Reactions of 1-Phenyl-1,2,3-triazolyllithium Compounds; Formation of Ketenimines, Alkynylamines, and Heterocycles from the Ambident (N-Phenyl)phenylketenimine Anion
At room temperature 1,4-diphenyl-1,2,3-triazolyllithium rapidly undergoes fragmentation to nitrogen and lithium (N-phenyl)phenylketenimine anion 8c, [Formula: see text]. Some of the reactions of this ambident anion have been studied. Reaction of 8c with methyl iodide results in C-methylation to a mixture of (N-phenyl)methylphenylketenimine and 3-methyl-1,3-diphenyl-4-(2′-phenylethylene)-2-phenyliminoazetidine. A six-membered heterocyclic compound, 6-anilino-1,3,5-triphenyluracil, results from the reaction between 8c and phenyl isocyanate. With dimethyl sulfate and methyl chloroformate N-alkylation and N-acylation takes place predominantly, forming N-methyl-N-phenyl-2-phenylethynylamine and N-carbomethoxy-N-phenyl-2-phenylethynylamine respectively. Reaction of 8c with methanol and ethanethiol gives an iminoester and an iminothioester respectively.1-Phenyl-1,2,3-triazolyllithium and 4-methyl-1-phenyl-1,2,3-triazolyllithium undergo fragmentation at somewhat higher temperatures.