scholarly journals Saponin constituents of Achyranthes root

2022 ◽  
Author(s):  
Fumiyuki Kiuchi
Keyword(s):  
Dicarboxylic Acid ◽  
Oleanolic Acid ◽  
Hplc Analysis ◽  
Biological Activities ◽  
Blood Stasis ◽  
Acid Moiety ◽  
Triterpene Saponin ◽  
Crude Drug ◽  
Achyranthes Root

AbstractAchyranthes root is a crude drug used as diuretic, tonic and remedy for blood stasis. Characteristic oleanolic acid saponins with a dicarboxylic acid moiety have been isolated as one of the representative constituents of this crude drug. This review focuses on the triterpene saponin constituents, especially those with a characteristic dicarboxylic acid moiety, of A. bidentata and A. fauriei. Several groups isolated the saponins and different names were given to one compound in some cases. The names of the compounds are sorted out and the stereochemistry of the dicarboxylic acid moieties are summarized. HPLC analysis of the composition of the saponin constituents and the effect of processing and extraction conditions on the composition are reviewed. Biological activities of the saponin constituents are also summarized.

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives

2014 ◽  
Vol 12 (28) ◽  
pp. 5192-5200 ◽  
Author(s):  
Liangfeng Fu ◽  
Qi-Xian Lin ◽  
Karen T. Liby ◽  
Michael B. Sporn ◽  
Gordon W. Gribble
Keyword(s):  
Methyl Ester ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Efficient Synthesis

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester).

scholarly journals Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

MedChemComm ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 1370-1378 ◽  
Author(s):  
Chun-Mei Liu ◽  
Jia-Yan Huang ◽  
Li-Xin Sheng ◽  
Xiao-An Wen ◽  
Ke-Guang Cheng
Keyword(s):  
Antitumor Activity ◽  
Adverse Effects ◽  
Ursolic Acid ◽  
Oleanolic Acid ◽  
Biological Activities ◽  
Glycyrrhetinic Acid ◽  
Antitumor Activities ◽  
Pentacyclic Triterpene ◽  
Pentacyclic Triterpenes

Due to the obvious adverse effects of 5-fluorouracil and considering the diverse biological activities of pentacyclic triterpenes, twelve pentacyclic triterpene-5-fluorouracil conjugates were synthesized and their antitumor activities were evaluated.

ChemInform Abstract: Oleanolic Acid Synthetic Oligoglycosides: A Review on Recent Progress in Biological Activities

ChemInform ◽  
2014 ◽  
Vol 45 (39) ◽  
pp. no-no ◽  
Author(s):  
Kuo Xu ◽  
Fuhao Chu ◽  
Guoliang Li ◽  
Xin Xu ◽  
Penglong Wang ◽  
...  
Keyword(s):  
Oleanolic Acid ◽  
Recent Progress ◽  
Biological Activities

Determination of some surface-active characteristics of solutions of triterpene saponin derivatives of oleanolic acid

2010 ◽  
Vol 44 (3) ◽  
pp. 157-160 ◽  
Author(s):  
N. V. Mironenko ◽  
T. A. Brezhneva ◽  
T. N. Poyarkova ◽  
V. F. Selemenev
Keyword(s):  
Oleanolic Acid ◽  
Triterpene Saponin ◽  
Surface Active ◽  
Derivatives Of

Hypotensive effects of the triterpene oleanolic acid for cardiovascular prevention

2020 ◽  
Vol 13 ◽  
Author(s):  
A. Sureda ◽  
M. Monserrat-Mesquida ◽  
S. Pinya ◽  
P. Ferriol ◽  
S. Tejada
Keyword(s):  
Blood Pressure ◽  
Oleanolic Acid ◽  
Ex Vivo ◽  
Biological Activities ◽  
Cardiovascular Prevention ◽  
In Vivo Studies ◽  
Antihypertensive Activity ◽  
In Vitro Tests

Background:: Hypertension is a high prevalent chronic disease worldwide and a major cardiovascular risk factor. Oleanolic acid (3β-hydroxy-olea-12-en-28-oic acid) is a wide distributed bioactive pentacyclic triterpenoid with diverse biological activities such as anti-inflammatory, hepaprotective anti-diabetic or anti-hypertensive. Objective:: The aim of this study was to review and highlight the available data about antihypertensive activity of oleanolic acid and the described mechanisms of action. Method:: Extensive searches were made in the available literature on oleanolic acid and the data investigating its antihypertensive effects were analysed. Results:: Most of research has been performed on animal models of hypertension, ex vivo studies with aortic ring and some in vitro tests with cell cultures, whereas clinical trials are still lacking. Treatment of hypertensive animals with oleanolic acid significantly ameliorated the rise in the systolic blood pressure. In addition, the hypotensive effects of oleanolic acid are also related to a potent diuretic-natriuretic activity and nephroprotection. In vitro studies have characterized the participation of various signalling pathways that modulate the release of vasodilation mediators. Conclusion:: In vitro and in vivo studies suggest that oleanolic acid effectively reduce blood pressure and could be an interesting co-adjuvant to conventional treatment of hypertension.

scholarly journals Novel antitumor antibiotics, saptomycins. I. Taxonomy of the producing organism, fermentation, HPLC analysis and biological activities.

1993 ◽  
Vol 46 (10) ◽  
pp. 1530-1535 ◽  
Author(s):  
NAOKI ABE ◽  
YASUKAZU NAKAKITA ◽  
TAKEHIKO NAKAMURA ◽  
NOBUYASU ENOKI ◽  
HIDEAKI UCHIDA ◽  
...  
Keyword(s):  
Hplc Analysis ◽  
Biological Activities ◽  
Antitumor Antibiotics

A Review on Recent Developments in the Anticancer Potential of Oleanolic acid and its analogs (2017-2020)

2021 ◽  
Vol 21 ◽  
Author(s):  
Nidhi Gupta
Keyword(s):  
Clinical Trials ◽  
Natural Product ◽  
Oleanolic Acid ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Pentacyclic Triterpenoid ◽  
Recent Developments ◽  
Anti Inflammatory ◽  
Pharmaceutical Properties

: Oleanolic acid (OA) is a pentacyclic triterpenoid class of natural product known to possess a broad range of biological activities, specifically, anticancer. Considering the anticancer potential of OA, a large number of analogs have been prepared by several researchers through modifications at C-3, C-12 and C-28 –COOH to develop the potent anticancer agents with improved cytotoxicity and pharmaceutical properties. Some of the synthesized derivatives have been assessed in clinical trials also. This review summarizes the most recent synthetic and biological efforts in the development of oleanolic acid and its analogs during the period 2017-2020. Reports published during this period revealed that both OA and its analogs possess a remarkable potential for the development of effective anticancer agents along with several others such as anti-inflammatory, anti-viral, anti-microbial and anti-diabetic agents.

scholarly journals Profiling of the Major Phenolic Compounds and Their Biosynthesis Genes in Sophora flavescens Aiton

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jeongyeo Lee ◽  
Jaeeun Jung ◽  
Seung-Hyun Son ◽  
Hyun-Bi Kim ◽  
Young-Hee Noh ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Phenolic Acid ◽  
Hplc Analysis ◽  
Developmental Stages ◽  
Biological Activities ◽  
Expression Patterns ◽  
Coumaric Acid ◽  
Sophora Flavescens ◽  
Catechin Hydrate ◽  
Aerial Parts

Sophorae Radix (Sophora flavescens Aiton) has long been used in traditional medicine in East Asia due to the various biological activities of its secondary metabolites. Endogenous contents of phenolic compounds (phenolic acid, flavonol, and isoflavone) and the main bioactive compounds of Sophorae Radix were analyzed based on the qualitative HPLC analysis and evaluated in different organs and at different developmental stages. In total, 11 compounds were detected, and the composition of the roots and aerial parts (leaves, stems, and flowers) was significantly different. trans-Cinnamic acid and p-coumaric acid were observed only in the aerial parts. Large amounts of rutin and maackiain were detected in the roots. Four phenolic acid compounds (benzoic acid, caffeic acid, ferulic acid, and chlorogenic acid) and four flavonol compounds (kaempferol, catechin hydrate, epicatechin, and rutin) were higher in aerial parts than in roots. To identify putative genes involved in phenolic compounds biosynthesis, a total of 41 transcripts were investigated. Expression patterns of these selected genes, as well as the multiple isoforms for the genes, varied by organ and developmental stage, implying that they are involved in the biosynthesis of various phenolic compounds both spatially and temporally.

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