Granulomatous Dermatitis Associated With Rubella Virus Infection in an Adult With Immunodeficiency

2021 ◽  
Author(s):  
Bridget E. Shields ◽  
Ludmila Perelygina ◽  
Sara Samimi ◽  
Paul Haun ◽  
Thomas Leung ◽  
...  
Keyword(s):  
Virus Infection ◽  
Rubella Virus ◽  
Rubella Virus Infection ◽  
Granulomatous Dermatitis

scholarly journals Sero-prevalence of unvaccinated adolescent girls susceptible to rubella virus infection seen in a tertiary care hospital of Patna, Bihar, India

2020 ◽  
Vol 9 (5) ◽  
pp. 1972
Author(s):  
Dipali Prasad ◽  
Nidhi Prasad ◽  
Vidyut Prakash ◽  
Sadia Parveen ◽  
Urvashi Mishra
Keyword(s):  
Virus Infection ◽  
Adolescent Girls ◽  
Rubella Virus ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Reproductive Age ◽  
Care Hospital ◽  
Rubella Infection ◽  
Area Of Interest ◽  
Rubella Virus Infection

Background: Rubella infection occurring during early pregnancy results in congenital rubella syndrome (CRS).  WHO estimates that worldwide more than 100,000 children are born with CRS each year and most of them are in the developing countries. For assessing population immunity against rubella, sero-surveys are generally recommended among adolescent girls and reproductive age female. In India, sero-surveys conducted by different authors have indicated that about 10-30% of adolescent females are susceptible to rubella infection. Adolescent girls are selected because they are at a critical stage of child bearing age and their immunity against Rubella infection is the particular area of interest. objective of this study was to estimate the sero-prevalence of unvaccinated adolescent girls susceptible to Rubella virus infection attending a tertiary care hospital of Patna and then accordingly counsel for vaccination.Methods: A total 150 adolescent girls in the age group of 10-19 years who had not received MMR vaccine were included in the study. Serum IgG antibody titer for rubella was estimated by the ELISA method.Results: A total 65.33% of the adolescent girls were found to be rubella seropositive and (34.67%) were seronegative. The urban adolescent girls had a higher seropositivity of 85.2% as compared to rural adolescent girls.Conclusions: The study indicates that a substantial number of adolescents (34.67%) are seronegative and hence susceptible to rubella infection.

scholarly journals CHARACTERIZATION OF A HUMAN ACUTE PHASE PROTEIN FOUND IN ASSOCIATION WITH RUBELLA VIRUS INFECTION

1974 ◽  
Vol 139 (3) ◽  
pp. 497-511 ◽  
Author(s):  
Roger Cappel ◽  
Ann Schluederberg ◽  
Robert H. Gifford ◽  
Dorothy M. Horstmann
Keyword(s):  
Rheumatoid Arthritis ◽  
Virus Infection ◽  
Acute Phase ◽  
Rubella Virus ◽  
Acute Phase Protein ◽  
Phase Protein ◽  
Rubella Virus Infection ◽  
In Pregnancy

A precipitating antigen, rho, was first detected in the blood of persons with rubella and in rubella virus-infected cell culture fluids (1). Partially purified antigens from both sources were examined and shown to have similar properties, although antigen from serum sedimented more heterogeneously, with estimated coefficients from 15 to 21 S, while that from culture fluids sedimented in the 11–14 S region. In each case, antigen was located in the ß-1 zone after electrophoresis in agarose, and at a density of 1.305 g/ml after centrifugation in CsCl. Stability characteristics were typical of protein antigens. Immunofluorescent microscopy revealed that rubella virus induced the appearance of rho antigen scattered throughout the cytoplasm of infected cells. When cells containing antigen were exposed for 24 h to 5 µg/ml actinomycin D rho was no longer detectable, indicating the probable cellular origin of the antigen. Also, titers in medium of infected cultures showed a reduction after actinomycin treatment, but levels of the virus-specified antigen, iota, were relatively unaffected. Rho appears to be a protein common to man and many animals. In vitro, it was induced by rubella virus and by adenovirus. In vivo, rho titers were shown to be elevated after rubella virus infection and, to a lesser extent, after infection with certain other viruses. High titers were also demonstrated in women late in pregnancy and in patients with rheumatoid arthritis. In man and the chimpanzee, the appearance and decline of rho in the blood after rubella virus infection were temporally similar to the patterns of CRP, although rho seemed to be a more sensitive indicator of infection. The data presented indicate that rho is a newly recognized acute phase protein inducible by certain virus infections and by other unidentified stimuli present prominently in pregnancy and rheumatoid arthritis.

scholarly journals Antiviral Activity of Geopropolis Extract from Scaptotrigona Aff. Postica against Rubella Virus

2018 ◽  
Vol 7 (6) ◽  
pp. 91 ◽  
Author(s):  
Guilherme Rabelo Coelho ◽  
Cristina Adelaide Figueiredo ◽  
Giuseppina Negri ◽  
Caroline C. Fernandes-Silva ◽  
Karina De Senna Villar ◽  
...  
Keyword(s):  
Virus Infection ◽  
Antiviral Activity ◽  
Rubella Virus ◽  
First Trimester ◽  
Antiviral Effect ◽  
Cell Receptor ◽  
Bioactive Substances ◽  
Propolis Extract ◽  
Rubella Virus Infection ◽  
Simplex Virus

The search for functional foods, which possess bioactive substances, is a new trend for the obtention of alternative and more effective treatments of many diseases with fewer side effects. Geopropolis, elaborated by stingless bees, is a mixture of plant resin sources, wax and soil. In the geopropolis from Scaptotrigona affinis postica (Latreille, 1807), (Hymenoptera, Apidae, Meliponini) was not observed the presence of soil. In a previous study, the extract of geopropolis provided by the beekeeper, from S. postica of Barra do Corda, Maranhão State, exhibited potent antiviral activity against herpes simplex virus. In this study, the propolis extract was prepared experimentally and characterized by RP-HPLC-DAD-ESI-MS/MS. The objective of this study was to evaluate the antiviral activity of an experimentally prepared geopropolis extract from S. postica against Rubella Virus infected Statens Serum Institute Rabbit Cornea (SIRC) cells. Rubella virus infection of susceptible women during the first trimester of pregnancy, often results in a combination of birth defects in newborns. There is not an effective treatment for rubella virus infection. Different protocols were carried out to evaluate, the antiviral effect of geopropolis extract on the viral replication of infectious RV. Cell viability and cell proliferation assays indicated that this geopropolis was not toxic to cultured SIRC cells. In the viral binding assay, antiviral assay, real-time PCR, and transmission electron microscopy, was observed that different concentrations of geopropolis (17, 34 and 68 µg/mL) was able to inhibit the binding of virions to the cell receptor and the production of infectious RV particles in post treated and pre treated infected SIRC cells. The antiviral activity could to be attributed to the high contents of the apigenin derivatives, vicenin-2 and schaftoside. As far as we know, this is the first report about the antiviral activity of geopropolis from Scaptotrigona postica against a Togaviridae virus.

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