Slag concrete brick, as a kind of new materials utilizing wastes, is one kind of subsistent for clay brick. However, research on Slag concrete brick is very few, which restrains applying for slag concrete brick. By analyzing the reliability of the compress specimen with slag concrete brick masonry, the resistant statistic parameters are obtained and the computer probabilistic formula is established. Its reliability based on Monte-Carlo Method is calculated by means of Matlab. The result calculated is reasonable and reliable, which meets the requirement in rules. With the increasing of radio of live loading to dead loading, change tendency of reliability index of slag concrete masonry is that both sides are low and center is tall, and maximum appears between 0.5 and 1.0.