Post-burns itch, or pruritus, is one of the most common and distressing complications of burn injury. It typically begins in the first two weeks after the injury, and may last for several years. Post-burn pruritus can interfere with daily activities, and also complicate healing when scratched. This chapter outlines the causes, epidemiology, and biology of itching then provides an overview of therapies available. Assessment scales and the classification of types of pruritus are also outlined.