Seroprevalence of toxoplasma gondii in Romanian psychiatric patients

2017 ◽  
Vol 41 (S1) ◽  
pp. s825-s825 ◽  
Author(s):  
T.R. Olariu ◽  
I.D. Capraru ◽  
I. Papava ◽  
R. Romosan ◽  
L. Dehelean ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Psychiatric Disorders ◽  
Psychotic Disorder ◽  
Psychiatric Patients ◽  
Psychiatric Clinic ◽  
High Prevalence ◽  
Laboratory Investigations ◽  
Competing Interest ◽  
Toxoplasma Gondii Infection

IntroductionToxoplasma gondii infection has been recently associated with schizophrenia and other psychiatric disorders.AimThe aim of the present study was to evaluate the prevalence of T. gondii antibodies among acute psychiatric patients from Western Romania.MethodsThis study included 214 consecutive patients admitted at the psychiatric clinic, Country Clinical Emergency Hospital in Timisoara, Romania, between 30.06.2011 and 12.01.2012. Clinical and laboratory investigations were performed in these hospitalized patients, including serologic tests for T. gondii IgG and IgM antibodies.ResultsThe 214 patients aged 19 to 71 years (mean = 42.5), 64.9% were females. T. gondii antibodies were detected in 117 (54.7%) of 214 psychiatric patients. When the data were analyzed by diagnostic groups, T. gondii antibodies were demonstrated in 30 (50.84%) of 59 patients with schizophrenia, in 28 (59.57%) of 47 with persistent delusional disorder, 10 (31.25%) of 32 with acute and transient psychotic disorder, 13 (54.16%) of 24 with schizoaffective disorder and 35 (70%) of 50 with bipolar disorder. A high prevalence of T. gondii antibodies was found among patients with bipolar disorder compared to those with schizophrenia (P = 0.043) acute and transient psychotic disorder (P < 0.0001) and healthy controls (P < 0.0001). Of the 18 patients with schizophrenia and a BPRS score <51, T. gondii antibodies were detected in 13 (72.2%) compared to 17 (41.4%) of 41 in whom BPRS score was >51 (P = 0.03).ConclusionThese findings suggest that T. gondii infection may be associated with several psychiatric disorders. A high seroprevalence of T. gondii was demonstrated in patients with bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Multiple sclerosis and psychiatric disorders: Comorbidity and sibling risk in a nationwide Swedish cohort

2014 ◽  
Vol 20 (14) ◽  
pp. 1881-1891 ◽  
Author(s):  
Viktoria Johansson ◽  
Cecilia Lundholm ◽  
Jan Hillert ◽  
Thomas Masterman ◽  
Paul Lichtenstein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bipolar Disorder ◽  
Psychiatric Disorders ◽  
Psychiatric Patients ◽  
Familial Risk ◽  
Positive Association ◽  
Protective Mechanisms ◽  
Genetic Liability ◽  
Sibling Comparison ◽  
National Patient

Background: Psychiatric disorders are known to be prevalent in multiple sclerosis (MS). Objective: The objective of this paper is to study comorbidity between MS and bipolar disorder, schizophrenia and depression in a nationwide cohort and to determine whether shared genetic liability underlies the putative association. Methods: We identified ICD-diagnosed patients with MS ( n = 16,467), bipolar disorder ( n = 30,761), schizophrenia ( n = 22,781) and depression ( n = 172,479) in the Swedish National Patient Register and identified their siblings in the Multi-Generation Register. The risk of MS was compared in psychiatric patients and in matched unexposed individuals. Shared familial risk between MS and psychiatric disorders was estimated by sibling comparison. Results: The risk of MS was increased in patients with bipolar disorder (hazard ratio (HR) 1.8, 95% confidence interval (CI) 1.6–2.2, p < 0.0001) and depression (HR 1.9, 95% CI 1.7–2.0, p < 0.0001). MS risk in schizophrenia was decreased (HR 0.6, 95% CI 0.4–0.9, p = 0.005). The association between having a sibling with a psychiatric disorder and developing MS was not significant. Conclusion: We found a strong positive association between MS and bipolar disorder and depression that could not be explained by genetic liability. The unexpected negative association between MS and schizophrenia might be spurious or indicate possible protective mechanisms that warrant further exploration.

scholarly journals Immunoglobulin sub-class distribution in bipolar disorder and schizophrenia: potential relationship with latent Toxoplasma Gondii infection

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Nora Hamdani ◽  
Djaouida Bengoufa ◽  
Ophélia Godin ◽  
Raphaël Doukhan ◽  
Emmanuel Le Guen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Class Distribution ◽  
Potential Relationship ◽  
Toxoplasma Gondii Infection

Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis

2017 ◽  
Vol 209 ◽  
pp. 59-65 ◽  
Author(s):  
João Luís Vieira Monteiro de Barros ◽  
Izabela Guimarães Barbosa ◽  
Haitham Salem ◽  
Natalia Pessoa Rocha ◽  
Arthur Kummer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Toxoplasma Gondii Infection

High Prevalence of Viable Toxoplasma gondii Infection in Market Weight Pigs from a Farm in Massachusetts

2002 ◽  
Vol 88 (6) ◽  
pp. 1234 ◽  
Author(s):  
J. P. Dubey ◽  
H. R. Gamble ◽  
D. Hill ◽  
C. Sreekumar ◽  
S. Romand ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
High Prevalence ◽  
Toxoplasma Gondii Infection

Association between Toxoplasma gondii infection and psychiatric disorders in Zhejiang, Southeastern China

Acta Tropica ◽  
2019 ◽  
Vol 192 ◽  
pp. 82-86 ◽  
Author(s):  
Xiaojian Chen ◽  
Bi Chen ◽  
Xiangqing Hou ◽  
Cunqing Zheng ◽  
Xunjun Yang ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Psychiatric Disorders ◽  
Southeastern China ◽  
Toxoplasma Gondii Infection

Perceptual symptoms in the latino psychiatric patients attending inner city outpatient clinic

2016 ◽  
Vol 33 (S1) ◽  
pp. S401-S401
Author(s):  
L. Gonzalez ◽  
A. Khadivi ◽  
W. Gu ◽  
P. Korenis
Keyword(s):  
Psychiatric Patients ◽  
Cultural Beliefs ◽  
Significant Proportion ◽  
Psychotic Symptoms ◽  
Psychiatric Clinic ◽  
Latino Population ◽  
Psychotic Illness ◽  
Cultural Backgrounds ◽  
Retrospective Case ◽  
Competing Interest

IntroductionPsychotic symptoms occur in a variety of psychiatric disorders and medical conditions. In addition, a significant proportion of the general population reports history of psychotic symptoms in the apparent absence of a psychiatric disorder. Reviewed literature suggests that Latino patients report certain forms of visual and auditory hallucinations without other indications of psychotic illness. In addition, it is common that some individuals with diverse religious or cultural backgrounds may present with psychotic transient experiences, which can be culturally normative.ObjectiveTo determine the prevalence of hallucinations and describe the nature of hallucinatory experiences in relation to cultural belief in Latino and non-Latino psychiatric outpatients.MethodsWe conducted a retrospective case control study of 146 patients who were admitted to the outpatient psychiatric clinic for a period of ten months. We assessed clinical characteristics of these patients and reviewed the extended mental status examination, which contained questions about various form of hallucinations and spiritual experiences. This poster will explore the prevalence of hallucinations in the Latino population and determine the percentage of patients with a diagnosis of psychotic illness. A discussion of the phenomenological hallucinatory experiences and its relationship to cultural beliefs in the Latino psychiatric patients will also be presented.ConclusionsPsychotic symptoms present differently across cultures. The Latino population is most likely to have psychotic like symptoms related to their cultural beliefs. Clinicians must understand the diverse cultural experiences and beliefs of the patients they work with to prevent misdiagnosis of culturally normative experiences.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Most frequent clinic comorbibities in hospitalized patients in a psychiatric clinic

2016 ◽  
Vol 33 (S1) ◽  
pp. S379-S379
Author(s):  
J. Jaber ◽  
J. Veríssimo ◽  
T.T. Raposo ◽  
B. Reys
Keyword(s):  
Psychiatric Patients ◽  
Time Frame ◽  
Health Condition ◽  
Physical Activities ◽  
Hospitalized Patients ◽  
Psychiatric Clinic ◽  
Minimum Period ◽  
Global Improvement ◽  
Patient Health ◽  
Competing Interest

IntroductionBeing hospitalized in a psychiatric clinic, patients present, in addition to the diseases that determine the hospitalization, clinic comorbidities, generally decompensated.ObjectivesTo present the most frequent clinic pathologies in a population of hospitalized patients having diverse mental disorders and establish a protocol for investigation and their early treatment.AimsTo know the most frequent pathologies in a population of hospitalized psychiatric patients and establish a protocol for their assesment, in a way that contributes to the global improvement of the patient health condition.MethodsFor its mission realization, the clinic counts on a multidisciplinary team. The participants were 762 patients, seen in the referred clinic, which presented a minimum period of hospitalization of 10 days and that were submitted to thorough clinic exam and complementary routine exams. The time frame referred to the period of March of 2012 to February of 2014, totalizing 24 months.ResultsIn the patients that had medical release after periods of hospitalization of, 90-day average, were obtained, in the totality of the cases, excellent evolution, evidenced by the improvement of the laboratory parameters.ConclusionsThe results were achieved in the hospitalization system with careful medicament administration, differentiated diets established in agreement with the patients, supervised physical activities and psychological and psychiatric support.Disclosure of interestThe authors have not supplied their declaration of competing interest.

2285Increased risk of out-of-hospital cardiac arrest associated with psychiatric disorders

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
C A Barcella ◽  
G H Mohr ◽  
K Kragholm ◽  
D M Christensen ◽  
C Polcwiartek ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiac Arrest ◽  
High Risk ◽  
General Population ◽  
Mental Disorders ◽  
Personality Disorders ◽  
Psychiatric Disorders ◽  
Index Date ◽  
Psychiatric Patients ◽  
Hospital Cardiac Arrest

Abstract Introduction Patients with psychiatric disorders are at high risk of cardiovascular morbidity and mortality; yet, the risk of out-of-hospital cardiac arrest (OHCA) compared to the general population remains unknown. Purpose We investigated whether the presence and severity of different psychiatric disorders were associated with a higher risk of OHCA. Methods We conducted a case-control study matching all adult patients with OHCA of presumed cardiac cause between 2001 and 2014 with up to nine controls from the entire Danish population on age, sex and ischemic heart disease (IHD). Patients with psychiatric disorders were identified using in- and out-patient hospital diagnoses – both primary and secondary - before index date. We identified six mutually exclusive psychiatric disorders that were separately examined: personality disorders, anxiety, substance-related mental disorders, depression, bipolar disorder and schizophrenia. The risk of OHCA associated with the six psychiatric disorders was evaluated by conditional logistic regression adjusting for comorbidities, concomitant pharmacotherapy, socioeconomic status and marital status. Results We included 32,447 OHCA cases matched with 291,999 controls from the general population. Overall, the median age was 72 years, 67% were male and 29% had IHD prior to index date. All the six psychiatric disorders examined were more common among cases than controls; depression was the most common psychiatric disorders in both groups: 5.0% among cases and 2.8% among controls. Concurrently, all six psychiatric disorders were associated with significantly higher odds of OHCA: personality disorders (odds ratio (OR) 1.30 [95% confidence interval (CI) 1.06–1.60], anxiety OR 1.26 [95% CI 1.15–1.39], substance induced-mental disorders OR 2.36 [95% CI 2.17–2.57], depression OR 1.27 [95% CI 1.19–1.35], bipolar disorder OR 1.32 [95% CI 1.16–1.50] and schizophrenia OR 1.80 [95% CI 1.58–2.05] (Figure). The association persisted unaffected when we studied psychiatric patients neither exposed to antipsychotics nor to antidepressants. We observed a trend towards a stronger association when we stratified according to the severity of the psychiatric disorder (Figure). Severe disorders where classified as at least one hospitalization for the specific psychiatric illness as primary diagnosis during the five years prior to index date. Conclusions Common psychiatric disorders including personality disorders, anxiety, substance-related mental disorders, depression, bipolar disorder and schizophrenia are significantly associated with higher odds of OHCA. These findings provide a rationale for early cardiovascular risk factor screening and, potentially, management among psychiatric patients to identify patients at high risk of OHCA. Acknowledgement/Funding ESCAPE-NET project

Connectivity differences between bipolar disorder, unipolar depression and schizophrenia

2017 ◽  
Vol 41 (S1) ◽  
pp. S348-S348
Author(s):  
S. Metin ◽  
B. Metin ◽  
C. Tas ◽  
N. Tarhan
Keyword(s):  
Bipolar Disorder ◽  
Corpus Callosum ◽  
Psychiatric Disorders ◽  
Diffusion Tensor ◽  
Internal Capsule ◽  
Unipolar Depression ◽  
Limited Data ◽  
Schizophrenia Group ◽  
Competing Interest ◽  
Diffusion Tensor Imaging Dti

IntroductionDiffusion tensor imaging (DTI) is used frequently to explore white matter tract morphology and connectivity in psychiatric disorders. Connectivity alterations were previously reported for bipolar disorder, unipolar depression and schizophrenia. However, there is limited data on how these disorders differ from one another in terms of connectivity.AimsIn this study, we aimed to explore connectivity differences between these disorders.MethodsWe analyzed DTI data of 37 patients with schizophrenia, 41 patients with bipolar disorder and 46 patients with unipolar depression. Group analyses were performed for schizophrenia versus bipolar and bipolar versus unipolar contrasts with using age as a covariate.ResultsThreshold corrected results showed that connectivity at internal capsule and corpus callosum were most distinctive between groups. For corpus callosum (splenium), unipolar group showed the highest connectivity and schizophrenia group showed the lowest connectivity (Fig. 1). For internal capsule, schizophrenia group had the highest connectivity and unipolar group had the lowest connectivity (Fig. 2). Bipolar group had intermediate values for both tracts.ConclusionsThese results indicate that connectivity analysis may be helpful for differentiating psychiatric disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Prevalence of Psychopathological Features in Intellectual Diability: The Italian SPAID-G Multicentric Study

2017 ◽  
Vol 41 (S1) ◽  
pp. S92-S93
Author(s):  
D. Scuticchio ◽  
M.O. Bertelli ◽  
G. Chiodelli ◽  
R. Cavagnola ◽  
F. Manna
Keyword(s):  
Psychiatric Disorders ◽  
Cost Effective ◽  
Daily Practice ◽  
Diagnostic Tools ◽  
Italian Population ◽  
Multicentric Study ◽  
High Prevalence ◽  
Dsm Iv ◽  
Competing Interest ◽  
Italian Sample

IntroductionDespite increasing awareness of high prevalence of psychiatric disorders in people with intellectual disability (ID), diagnostic tools are few and scarcely used in daily practice. SPAID-G (psychiatric instrument for the intellectually disabled adult-general version) is the first Italian for carrying out psychiatric diagnostic orientations in adults with ID. It was designed to be easy and quick instrument for daily clinical practice.Objectives/AimsThe present study was aimed at evaluating psychometric and psychodiagnostic characteristics of the SPAID-G and at supplying new data on the prevalence rate of psychiatric disorders in a multicentric Italian sample of people with ID living in different settings.MethodsThe SPAID-G was consecutively administered to more than 800 persons with ID attending residential, rehabilitative or clinical services across Italy. A part of the sample was also assessed for psychopathology through the use of DASH-II, PDD-MRS and clinically diagnosed in accordance to DSM-IV-TR and DSM-5 criteria.ResultsSPAID internal consistency, inter-rater reliability and concordance with DASH-II and PDD-MRS resulted to be good. Around 40% of the sample was assessed to have a cluster of psychopathological symptoms that could be consistent with a psychiatric diagnosis. Autism, impulse control disorder and personality disorder resulted to be the most frequent over threshold scores.ConclusionsThe SPAID-G seems to be a valid and cost-effective screening tool for the psychiatric assessment within the Italian population with ID.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Sign in / Sign up

Export Citation Format

Share Document