Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity

2022 ◽  
Author(s):  
Xiang-Wei Xu ◽  
Yi-Yuan Xi ◽  
Jun Chen ◽  
Feng Zhang ◽  
Ju-Jia Zheng ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Xanthium Strumarium ◽  
Phytochemical Investigation

Phytochemical Constituents of Annona reticulata and their Cytotoxic Activity

2020 ◽  
Vol 17 (3) ◽  
pp. 206-210
Author(s):  
Ty Viet Pham ◽  
Thang Quoc Le ◽  
Anh Tuan Le ◽  
Hung Quoc Vo ◽  
Duc Viet Ho
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Structural Determination ◽  
Phytochemical Investigation ◽  
Ic50 Values ◽  
Phytochemical Constituents ◽  
First Time ◽  
Annona Reticulata

A phytochemical investigation of the leaves of Annona reticulata led to the isolation and structural determination of β-sitosterol (1), ent-pimara-8(14),15-dien-19-oic acid (2), ent-pimara- 8(14),15-dien-19-ol (3), quercetin (4), quercetin 3-O-α-L-arabinopyranoside (5), and a mixture of quercetin 3-O-β-D-galactopyranoside (6a) and quercetin 3-O-β-D-glucopyranoside (6b). Of these, compounds 2 and 3 were isolated from the genus Annona for the first time. Compound 3 showed strong cytotoxicity against SK-LU-1 and SW626 cell lines with IC50 values of 17.64 ± 1.07 and 19.79 ± 1.41 μg mL-1, respectively.

Phytochemical investigation of Lampranthus glaucus and Lampranthus aurantiacus, family Aizoaceae and evaluation of their cytotoxic activity

2021 ◽  
pp. 1-4
Author(s):  
Nagwan Mostafa Gabr ◽  
Marwa Refaat Abdel-Khalek ◽  
Haitham Hamdy Abdel-Gawad ◽  
Suzan Adib Mina
Keyword(s):  
Cytotoxic Activity ◽  
Phytochemical Investigation

Socotroside, a New Pentacyclic Cucurbitane Glycoside from Dendrosicyos socotrana

2008 ◽  
Vol 63 (12) ◽  
pp. 1415-1420 ◽  
Author(s):  
Osama B. Abdel Halim ◽  
El-Sayed M. Marawan ◽  
Ali A. El-Gamal ◽  
Mona G. Zaghloul
Keyword(s):  
Ethyl Acetate ◽  
Cytotoxic Activity ◽  
Spectral Data ◽  
Ethyl Acetate Extract ◽  
Phytochemical Investigation

Phytochemical investigation of the ethyl acetate extract of the stem of Dendrosicyos socotrana Balf. f. resulted in the isolation of a new pentacyclic cucurbitane glycoside Socotroside, in addition to the three known cucurbitacins, dihydrocucurbitacin D, dihydrocucurbitacin F and cucurbitacin G. The structures of the isolated compounds were established on the basis of their spectral data. The isolated cucurbitacin aglycones showed marked cytotoxic activity.

ChemInform Abstract: Phytochemical Investigation of Labdane Diterpenes from the Rhizomes of Hedychium spicatum and Their Cytotoxic Activity.

ChemInform ◽  
2010 ◽  
Vol 41 (9) ◽  
Author(s):  
P. Prabhakar Reddy ◽  
R. Ranga Rao ◽  
J. Shashidhar ◽  
B. S. Sastry ◽  
J. Madhusudana Rao ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Phytochemical Investigation

scholarly journals Chemical Constituents of the Roots and Rhizomes of Saposhnikovia divaricata and their Cytotoxic Activity

2017 ◽  
Vol 12 (2) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Akihito Yokosuka ◽  
Satoru Tatsuno ◽  
Takuma Komine ◽  
Yoshihiro Mimaki
Keyword(s):  
Cytotoxic Activity ◽  
Apoptotic Cell ◽  
Chemical Constituents ◽  
Leukemia Cells ◽  
Caspase 9 ◽  
Meoh Extract ◽  
Apoptotic Pathway ◽  
Phytochemical Investigation ◽  
Saposhnikovia Divaricata ◽  
First Time

Phytochemical investigation of the MeOH extract of the roots and rhizomes of Saposhnikovia divaricata (Umbelliferae) resulted in the isolation of six chromons (1-6) and five polyacetylene derivatives (7-11). Compounds 9 and 11 were isolated from S. divaricate for the first time. The chromon derivatives (1-6) were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Compound 1 (3′- O-angeloylhamaudol) showed the most potent cytotoxic activity with an IC50 value of 4.41 μM and was found to induce apoptotic cell death in HL-60 cells. The loss of mitochondrial membrane potential, release of cytochrome c into the cytoplasm, and activation of caspase-9 in the 1-treated HL-60 cells suggests that 1 induces apoptosis through the mitochondrial-dependent apoptotic pathway.

scholarly journals Canthin-6-one Alkaloids and a Tirucallanoid from Eurycoma longifolia and Their Cytotoxic Activity against a Human HT-1080 Fibrosarcoma Cell Line

2010 ◽  
Vol 5 (1) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Katsunori Miyake ◽  
Yasuhiro Tezuka ◽  
Suresh Awale ◽  
Feng Li ◽  
Shigetoshi Kadota
Keyword(s):  
Cytotoxic Activity ◽  
Natural Product ◽  
Cell Line ◽  
Positive Control ◽  
Mass Spectrometric ◽  
Fibrosarcoma Cell ◽  
Eurycoma Longifolia ◽  
Phytochemical Investigation ◽  
Eurycoma Longifolia Jack ◽  
First Time

Phytochemical investigation of the stems of Eurycoma longifolia Jack led to the isolation of two new canthin-6-one alkaloids, 4,9-dimethoxycanthin-6-one (1) and 10-hydroxy-11-methoxycanthin-6-one (2), and a new tirucallane-type triterpenoid, 23,24,25-trihydroxytirucall-7-en-3,6-dione (3), along with 37 known compounds. Among these, an oxasqualenoid (4) was isolated as a natural product for the first time. The structures of the isolates were elucidated by spectroscopic and mass spectrometric means. All the isolates were evaluated for their cytotoxic activity against a HT-1080 human fibrosarcoma cell line. Among them, 9,10-dimethoxycanthin-6-one (14, IC50 = 5.0 μM), 10-hydroxy-9-methoxycanthin-6-one (15, IC50 = 7.2 μM), dihydroniloticin (18, IC50 = 8.2 μM), and 14-deacetyleurylene (34, IC50 = 3.2 μM) displayed stronger activity than the positive control 5-FU (IC50 = 9.2 μM).

The first phytochemical investigation of Rhododendron websterianum : triterpenoids and their cytotoxic activity

2018 ◽  
Vol 25 ◽  
pp. 43-46 ◽  
Author(s):  
Rui Zhang ◽  
Chunping Tang ◽  
Yan Li ◽  
Chang-Qiang Ke ◽  
Ge Lin ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Phytochemical Investigation

Dialiumoside, an Olean-18-ene Triterpenoid from Dialium excelsum

2011 ◽  
Vol 66 (6) ◽  
pp. 624-628 ◽  
Author(s):  
Angelbert F. Awantu ◽  
Bruno N. Lenta ◽  
Tobias Bogner ◽  
Yanick F. Fongang ◽  
Silvère Ngouela ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cytotoxic Activity ◽  
Stem Bark ◽  
Spectroscopic Methods ◽  
Cervix Carcinoma ◽  
Drug Resistant ◽  
Cytotoxicity Assays ◽  
Phytochemical Investigation ◽  
Reported Data ◽  
Human Cervix

Phytochemical investigation of the stem bark and fruits of Dialium excelsum led to the isolation of a new triterpenoid, named dialiumoside (1), together with twelve known compounds (2 - 13). The structure of the new compound as well as those of the known compounds were established by means of spectroscopic methods and by comparison with previously reported data. Compounds 1 - 13 were tested for their cytotoxic activity against the human cervix carcinoma KB-3-1 cells and the related multi drug-resistant P-gp-expressing KB-V1 cells. Compounds 1 and 13 showed weak biological activity in cytotoxicity assays while other compounds were inactive.

scholarly journals A New Ellagic Acid From the Leaves and Twigs of Irvingia malayana

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984816
Author(s):  
Thaworn Jaipetch ◽  
Sakchai Hongthong ◽  
Samreang Bunteang ◽  
Radeekorn Akkarawongsapat ◽  
Jitra Limthongkul ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Ellagic Acid ◽  
Inhibitory Activity ◽  
Moderate Activity ◽  
Spectroscopic Techniques ◽  
Inhibition Assay ◽  
Phytochemical Investigation ◽  
Cancerous Cell ◽  
Reverse Transcriptase Assay ◽  
Hiv 1

A phytochemical investigation of the leaves and twigs of Irvingia malayana led to the isolation of a new 3,3′,4′-tri- O-methylellagic acid-6″-acetoxy-4- O-β-glucoside (1), along with 3,3′,4′-tri- O-methylellagic acid (2), 3,3′-di- O-methylellagic acid-4- O-β-xyloside (3), 3,3′,4′-tri- O-methylellagic acid-4-β -O-glucoside (4), friedelin (5), friedelinol (6), methyl-3,4,5-trihydroxybenzoate (7), 5,7,4′-trihydroxyflavone-8- C-β-glucopyranoside (8), 5,7,3′,4′-tetrahydroxyflavone-8- C-β-glucopyranoside (9), and 5,3′,4′-trihydroxyflavone-6- C-β-glucopyranoside (10). Their structures were elucidated by means of spectroscopic techniques and direct comparison with literature data. Compounds 4 and 7 showed weak cytotoxic activity against a panel of mammalian cancerous cell lines. Furthermore, compounds 1, 2, 4, and 9 exhibited significant inhibitory activity in the syncytium inhibition assay, whereas compounds 8 and 9 displayed moderate activity in the HIV 1 reverse transcriptase assay.

Phytochemical investigation of sesquiterpenes from the fruits of Schisandra chinensis and their cytotoxic activity

Fitoterapia ◽  
2014 ◽  
Vol 95 ◽  
pp. 102-108 ◽  
Author(s):  
A. Venkanna ◽  
B. Siva ◽  
B. Poornima ◽  
P.R. Rao Vadaparthi ◽  
K. Rajendra Prasad ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Schisandra Chinensis ◽  
Phytochemical Investigation
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