Synthetic Approaches and Biological Significance of Oxazolone Moieties: A Review

Oxazolone is a five-membered heterocyclic compound which is also known as azlactone. It contains one oxygen and one nitrogen as heteroatoms, which exist in five isomeric forms, according to the carbonyl group's location and the double bonds such as: 5 (4)-oxazolones, 5 (2) – oxazolones, 2 (3)-oxazolones, 4 (5)-oxazolones, and 2 (5)-oxazolones. 5 (4)-oxazolones is the most important heterocyclic moiety among all isomeric form of oxazolones. It is classified into two classes: saturated and unsaturated oxazolones. It is synthesized by various synthetic routes. Oxazolones are reported to exhibit various pharmacological activities such as antimicrobial, anti-inflammatory, anticancer, anti-HIV, antiangiogenic, anticonvulsant, sedative, cardiotonic, antidiabetic activity, etc.

A Scrupulous Review on Multifaceted Pyrazole Nucleus as an Energetic Pharmacological Agent

Pyrazole represents a versatile class among heterocyclic compounds due to its impact in biological and pharmacological field irrespective of its scarcity in nature. From the structural point of view, pyrazoles are rather interesting and chemically it is known as 1,2-Diazoles.Also, it is a five membered heterocyclic compound containing 2 Nitrogen atoms. As per different studies, Pyrazoles and its derivatives own a wide range of biological activities like Antibacterial, Analgesic, Antioxidant etc. The main intention of this review is to run an overview of diverse pharmacological activities of pyrazole moiety especially antimicrobial, anti-inflammatory, antioxidant, analgesic, Hypoglycemic, anticancer and enzyme inhibitory effects.

Multifunctional Hydantions: Recent Advances in Optoelectronics and in Medicinal drugs from Academia to Chemical Industry

Imidazilidine-2,4-dione, also well familiar as Hydantoin (TH) is one of the prominent five-membered heterocyclic compound with four versatile points of functionalities in its framework. Ever since the discovery of TH,...

Dearomative cycloadditions of a silylene with pyrazine and quinoxaline

The dearomative cycloaddition of a dialkylsilylene with pyrazine affords an eight-membered heterocyclic compound with a trans-cycloalkene moiety.

RECENT REPORTS ON PYRAZOLE-BASED BIOACTIVE COMPOUNDS AS CANDIDATE FOR ANTICANCER AGENTS

Pyrazole is a five-membered heterocyclic compound containing two nitrogen atoms. Due to its biological significance, design of novel pyrazole derivatives has become an interesting research area. We report the current progress in the development of anticancer agents containing pyrazole ring covering the time span of the past few years (2013–2016). The presence of this nucleus is accompanied with some side chains, functional groups, or in combination with other nucleus such as thiazole, thiourea, glucosamine, naphthalimide, and benzofuran. Several biologically active pyrazoles synthesized by numerous researchers across the world are summarized in this paper.

Selektive Additionsreaktionen an bifunktionalen neutralen Phosphenium-Ion-Komplexen / Selective Addition Reactions of Bifunctional Neutral Phosphenium Ion Complexes

The reaction of bifunctional neutral phosphenium ion complexes, containing a carbon-carbon triple bond next to a phosphorus-molybdenum multiple bond, with carbenes and to carbene isolobal organometallic fragments is discussed.So, the reaction of (R)(PhC=C)P=MoCp′(CO), (R = 2,4,6-′Bu3C6H2O; Cp′ = η5-C5H5: la; Cp′ = η5-C5Me5: 1b) with CH2,Ν2 (2) yields the three membered heterocyclic compound (3). 3 reacts with Co2(CO)8 to afford complex (5) in which the phenylethynyl building block is η2-side-on coordinated to a Co2(CO)6 fragment. Similar to the reaction of 1 with 2, 1 forms with Fe2(CO)9 (6), compound (7). In 7 the PMo double bond is coordinated in a η2 fashion to the 16-electron organometallic fragment Fe(CO)4. Using an excess of 6 and a higher temperature, the phosphorus-alkynyl-carbon σ-bond is cleaved, and cluster MoCp*Fe3(CO)8η3-PR)(C≡CPh) (8) is formed.The reaction of 1 with Cr(CO)5(THF) yields 10, a complex, in which the PhC≡C ligand is η2-coordinated to Cp′(CO)2Mo, and the Cr(CO)5 group forms a dative bond with the phosphorus atom.All new compounds have been characterized by analytical as well as by spectroscopic data (IR, 1H, 31P, 13C NMR, MS), compound 10 by an X-ray analysis.

Reactions of 1-Phenyl-1,2,3-triazolyllithium Compounds; Formation of Ketenimines, Alkynylamines, and Heterocycles from the Ambident (N-Phenyl)phenylketenimine Anion

At room temperature 1,4-diphenyl-1,2,3-triazolyllithium rapidly undergoes fragmentation to nitrogen and lithium (N-phenyl)phenylketenimine anion 8c, [Formula: see text]. Some of the reactions of this ambident anion have been studied. Reaction of 8c with methyl iodide results in C-methylation to a mixture of (N-phenyl)methylphenylketenimine and 3-methyl-1,3-diphenyl-4-(2′-phenylethylene)-2-phenyliminoazetidine. A six-membered heterocyclic compound, 6-anilino-1,3,5-triphenyluracil, results from the reaction between 8c and phenyl isocyanate. With dimethyl sulfate and methyl chloroformate N-alkylation and N-acylation takes place predominantly, forming N-methyl-N-phenyl-2-phenylethynylamine and N-carbomethoxy-N-phenyl-2-phenylethynylamine respectively. Reaction of 8c with methanol and ethanethiol gives an iminoester and an iminothioester respectively.1-Phenyl-1,2,3-triazolyllithium and 4-methyl-1-phenyl-1,2,3-triazolyllithium undergo fragmentation at somewhat higher temperatures.