To adequately manage and prevent HIV disease, it is important to address lifestyle behaviors such as substance use and risky sexual behaviors, which are considered as sexual behaviors that increase the risk of negative outcomes, such as condomless sex, multiple partners, sex under the influence of drug and alcohol, IV drug use, paying for sex, and untreated sexually transmitted illness, among others. Motivational interviewing (MI) has been shown to be effective in helping patients in HIV care reduce substance use and risky sexual behaviors. Using MI skills and strategies helps facilitate discussions and minimize barriers that prevent patients from having open conversations with their practitioners about stigmatized or “unhealthy” behaviors. MI is not a comprehensive intervention, but it is a tool that combines strategies and spirit to produce conversations that can help patients resolve their ambivalence in the direction of change and can be used in combination with other practical interventions approaches when addressing other areas of health promotion.