Isolated left ventricular apical hypoplasia in a young child

A 16-month-old, healthy, asymptomatic male child presented with a diagnosis of dilated cardiomyopathy. Cardiovascular examination and chest radiograph were normal. ECG revealed sinus rhythm, and the augmented vector left lead showed raised ST segment, T wave inversion and q waves. Echocardiography showed a globular left ventricle with notched cardiac apex, abnormal echogenicity in the left ventricular apical myocardium, single papillary muscle and normal biventricular function. Cardiac MRI scan revealed a globular left ventricle with fibrofatty changes and retraction of the apex, the papillary muscles closely approximated, and the right ventricle wrapping around the apex of the left ventricle. This is described as isolated left ventricular apical hypoplasia. Diagnosis of this rare entity can be made by MRI, and it has been diagnosed largely in adults. The pathophysiology and long-term outcomes are unknown. We characterise the echocardiography findings of this rare anomaly in a child for the first time in the literature.

Postoperative Lead Movement after Deep Brain Stimulation Surgery and the Change of Stimulation Volume

Introduction: Lead movement after deep brain stimulation may occur and influence the affected volume of stimulation. The aim of the study was to investigate differences in lead position between the day after surgery and approximately 1 month postoperatively and also simulate the electric field (EF) around the active contacts in order to investigate the impact of displacement on affected volume. Methods: Twenty-three patients with movement disorders underwent deep brain stimulation surgery (37 leads). Computed tomography at the 2 time points were co-fused respectively with the stereotactic images in Surgiplan. The coordinates (x, y, and z) of the lead tips were compared between the 2 dates. Eleven of these patients were selected for the EF simulation in Comsol Multiphysics. Postoperative changes of EF spread in the tissue due to conductivity changes in perielectrode space and due to displacement were evaluated by calculating the coverage coefficient and the Sørensen-Dice coefficient. Results: There was a significant displacement (mean ± SD) on the left lead: x (0.44 ± 0.72, p < 0.01), y (0.64 ± 0.54, p < 0.001), and z (0.62 ± 0.71, p < 0.001). On the right lead, corresponding values were: x (−0.11 ± 0.61, ns), y (0.71 ± 0.54, p < 0.001), and z (0.49 ± 0.81, p < 0.05). The anchoring technique was a statistically significant variable associated with displacement. No correlation was found between bilateral (n = 14) versus unilateral deep brain stimulation, gender (n = 17 male), age <60 years (n = 8), and calculated air volume. The simulated stimulation volume was reduced after 1 month because of the perielectrode space. When considering perielectrode space and displacement, the volumes calculated the day after surgery and approximately 1 month later were partly overlapped. Conclusion: The left lead tip displayed a tendency to move lateral, anterior, and inferior and the right a tendency to move anterior and inferior. The anchoring technique was associated to displacement. New brain territory was affected due to the displacement despite considering the reduced stimulated volume after 1 month. Postoperative changes in perielectrode space and small lead movements are reasons for delaying programming to 4 weeks following surgery.

SEGMENT CRACKS AND ALIGNMENT ISSUES FOR TUNNELING CONSTRUCTION

This study describes the causes of shield tunnel segment cracks and alignment issues during shield tunnelling. The study was conducted in Down Town Line 3 (DTL3) contracts 926 and 927 twin tunnel projects in Singapore. It is revealed that these issues arose when Tunnel Boring Machine (TBM) shoving on curve alignment though TBM is designed with articulation, which allows the machines to handle tight curves with ease. The study focused on how construction methodology affects the quality of tunnelling in terms of alignment and segment cracks. It was found that the clearance between the tail shield and tunnel lining was not maintained during mining. As a result, the tail shield exerts stress on the segments and causes cracks. In addition, the tunnel alignment deviated from pre-designed alignment, which directly affects the safety and durability of the shield tunnel. This study concludes that a proper selection of ring type “right lead” or “left lead” and the appropriate key selection, along with the skill of the workers, significantly solve segment cracks and alignment issues.

CHARGE TRANSPORT THROUGH THIOPHENE BITHIOL MOLECULE AS A MOLECULAR WIRE

The conductance properties of the thiophene bithiol molecular wire, a nano-wire connecting two metallic electrodes, were investigated using quantum-mechanical based methods such as Density Functional Theory, in conjunction with non-equilibrium Green's function formalism. Using the quantum mechanics methods, the Hamiltonians of the three main parts of system, i.e. the right lead, the device, the left lead and conductance properties of this molecular wire such as I-V curve, were calculated.

The Gait Patterns of Olympic Dressage Horses

Limb contact variables of the gaits of dressage horses were determined for competitors at the 1988 Seoul Summer Olympic Games in the team and individual dressage competitions. Two 16-mm motion picture cameras filming at 100 fps were aimed perpendicular to the plane of equestrian motion along the HXF and MXK diagonals of the standard dressage arena. Eighteen competitors in team dressage were filmed during the Grand Prix test while executing the extended walk, extended trot, and left lead extended canter. Fifteen horses selected as finalists for individual dressage medals were filmed during the Grand Prix Special test executing the extended trot, one-stride canter lead changes, two-stride canter lead changes, and the left lead extended canter. Velocities of the extended walk, extended trot, and extended canter were positively related to stride length. Velocities of the Grand Prix extended walk and Grand Prix Special extended trot were positively related to stride frequency. Limb contact patterns of the extended walk stride appeared to have relatively little importance in scoring. Certain characteristics of the extended trot and extended canter were strongly related to scores attained in Grand Prix Special dressage tests, with highest scores achieved by horses with the longest, fastest strides. For canter strides involving lead changes, no limb contact variables were detected that were significantly related to scores. This study provided the first objective documentation of the limb contact patterns of the walk, trot, and canter of world-class dressage horses.