Therapeutic Application of Genetically Engineered Ribosome-Inactivating Toxin Proteins for Cancer

Recently, Ribosome-Inactivating Proteins (RIPs) as a class of anticancer medicines have garnered considerable attention due to their novel anticancer mechanism. Although the medications are small, RIPs utilize the Large-Size Effect (LSE) to block the efflux procedure that are regulated through Drug Resistance Transporters (DRTs), and protect host cells from drug transfection. There are many significant challenges for their therapeutic applications that seriously restrict their usefulness, particularly their strategy towards tumor cells. The primary objective of this review is to emphasize Trichosanthin (TCS) along with Gelonin (Gel) and additional types of RIPs, particularly scorpion venom-derived RIPs, to demonstrate that they should be grappling through what kinds of bio-barriers to overcome in cancer therapeutic science. Next, we will emphasize the latest state-of-the-art in providing cancer treatment RIPs.

Beach volleyball spike arm swing techniques of Olympics and world championships winners (1996–2019) reveal gender differences

The spike attack is one of the most important skills in beach volleyball, and as an overarm movement, places significant load on the shoulder joint that could lead to increased risk of injury. An analysis of the different techniques used by elite athletes could provide important insights regarding the etiology of these injuries. This study aimed to assess the spike attack arm swing techniques of Olympics and World Championships (1996-2019) beach volleyball winners and to investigate possible gender differences. Twenty-five male and twenty female winners were assessed on video recordings from eighteen competitions. The different arm swing techniques in the cocking phase (Straight, Bow-and-arrow high, Bow-and-arrow low, Snap, and Circular) were classified by two experts. Intra-rater reliability of both experts (κ = 1.000, P < .001 and κ = .969, P < .001 respectively) and inter-rater reliability (κ = .969, P < .001), assessed by Cohen’s Kappa, were almost perfect. There were significant gender differences in arm swing techniques ( P < .001) with a large size effect (Cramer’s V = .650). The most frequent technique for men was the Bow-and-arrow low (56%) followed by Circular (24%) and Bow-and-arrow high (20%), while for women were the Bow-and-arrow high (30%) and Snap (30%), followed by Bow-and-arrow low (25%) and Straight (15%). The results showed a great variation in arm swing techniques even among world class beach volleyball players as well as significant gender differences, and could allow us to develop interesting hypotheses regarding the mechanisms that could lead to shoulder overuse injuries.

Effectiveness of Ultrasound-Guided Percutaneous Electrolysis for Musculoskeletal Pain: A Systematic Review and Meta-Analysis

Objective To evaluate the effects of ultrasound-guided percutaneous electrolysis alone or as an adjunct to other interventions on pain and pain-related disability for musculoskeletal pain conditions. Databases and Data Treatment Search of MEDLINE database, Allied and Complementary Medicine Database, EMBASE database, Cumulative Index to Nursing & Allied Health Literature database, EBSCO database, PubMed database, Physiotherapy Evidence Database, Cochrane Library database, Scopus database, and Web of Science database. Randomized controlled trials in which at least one group received ultrasound-guided percutaneous electrolysis for treatment of musculoskeletal pain. To be eligible, studies had to include humans and collect outcomes on pain intensity and pain-related disability for musculoskeletal pain syndromes. Data were extracted by two reviewers. The risk of bias was assessed by the Cochrane Guidelines and the quality of evidence was reported using the Grading of Recommendations Assessment, Development and Evaluation approach. Standardized mean differences (SMDs) and random effects were calculated. Results Ten studies were included. The meta-analysis found that ultrasound-guided percutaneous electrolysis reduced the mean pain intensity by –2.06 (95% confidence interval [CI], –2.69 to –1.42) and the pain intensity as assessed with a visual analog scale or a numeric pain rating scale with a large size effect (SMD = –1.15; 95% CI, –1.48 to –0.81) and also improved pain-related disability with a large size effect (SMD = 0.95; 95% CI, 0.73–1.18) as compared with comparison groups. No differences in effect sizes were found among the short-term, midterm, and long-term follow-ups. The risk of bias was generally low, but the heterogeneity of the overall result downgraded the evidence level. Trials included heterogeneous musculoskeletal pain conditions and short-term, midterm, and long-term follow-ups. Conclusion Moderate evidence suggests positive effects of ultrasound-guided percutaneous electrolysis for pain and pain-related disability in musculoskeletal pain conditions relative to a comparison group in the short term, midterm, and long term.

The comparison of postural balance in elderly active, sedentary and with vestibulopathy.

Introduction: To be sedentary and have any disease with regard to vestibular pathology can compromise the performance of the postural control and increases the risk of falls. Objective: This study aimed to compare the postural control of elderly active, sedentary and vestibular pathology. Methods: The sample consisted of 45 elderly separated according to their current health condition: elderly active, sedentary and with vestibulopathy. The postural balance tests were performed in bipedal support, eyes open and the variables measured by the force platform were the center of pressure and average speeds of postural sway in the directions, anteroposterior (A/P) and medial-lateral (M/L). Results: Elderly with vestibulopathy presented significantly poorer postural balance (P <0.05) that active and sedentary group, with large size effect: in mean d >0.80. Conclusion: Elderly with vestibulopathy have poor postural balance that elderly active and sedentary. These findings have any implications for programs of rehabilitation for vestibular disorders.

Different Relaxation Modes of Epitaxial Thin Film Alloys With A Large Size Effect

In epitaxial layers, the mechanism of stress relaxation under consideration is in general dislocations. This paper will present experimental evidences for other modes of relaxation. which may occur in some situations especially where a strong size effect or misfit is present. In fact the stress is the driving force for intermixing, twinning, and phase transformation, which are not expected to occur in the bulk. All these experimental results have been sustained by numerical simulations that will also be presented.