Detailed analysis of chemical corrosion of ultra-thin wires used in drift chamber detectors

Ultra-thin metallic anode and cathode wires are frequently employed in low-mass gaseous detectors for precision experiments, where the amount of material crossed by charged particles must be minimised. We present here the results of an analysis of the mechanical stress and chemical corrosion effects observed in 40 and 50 μm diameter silver plated aluminum wires mounted within the volume of the MEG II drift chamber, which caused the breakage of about one hundred wires (over a total of ≈ 12000). This analysis is based on the careful inspection of the broken wires by means of optical and electronic microscopes and on a detailed recording of all breaking incidents. We present a simple empirical model which relates the number of broken wires to their exposure time to atmospheric relative humidity and to their mechanical tension, which is necessary for mechanical stability in the presence of electrostatic fields of several kV/cm. Finally we discuss how wire breakages can be avoided or at least strongly reduced by operating in controlled atmosphere during the mounting stages of the wires within the drift chamber and by choosing a 25 % thicker wire diameter, which has very small effects on the detector resolution and efficiency and can be obtained by using a safer fabrication technique.

Statistical Exploration of SENTINEL-1 Data, Terrain Parameters, and in-situ Data for Estimating the Near-Surface Soil Moisture in a Mediterranean Agroecosystem

Reliable near-surface soil moisture (θ) information is crucial for supporting risk assessment of future water usage, particularly considering the vulnerability of agroforestry systems of Mediterranean environments to climate change. We propose a simple empirical model by integrating dual-polarimetric Sentinel-1 (S1) Synthetic Aperture Radar (SAR) C-band single-look complex data and topographic information together with in-situ measurements of θ into a random forest (RF) regression approach (10-fold cross-validation). Firstly, we compare two RF models' estimation performances using either 43 SAR parameters (θNovSAR) or the combination of 43 SAR and 10 terrain parameters (θNovSAR+Terrain). Secondly, we analyze the essential parameters in estimating and mapping θ for S1 overpasses twice a day (at 5 a.m. and 5 p.m.) in a high spatiotemporal (17 × 17 m; 6 days) resolution. The developed site-specific calibration-dependent model was tested for a short period in November 2018 in a field-scale agroforestry environment belonging to the “Alento” hydrological observatory in southern Italy. Our results show that the combined SAR + terrain model slightly outperforms the SAR-based model (θNovSAR+Terrain with 0.025 and 0.020 m3 m−3, and 89% compared to θNovSAR with 0.028 and 0.022 m3 m−3, and 86% in terms of RMSE, MAE, and R2). The higher explanatory power for θNovSAR+Terrain is assessed with time-variant SAR phase information-dependent elements of the C2 covariance and Kennaugh matrix (i.e., K1, K6, and K1S) and with local (e.g., altitude above channel network) and compound topographic attributes (e.g., wetness index). Our proposed methodological approach constitutes a simple empirical model aiming at estimating θ for rapid surveys with high accuracy. It emphasizes potentials for further improvement (e.g., higher spatiotemporal coverage of ground-truthing) by identifying differences of SAR measurements between S1 overpasses in the morning and afternoon.

Diffusion Coefficients of Methane in Methylbenzene and Heptane at Temperatures between 323 K and 398 K at Pressures up to 65 MPa

We reported experimental measurements of the diffusion coefficient of methane at effectively infinite dilution in methylbenzene and in heptane at temperatures ranging from (323 to 398) K and at pressures up to 65 MPa. The Taylor dispersion method was used and the overall combined standard relative uncertainty was 2.3%. The experimental diffusion coefficients were correlated with a simple empirical model as well as the Stokes–Einstein model with the effective hydrodynamic radius of methane depending linearly upon the solvent density. The new data address key gaps in the literature and may facilitate the development of an improved predictive model for the diffusion coefficients of dilute gaseous solutes in hydrocarbon liquids.

A systematic approach to simultaneously evaluate safety, immunogenicity, and efficacy of novel tuberculosis vaccination strategies

Tuberculosis (TB) is the deadliest infectious disease worldwide. Bacille-Calmette-Guérin (BCG), the only licensed TB vaccine, affords variable protection against TB but remains the gold standard. BCG improvement is focused around three strategies: recombinant BCG strains, heterologous routes of administration, and booster vaccination. It is currently unknown whether combining these strategies is beneficial. The preclinical evaluation for new TB vaccines is heavily skewed toward immunogenicity and efficacy; however, safety and efficacy are the dominant considerations in human use. To facilitate stage gating of TB vaccines, we developed a simple empirical model to systematically rank vaccination strategies by integrating multiple measurements of safety, immunogenicity, and efficacy. We assessed 24 vaccination regimens, composed of three BCG strains and eight combinations of delivery. The model presented here highlights that mucosal booster vaccination may cause adverse outcomes and provides a much needed strategy to evaluate and rank data obtained from TB vaccine studies using different routes, strains, or animal models.