AbstractA pharmacy in a comprehensive cancer center needs to be cognizant of new and emerging models of care that are integrated and patient-centered, attentive to cutting edge research, cancer treatment and different approaches to managing the entire spectrum of oncological care. Hence, the focus of pharmacy services should be on care deliverance that is timely and convenient, affordable and financially sustainable to fulfill quality assured pharmaceutical needs.The prerequisites to transformation from a brick-and-mortar pharmacy model to a progressive pharmacy is guided by the perspectives of investing in (1) human capital to retain and attract the best, (2) place to build a future-ready facility, (3) process to create greater value for patients by producing safe and quality products. The authors share their experience along these perspectives: a focus on staff development, training and well-being; a facility leveraging on automation, good manufacturing practice, and business continuity planning; processes to support medication use and new models of care.Technological disrupters such as the internet, social media, and AI are also changing the fabric of society. While future events may not take same form, they will require a deliberate effort from organization to navigate effectively and with agility. This chapter will also address the key considerations for a sustainable pharmacy in terms of self, environment and financial sustainability.