This chapter deals with the extensive poisoning of the environment to exterminate mhesvi. Given the massive amounts of organochlorine pesticides (OCPs) dumped into the environment to kill mhesvi, OCPs present an opportunity to explore the question of pollution and its health effects. The chapter introduces and accounts for the specific circumstances by which OCPs arrived in Southern Rhodesia. In fact, by the time organochlorines like DDT, BHC, and dieldrin and organophosphates like Thallium were deployed in combat against mhesvi, hutunga, hwiza (locusts), and zvimokoto (quelea birds) after World War II, Southern Rhodesia's farmers had been dispatching mhuka, shiri, zvipukanana, and hutachiwana with chepfu through ingestion, inhalation, and skin contact for over fifty years. The chapter therefore starts from this earlier history, well before DDT and its peers, in search of antecedents that profoundly shaped and offered a broader context for the use of OCPs.