This chapter deals with a plethora of metabolic and endocrine abnormalities from an anaesthetic perspective. Major biochemical cation derangements are covered including high and low sodium, potassium, calcium, and magnesium levels. Guidelines are also presented for the management of anaphylaxis/severe allergy, diabetic ketoacidosis, and hyperosmolar non-ketotic coma, malignant hyperthermia, porphyric crisis, thyrotoxic storm, phaeochromocytoma, Addisonian crisis, disseminated intravascular coagulopathy, hypoglycaemia, acute liver failure, sickle cell crisis, TURP syndrome, and hypothermia. In addition, the definitions, presentation, management strategies, investigations, risk factors, exclusions and causes, and any special considerations for each potential metabolic and endocrine-related situation are given and elaborated upon. Lists of up-to-date online resources and further reading are also provided here, offering invaluable know-how to encourage the reader to broaden their knowledge.