Response triggering by an acoustic stimulus increases with stimulus intensity and is best predicted by startle reflex activation

In a simple reaction time task, the presentation of a startling acoustic stimulus has been shown to trigger the prepared response at short latency, known as the StartReact effect. However, it is unclear under what conditions it can be assumed that the loud stimulus results in response triggering. The purpose of the present study was to examine how auditory stimulus intensity and preparation level affect the probability of involuntary response triggering and the incidence of activation in the startle reflex indicator of sternocleidomastoid (SCM). In two reaction time experiments, participants were presented with an irrelevant auditory stimulus of varying intensities at various time points prior to the visual go-signal. Responses were independently categorized as responding to either the auditory or visual stimulus and those with or without SCM activation (i.e., SCM+/−). Both the incidence of response triggering and proportion of SCM+ trials increased with stimulus intensity and presentation closer to the go-signal. Data also showed that participants reacted to the auditory stimulus at a much higher rate on trials where the auditory stimulus elicited SCM activity versus those that did not, and a logistic regression analysis confirmed that SCM activation is a reliable predictor of response triggering for all conditions.

Oxytetracycline Degradation by Heat-Activated Peroxydisulfate and Peroxymonosulfate Oxidation: Optimization by Box-Behnken Design

This study investigates the removal of oxytetracycline performed by persulfate (PS) and peroxymonosulfate (PMS) processes. For this purpose, response surface methodology was used to examine the effectiveness of PS and PMS processes under both alkaline and thermal conditions. The effect of four independent variables, which were selected as pH, PS/PMS concentration, temperature, and time, were analyzed in a wide range. The working pH was between pH 3–11 to compare acidic and alkaline conditions, and the temperature was selected between 30 and 90°C to evaluate the effect of thermal activation of sulfate radicals for both processes. According to the results of prepared Response Surface Methodology (RSM) models, all four independent variables were determined to be highly significant for both PS and PMS. Especially in the PMS process, the highest PMS concentration was observed to complete degradation of OTC. The conditions for the highest removal were pH 9 and PS/PMS concentration was approximately 4mM for both processes, while the temperature and required time were 72.9°C and 75°C, 26.5 min and 20 min, for PS and PMS processes, respectively. PS process has higher kinetic constants at all pH values than the PMS process.

Dimensionless Assessment Method of Landslide Dam Formation Caused by Tributary Debris Flow Events

In this study, we develop a dimensionless assessment method to evaluate landslide dam formation by considering the relationship between the run-out distance of a tributary debris flow and the width of the main stream, deposition thickness of the tributary debris flow, and the water depth of the main stream. Based on the theory of debris flow run-out distance and fan formation, landslide dam formation may result from a tributary debris flow as a result of two concurrent formation processes: (1) the run-out distance of the tributary debris flow must be greater than the width of the main stream, and (2) the minimum deposition thickness of the tributary debris flow must be higher than the in situ water depth of the main stream. At the confluence, one of four types of depositional scenarios may result: (1) the tributary debris flow enters into the main stream and forms a landslide dam; (2) the tributary debris flow enters into the main stream but overflow occurs, thus preventing complete blockage of the main stream; (3) the tributary debris flow enters into the main stream, does not reach the far bank, and sediment remains partially above the water elevation of the main stream; or (4) the tributary debris flow enters into the main stream, does not reach the far bank, and sediment is fully submerged in the main stream. This method was applied to the analysis of 11 tributary debris flow events during Typhoon Morakot, and the results indicate that the dimensionless assessment method can be used to estimate potential areas of landslide dam formation caused by tributary debris flows. Based on this method, government authorities can determine potential areas of landslide dam formation caused by debris flows and mitigate possible disasters accordingly through a properly prepared response plan, especially for early identification.

Meeting the Challenges of International Crises: The Experience of the Iranian Blood Transfusion Organization

ABSTRACTCrises require a timely and well-prepared response by health services, especially those that are directly engaged with the lives of the patients such as blood services. The Iranian Blood Transfusion Organization as a single national authority of blood transfusion has left many crises behind. In this study, we examined the main international crises that the blood transfusion organization has faced during its 44-year history and objectively evaluated the methods for crisis risk reduction, both administrative and operational, all of which have led to fundamental advances in the organization. By proper planning and effective strategy setting, the Iranian Blood Transfusion Organization has managed to cope with international threats and in some cases has turned threats into opportunities to implement new, permanent administrative and operational strategies. It is not prudent for blood transfusion centers to develop their disaster risk reduction strategies on an individual-country basis in a world where global risk and crisis factors are rapidly increasing. Reduction of risk for blood transfusion centers must become a strategic priority nationally and globally. (Disaster Med Public Health Preparedness. 2019;13:410-413)

All New England Men and of the Best Material

Union Maj. Gen. Benjamin Franklin Butler’s move out of New Orleans into the bayou country of south Louisiana to gain control of important cotton and sugar production, and the Confederacy’s ill-prepared response.

Uncoupling response inhibition

The ability to prevent unwanted movement is fundamental to human behavior. When healthy adults must prevent a subset of prepared actions, execution of the remaining response is markedly delayed. We hypothesized that the delay may be sensitive to the degree of similarity between the prevented and continued actions. Fifteen healthy participants performed an anticipatory response inhibition task that required bilateral index finger extension or thumb abduction with homogeneous digit pairings, or a heterogeneous pairing of a combination of the two movements. We expected that the uncoupling of responses required for selective movement prevention would be more difficult with homogeneous (same digit, homologous muscles) than heterogeneous pairings (different digits, nonhomologous muscles). Measures of response times (and asynchrony between digits) during action execution, stopping performance, and electromyography from EIP (index finger extension) and APB (thumb abduction) were analyzed. As expected, selective trials produced a delay in the remaining movement compared with execution trials. Successful performance in the selective condition occurred via suppression of the entire prepared response and subsequent selective reinitiation of the remaining component. Importantly, the delayed reinitiation of motor output was sensitive to the degree of similarity between responses, occurring later but at a faster rate with homogeneous digits. There were persistent aftereffects from the selective condition on the motor system, which indicated greater levels of inhibition and a higher gain were necessary to successfully perform selective trials with homogeneous pairings. Overall, the results support a model of inhibition of a unitary response and selective reinitiation, rather than selective inhibition.

Electrophysiological Evidence for Different Inhibitory Mechanisms When Stopping or Changing a Planned Response

People are able to adapt their behavior to changing environmental contingencies by rapidly inhibiting or modifying their actions. Response inhibition is often studied in the stop-signal paradigm that requires the suppression of an already prepared motor response. Less is known about situations calling for a change of motor plans such that the prepared response has to be withheld but another has to be executed instead. In the present study, we investigated whether electrophysiological data can provide evidence for distinct inhibitory mechanisms when stopping or changing a response. Participants were instructed to perform in a choice RT task with two classes of embedded critical trials: Stop signals called for the inhibition of any response, whereas change signals required participants to inhibit the prepared response and execute another one instead. Under both conditions, we observed differences in go-stimulus processing, suggesting a faster response preparation in failed compared with successful inhibitions. In contrast to stop-signal trials, changing a response did not elicit the inhibition-related frontal N2 and did not modulate the parietal mu power decrease. The results suggest that compared with changing a response, additional frontal and parietal regions are engaged when having to inhibit a response.

“The Anonymous Christian and Christology”: A Response

In our last issue (January) we published three papers delivered at the Annual Meeting of the American Society of Missiology, including “The Anonymous Christian and Christology” by Fr. Robert Schreiter. We had originally intended to publish this prepared response in the same issue, but space limitations and schedules frustrated our efforts. Readers unable to attend the meeting will find interesting these sincere words of appreciation and critical evaluation — along with comments on alternatives. Dr. Danker suggests that a law/promise paradigm is more useful (and biblical) than knowledge/praxis in dealing with the nature/grace dichotomy.