual effective dose (AED) due to inhalation of radon is calculated to be 37.6 μSvy-1. This value is less than the permissible limit of 100 μSvy-1 set by WHO. Also, the overall AED due to ingestion is estimated as 109.0, 154.2, and 180.4 μSvy-1 respectively for both Adult, children and Infant, which is slightly higher than the WHO permissible limit of 100 μSvy-1 for adults and less than the permissible limit of 200 μSvy-1 for children. This result shows that the inhabitants of Sabon Gari local government are safe from any radiological health related effects that may result from the inhalation of radon gas. Also, both Children and Infant are safe from any immediate radiological health risk, but for Adults, consuming any of the water sources (Well, Borehole and Surface) over a prolong period of time is not completely safe and may result in radiological health hazard

Assimilation of natural Radionuclides in the wheat plant from cultivated soil

The intake of naturally nuclides 238U, 232Th, and 40K by wheat crop from two different fertilization soils of Iraq was studied under natural farm conditions. The overall mean of soil to wheat cereal transfer factors (TF) was studied and observed to be in the range of 0.6 × 10-3 to 0.70 × 10-3 for 238U, 0.11 × 10-3 to 0.13 × 10-3 for 232Th and 0.054 to 0.055 for 40K. The calculated values of TF for wheat grain denote that 40K are the significant radionuclides that are transferred in grain. This evaluation is most important for the production of foodstuffs with low contents of radionuclides. The assimilation of radionuclides by consuming wheat cereals from the farms studied gives a small fraction to the total annual ingestion dose received by a person due to naturally existent radioactivity material in the environment. This study proves that the natural radioactivity and Ingestion effective dose was lower than the safe, which the total of the dose received from 238U and 232Th due to consumption of wheat grains alone from fertilized field 0.056 and 0.045 mSv y-1 from the unfertilized field total ingestion dose, the dose received from 40K due to the consumption from the unfertilized and fertilized field was 0.0102 and 0.0137 respectively. The dose values were less than the limit value of 0.30 mSv y-1. Therefore, the consumption of these foods has no health risks. This process may help to obtain basics on radiological health regulations The activity concentration of natural radionuclides 238U, 232Th, and 40K in fertilized and unfertilized soil and wheat plants growing into is statistically significant at 1% level of significance using an independent t-test.

Determination of Natural Radioactivity and Radiological Hazard Associated with Sediments Sourced from Ogunpa River Channels, Ibadan, Nigeria

The natural radionuclides content and radiological assessment of sediments of the Ogunpa waste-water channel were evaluated to ascertain the radiological safety of the sediments as a building material. The mean activity concentrations of 40K, 226Ra and 232Th in Bq kg−1 were found to be 171 ± 69, 11 ± 5 and 10 ± 4, respectively. The overall mean radium equivalent 29 ± 13 Bq kg−1 was <370 Bq kg−1 that can give the maximum recommended dose of 1 mSv to the general public. The activity concentrations of the radionuclides were all less than world average for soils and sediments. Thus, the use of the sediments from the Ogunpa water channel as building material is safe and would not pose any significant radiological health hazards.