Global Research Trends in Stem Cells for Tendon from 1991 to 2020: A Bibliometric and Visualized Study

Background: Tendinopathy is a disabling musculoskeletal disorder affecting the athletic and general populations. There have been increased studies using stem cells in treating tendon diseases. The aim of this bibliometric and visualized study is to comprehensively investigate the current status and global trends of research in stem cells for tendon. Methods: Publications related to stem cells for tendon from 1991 to 2020 were retrieved from Web of Science. The source data were studied and indexed using a bibliometric methodology. VOS viewer software was used to conduct for the visualized study, including bibliographic coupling, co-authorship, co-citation and co-occurrence analysis and to analyze the publication trends of research in stem cells for tendon. Results: In total, 2492 articles were included. Though the relative research interests decline since 2018, the number of publications increased annually worldwide. The United States made the largest contribution to this field, with the most publications, citations and the highest H-index. The most contributive institutions were University of Pittsburgh, Zhejiang University, Shanghai Jiao Tong University and Chinese University of Hong Kong. The Journal of Orthopaedic Research published the most relative articles. Studies could be classified into five clusters: “animal study”, “tissue engineering”, “clinical study”, “mechanism research” and “stem cells research”, which show a trend of balanced development in this field. Conclusions: The number of publications on stem cells in treating tendon diseases may have reached a platform based on current global trends. The United States made the largest contribution to this field. In addition, according to the inherent changes of hotspots in each cluster and the possibilities of cross-research, the research in stem cells for tendon may exist a balanced development trend.

Emerging trends and focus of human gastrointestinal microbiome research from 2010–2021: a visualized study

Background The gastrointestinal microbiome is an important component of the human body and is closely related to human health and disease. This study describes the hotspots of the human gastrointestinal microbiome research and its evolution in the past decade, evaluates the scientific cooperation network, and finally predicts the field’s future development trend using bibliometric analysis and a visualized study. Methods We searched the original articles from January 2010 to February 2021 in the Scopus database using the term “gastrointestinal microbiome” and its synonyms. CiteSpace was used to construct country and author co-occurrence map; conduct journal, citation cocitation analysis, and reference co-citation knowledge map; and form a keywords co-occurrence map, a clustering knowledge map, timeline view of keywords, and burst term map. Result A total of 4444 documents published from January 2010 to February 2021 were analysed. In approximately the past decade, the number of articles on the human gastrointestinal microbiome has increased rapidly, and the research topics focus on different populations, research methods, and detection methods. All countries and regions in the world, led by the US, are studying the human gastrointestinal microbiome, and many research teams with close cooperation have been formed. The research has been published extensively in microbiology journals and clinical medicine journals, and the highly cited articles mainly describe the relationship between gastrointestinal microorganisms and human health and disease. Regarding the research emphasis, researchers' exploration of the human gastrointestinal microbiome (2011–2013) was at a relatively macro and superficial stage and sought to determine how the gastrointestinal microbiome relates to humans. From 2014 to 2017, increasingly more studies were conducted to determine the interaction between human gastrointestinal flora and various organs and systems. In addition, researchers (2018–2021) focused on the gastrointestinal microbial community and the diversity of certain types of microbes. Conclusion Over time, the scope of the research on the clinical uses of the gastrointestinal microbiome gradually increased, and the contents were gradually deepened and developed towards a more precise level. The study of the human gastrointestinal microbiome is an ongoing research hotspot and contributes to human health.

AB0870-HPR GLOBAL TRENDS IN PRP AND OSTEOARTHRITIS: A BIBLIOMETRIC AND VISUALIZED STUDY

Background:Osteoarthritis (OA) is a serious disease, which is one of the main causes of joint pain and body dysfunction, raising serious economic and social burden. In recent years, there are tremendous articles on the treatment of osteoarthritis, platelet rich plasma (PRP) is one of the new trends in the treatment of osteoarthritis.Objectives:The purpose of this study is to explore the development trend of PRP related osteoarthritis study and grasp the hot spots and directions in this field.Methods:Publications focusing on PRP related osteoarthritis research from 2001 to 2020 were retrieved from Web of Science (WoS) and Science Citation Index-Expanded (SCIE) database. The retrieving methods were as follow: (theme = platelet rich plasma arthritis OR theme = platelet rich plasma osteoarthritis OR theme = platelet rich plasma cartilage OR theme = platelet rich plasma knee OR theme = platelet rich plasma orthopedic OR theme = platelet rich plasma orthopaedic OR theme = platelet rich plasma articular OR theme = platelet rich plasma joint OR theme = platelet rich plasma tendon). Publications were analyzed only when type is articles or reviews. The VOS viewer was used for the generation of bibliographic coupling and visualized study.Results:A total of 2847 publications were retrieved, including 2636 articles and reviews. Before 2000, there were only 15 relevant papers, which were not included in the specific analysis. It is clear that the number of publications on PRP related OA study is increasing every year, a total of 398 articles or reviews were published in 2020. The United States is the leading country in this field, with a number of 932 publications (35.4%), followed by Italy (304 publications, 11.5%) and China (294 publications, 11.2%). The most prevalent areas of PRP related OA research were orthopedics (1013 papers, 38.4%), sports science (651 papers, 24.7%) and surgery (475 papers,18.0%). The top 3 journal that published the most PRP related OA study is American Journal of Sports Medicine (153 papers, 5.8%), Arthroscopy: The Journal of Arthroscopic & Related Surgery (95 papers, 3.6%), Journal of Orthopaedic Research (83 papers, 3.1%). The Harvard University (96 papers, 3.6%), Hospital for Special Surgery (83 papers, 3.1%) and University of London (75 papers, 2.8%) is the top 3 institution that published the most articles or reviews. Filardo G from Italy published the most articles or reviews (52, 2.0%) in this area, followed by Maffulli N from the UK (49 publications, 1.9%) and Kon E from Italy (46, 1.7%). PRP related OA study can be divided into five categories: intra-articular treatment study, clinical trials related study, soft tissue repairment study, gene and molecular biology study, regeneration and implantation study.Conclusion:Publications on PRP related OA study is increasing according to the analysis on current global trends. The United States is now the leading country in this field, with the largest number and the highest quality of publications. Among the five cluster of PRP related OA studies, “intra-articular treatment study” and “regeneration and implantation study” are considered to be the current research hotspots in the PRP related OA field.References:[1]Foster T E, Puskas B L, Mandelbaum B R, et al. Platelet-rich plasma: from basic science to clinical applications.[J]. American Journal of Sports Medicine, 2009, 37(11):2259-2272.Disclosure of Interests:None declared