Nanotechnology has toppled the world, revolutionizing almost every field such as biology, physics, chemistry, mathematics, engineering, industry, medicine, pharmacology, dentistry, and many more. The “Maxwell’s demons” as the nanoparticles were called earlier, have helped humankind in achieving profound effects by manipulation of the materials in the nanoscale. The concept of nanotechnology has left almost no field untouched. Ever since the advent of the term “nanodentistry” by R.A Freitas Jr. in the year 2000, the applications of nanotechnology have been incorporated in the field of dentistry, striving its best to develop better diagnostic, treatment, and maintenance systems in oral health care. This article discusses the various applications of nanodentistry in an interdisciplinary approach.