Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity

A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

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Phytochemical investigation of Lampranthus glaucus and Lampranthus aurantiacus, family Aizoaceae and evaluation of their cytotoxic activity

Natural Product Research ◽

10.1080/14786419.2021.1940178 ◽

2021 ◽

pp. 1-4

Author(s):

Nagwan Mostafa Gabr ◽

Marwa Refaat Abdel-Khalek ◽

Haitham Hamdy Abdel-Gawad ◽

Suzan Adib Mina

Keyword(s):

Cytotoxic Activity ◽

Phytochemical Investigation

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Socotroside, a New Pentacyclic Cucurbitane Glycoside from Dendrosicyos socotrana

Zeitschrift für Naturforschung B ◽

10.1515/znb-2008-1212 ◽

2008 ◽

Vol 63 (12) ◽

pp. 1415-1420 ◽

Cited By ~ 4

Author(s):

Osama B. Abdel Halim ◽

El-Sayed M. Marawan ◽

Ali A. El-Gamal ◽

Mona G. Zaghloul

Keyword(s):

Ethyl Acetate ◽

Cytotoxic Activity ◽

Spectral Data ◽

Ethyl Acetate Extract ◽

Phytochemical Investigation

Phytochemical investigation of the ethyl acetate extract of the stem of Dendrosicyos socotrana Balf. f. resulted in the isolation of a new pentacyclic cucurbitane glycoside Socotroside, in addition to the three known cucurbitacins, dihydrocucurbitacin D, dihydrocucurbitacin F and cucurbitacin G. The structures of the isolated compounds were established on the basis of their spectral data. The isolated cucurbitacin aglycones showed marked cytotoxic activity.

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ChemInform Abstract: Phytochemical Investigation of Labdane Diterpenes from the Rhizomes of Hedychium spicatum and Their Cytotoxic Activity.

ChemInform ◽

10.1002/chin.201009184 ◽

2010 ◽

Vol 41 (9) ◽

Author(s):

P. Prabhakar Reddy ◽

R. Ranga Rao ◽

J. Shashidhar ◽

B. S. Sastry ◽

J. Madhusudana Rao ◽

...

Keyword(s):

Cytotoxic Activity ◽

Phytochemical Investigation

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Chemical Constituents of the Roots and Rhizomes of Saposhnikovia divaricata and their Cytotoxic Activity

Natural Product Communications ◽

10.1177/1934578x1701200229 ◽

2017 ◽

Vol 12 (2) ◽

pp. 1934578X1701200 ◽

Cited By ~ 2

Author(s):

Akihito Yokosuka ◽

Satoru Tatsuno ◽

Takuma Komine ◽

Yoshihiro Mimaki

Keyword(s):

Cytotoxic Activity ◽

Apoptotic Cell ◽

Chemical Constituents ◽

Leukemia Cells ◽

Caspase 9 ◽

Meoh Extract ◽

Apoptotic Pathway ◽

Phytochemical Investigation ◽

Saposhnikovia Divaricata ◽

First Time

Phytochemical investigation of the MeOH extract of the roots and rhizomes of Saposhnikovia divaricata (Umbelliferae) resulted in the isolation of six chromons (1-6) and five polyacetylene derivatives (7-11). Compounds 9 and 11 were isolated from S. divaricate for the first time. The chromon derivatives (1-6) were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 (3′- O-angeloylhamaudol) showed the most potent cytotoxic activity with an IC50 value of 4.41 μM and was found to induce apoptotic cell death in HL-60 cells. The loss of mitochondrial membrane potential, release of cytochrome c into the cytoplasm, and activation of caspase-9 in the 1-treated HL-60 cells suggests that 1 induces apoptosis through the mitochondrial-dependent apoptotic pathway.

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Canthin-6-one Alkaloids and a Tirucallanoid from Eurycoma longifolia and Their Cytotoxic Activity against a Human HT-1080 Fibrosarcoma Cell Line

Natural Product Communications ◽

10.1177/1934578x1000500105 ◽

2010 ◽

Vol 5 (1) ◽

pp. 1934578X1000500 ◽

Cited By ~ 1

Author(s):

Katsunori Miyake ◽

Yasuhiro Tezuka ◽

Suresh Awale ◽

Feng Li ◽

Shigetoshi Kadota

Keyword(s):

Cytotoxic Activity ◽

Natural Product ◽

Cell Line ◽

Positive Control ◽

Mass Spectrometric ◽

Fibrosarcoma Cell ◽

Eurycoma Longifolia ◽

Phytochemical Investigation ◽

Eurycoma Longifolia Jack ◽

First Time

Phytochemical investigation of the stems of Eurycoma longifolia Jack led to the isolation of two new canthin-6-one alkaloids, 4,9-dimethoxycanthin-6-one (1) and 10-hydroxy-11-methoxycanthin-6-one (2), and a new tirucallane-type triterpenoid, 23,24,25-trihydroxytirucall-7-en-3,6-dione (3), along with 37 known compounds. Among these, an oxasqualenoid (4) was isolated as a natural product for the first time. The structures of the isolates were elucidated by spectroscopic and mass spectrometric means. All the isolates were evaluated for their cytotoxic activity against a HT-1080 human fibrosarcoma cell line. Among them, 9,10-dimethoxycanthin-6-one (14, IC50 = 5.0 μM), 10-hydroxy-9-methoxycanthin-6-one (15, IC50 = 7.2 μM), dihydroniloticin (18, IC50 = 8.2 μM), and 14-deacetyleurylene (34, IC50 = 3.2 μM) displayed stronger activity than the positive control 5-FU (IC50 = 9.2 μM).

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The first phytochemical investigation of Rhododendron websterianum : triterpenoids and their cytotoxic activity

Phytochemistry Letters ◽

10.1016/j.phytol.2018.03.015 ◽

2018 ◽

Vol 25 ◽

pp. 43-46 ◽

Cited By ~ 1

Author(s):

Rui Zhang ◽

Chunping Tang ◽

Yan Li ◽

Chang-Qiang Ke ◽

Ge Lin ◽

...

Keyword(s):

Cytotoxic Activity ◽

Phytochemical Investigation

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Dialiumoside, an Olean-18-ene Triterpenoid from Dialium excelsum

Zeitschrift für Naturforschung B ◽

10.1515/znb-2011-0610 ◽

2011 ◽

Vol 66 (6) ◽

pp. 624-628 ◽

Cited By ~ 5

Author(s):

Angelbert F. Awantu ◽

Bruno N. Lenta ◽

Tobias Bogner ◽

Yanick F. Fongang ◽

Silvère Ngouela ◽

...

Keyword(s):

Biological Activity ◽

Cytotoxic Activity ◽

Stem Bark ◽

Spectroscopic Methods ◽

Cervix Carcinoma ◽

Drug Resistant ◽

Cytotoxicity Assays ◽

Phytochemical Investigation ◽

Reported Data ◽

Human Cervix

Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2 - 13). The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1 - 13 were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and the related multi drug-resistant P-gp-expressing KB-V1 cells. Compounds 1 and 13 showed weak biological activity in cytotoxicity assays while other compounds were inactive.

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A New Ellagic Acid From the Leaves and Twigs of Irvingia malayana

Natural Product Communications ◽

10.1177/1934578x19848164 ◽

2019 ◽

Vol 14 (5) ◽

pp. 1934578X1984816

Author(s):

Thaworn Jaipetch ◽

Sakchai Hongthong ◽

Samreang Bunteang ◽

Radeekorn Akkarawongsapat ◽

Jitra Limthongkul ◽

...

Keyword(s):

Cytotoxic Activity ◽

Ellagic Acid ◽

Inhibitory Activity ◽

Moderate Activity ◽

Spectroscopic Techniques ◽

Inhibition Assay ◽

Phytochemical Investigation ◽

Cancerous Cell ◽

Reverse Transcriptase Assay ◽

Hiv 1

A phytochemical investigation of the leaves and twigs of Irvingia malayana led to the isolation of a new 3,3′,4′-tri- O-methylellagic acid-6″-acetoxy-4- O-β-glucoside (1), along with 3,3′,4′-tri- O-methylellagic acid (2), 3,3′-di- O-methylellagic acid-4- O-β-xyloside (3), 3,3′,4′-tri- O-methylellagic acid-4-β -O-glucoside (4), friedelin (5), friedelinol (6), methyl-3,4,5-trihydroxybenzoate (7), 5,7,4′-trihydroxyflavone-8- C-β-glucopyranoside (8), 5,7,3′,4′-tetrahydroxyflavone-8- C-β-glucopyranoside (9), and 5,3′,4′-trihydroxyflavone-6- C-β-glucopyranoside (10). Their structures were elucidated by means of spectroscopic techniques and direct comparison with literature data. Compounds 4 and 7 showed weak cytotoxic activity against a panel of mammalian cancerous cell lines. Furthermore, compounds 1, 2, 4, and 9 exhibited significant inhibitory activity in the syncytium inhibition assay, whereas compounds 8 and 9 displayed moderate activity in the HIV 1 reverse transcriptase assay.

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