Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder

Uninfected dogs and those naturally infected with Leishmania chagasi exhibiting different clinical forms of disease were evaluated for the presence of anti-Neospora caninum and anti-Toxoplasma gondii antibodies. Blood samples were collected from 110 mongrel dogs. Sera were tested using the indirect fluorescent antibody test (IFAT), and the animals with visceral leishmaniasis (VL) (n=60) were classified clinically. Out of the 110 sera investigated, 5 (4.5%) were positive for N. caninum (IFAT>50) and 36 (32.7%) for T. gondii (IFAT>16). Anti-L. chagasi antibody titers in asymptomatic dogs (n=10) were found to be significantly lower (P<0.05) than those in oligosymptomatic ones (n=22), which were in turn significantly lower (P<0.05) than those in symptomatic ones (n=28). No association between Leishmania and N. caninum infections was observed. Among dogs infected with L. chagasi, a tendency (P=0.053) towards an association between the infection with T. gondii and the appearance of VL symptoms was observed, suggesting that the clinical manifestation of VL in dogs may enhance their susceptibility to T. gondii. The possible influence of the immunosuppressive status of canine leishmaniasis in the different clinical forms of the disease is discussed.

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High correlation in antibody titers between the Sabin-Feldman dye test and an enzyme-linked immunosorbent assay detecting immunoglobulin G antibodies to the nucleoside triphosphate hydrolase of Toxoplasma gondii.

Journal of Clinical Microbiology ◽

10.1128/jcm.30.5.1291-1293.1992 ◽

1992 ◽

Vol 30 (5) ◽

pp. 1291-1293 ◽

Cited By ~ 11

Author(s):

T Asai ◽

F Mizuno ◽

S Kojima ◽

T Takeuchi ◽

A Kobayashi ◽

...

Keyword(s):

Toxoplasma Gondii ◽

Immunosorbent Assay ◽

Immunoglobulin G ◽

Enzyme Linked Immunosorbent Assay ◽

Nucleoside Triphosphate ◽

Antibody Titers

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Toxoplasma gondii as a prevalent model for a positive history of mental illness

10.31234/osf.io/utjhz ◽

2018 ◽

Author(s):

Mladen Cimesa

Keyword(s):

Bipolar Disorder ◽

Mental Illness ◽

Toxoplasma Gondii ◽

Mental Disorders ◽

Antisocial Behavior ◽

Mental Illnesses ◽

Abnormal Behavior ◽

Positive History ◽

Proper Functioning ◽

History Of

Toxoplasma gondii is a parasite, specifically single-celled intracellular protozoa. His presence is recorded in most warm-blooded organisms, and therefore also in humans. T gondii has developed a special brain tropism, so this parasite is closely linked to mental illness. The correlation between T gondii and schizophrenia is at the forefront of research and is supported by many evidence, but further research points to other psychopathologies such as bipolar disorder and depression. The prevalence of T gondi is found in the form of antisocial behavior in which we include aggression as well as the percentage of suicides that are also detected. Toxoplasmosis is a parasite that plays a role in etiopathogenesis because it sabotages the proper functioning of the neurotransmitter, especially dopamine, which is one of the determinants of mental illness because its irregular and disruptive secretion induces abnormal behavior. This paper deals with the demonstration of the connection between T gondii and mental illnesses in order to better understand the pathogenesis of certain mental disorders caused by this parasite, and points to caution and prevention

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Seroprevalence of toxoplasma gondii in Romanian psychiatric patients

European Psychiatry ◽

10.1016/j.eurpsy.2017.01.1613 ◽

2017 ◽

Vol 41 (S1) ◽

pp. s825-s825 ◽

Cited By ~ 1

Author(s):

T.R. Olariu ◽

I.D. Capraru ◽

I. Papava ◽

R. Romosan ◽

L. Dehelean ◽

...

Keyword(s):

Bipolar Disorder ◽

Toxoplasma Gondii ◽

Psychiatric Disorders ◽

Psychotic Disorder ◽

Psychiatric Patients ◽

Psychiatric Clinic ◽

High Prevalence ◽

Laboratory Investigations ◽

Competing Interest ◽

Toxoplasma Gondii Infection

IntroductionToxoplasma gondii infection has been recently associated with schizophrenia and other psychiatric disorders.AimThe aim of the present study was to evaluate the prevalence of T. gondii antibodies among acute psychiatric patients from Western Romania.MethodsThis study included 214 consecutive patients admitted at the psychiatric clinic, Country Clinical Emergency Hospital in Timisoara, Romania, between 30.06.2011 and 12.01.2012. Clinical and laboratory investigations were performed in these hospitalized patients, including serologic tests for T. gondii IgG and IgM antibodies.ResultsThe 214 patients aged 19 to 71 years (mean = 42.5), 64.9% were females. T. gondii antibodies were detected in 117 (54.7%) of 214 psychiatric patients. When the data were analyzed by diagnostic groups, T. gondii antibodies were demonstrated in 30 (50.84%) of 59 patients with schizophrenia, in 28 (59.57%) of 47 with persistent delusional disorder, 10 (31.25%) of 32 with acute and transient psychotic disorder, 13 (54.16%) of 24 with schizoaffective disorder and 35 (70%) of 50 with bipolar disorder. A high prevalence of T. gondii antibodies was found among patients with bipolar disorder compared to those with schizophrenia (P = 0.043) acute and transient psychotic disorder (P < 0.0001) and healthy controls (P < 0.0001). Of the 18 patients with schizophrenia and a BPRS score <51, T. gondii antibodies were detected in 13 (72.2%) compared to 17 (41.4%) of 41 in whom BPRS score was >51 (P = 0.03).ConclusionThese findings suggest that T. gondii infection may be associated with several psychiatric disorders. A high seroprevalence of T. gondii was demonstrated in patients with bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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