scholarly journals An Investigation into the Association Between Toxoplasma gondii Infection and Bipolar Disorder

2021 ◽  
Vol 45 (4) ◽  
pp. 241-246
Author(s):  
Mümtaz Cem Şirin ◽  
Faruk Kılıç ◽  
Arif Demirdaş ◽  
Buket Arıdoğan ◽  
Emel Sesli Çetin
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii

scholarly journals Is Toxoplasma gondii a Trigger of Bipolar Disorder?

Pathogens ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 3 ◽  
Author(s):  
Claudia Del Grande ◽  
Luca Galli ◽  
Elisa Schiavi ◽  
Liliana Dell’Osso ◽  
Fabrizio Bruschi
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii

scholarly journals Immunoglobulin sub-class distribution in bipolar disorder and schizophrenia: potential relationship with latent Toxoplasma Gondii infection

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Nora Hamdani ◽  
Djaouida Bengoufa ◽  
Ophélia Godin ◽  
Raphaël Doukhan ◽  
Emmanuel Le Guen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Class Distribution ◽  
Potential Relationship ◽  
Toxoplasma Gondii Infection

Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis

2017 ◽  
Vol 209 ◽  
pp. 59-65 ◽  
Author(s):  
João Luís Vieira Monteiro de Barros ◽  
Izabela Guimarães Barbosa ◽  
Haitham Salem ◽  
Natalia Pessoa Rocha ◽  
Arthur Kummer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Toxoplasma Gondii Infection

Antibodies to Toxoplasma gondii and Cognitive Functioning in Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls

2014 ◽  
Vol 202 (8) ◽  
pp. 589-593 ◽  
Author(s):  
Faith Dickerson ◽  
Cassie Stallings ◽  
Andrea Origoni ◽  
Emily Katsafanas ◽  
Lucy Schweinfurth ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Cognitive Functioning

scholarly journals Association of Cytomegalovirus and Toxoplasma gondii Antibody Titers With Bipolar Disorder

2019 ◽  
Vol 76 (12) ◽  
pp. 1285 ◽  
Author(s):  
Mark A. Frye ◽  
Brandon J. Coombes ◽  
Susan L. McElroy ◽  
Lori Jones-Brando ◽  
David J. Bond ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Antibody Titers

Toxoplasma gondii as a prevalent model for a positive history of mental illness

2018 ◽  
Author(s):  
Mladen Cimesa
Keyword(s):  
Bipolar Disorder ◽  
Mental Illness ◽  
Toxoplasma Gondii ◽  
Mental Disorders ◽  
Antisocial Behavior ◽  
Mental Illnesses ◽  
Abnormal Behavior ◽  
Positive History ◽  
Proper Functioning ◽  
History Of

Toxoplasma gondii is a parasite, specifically single-celled intracellular protozoa. His presence is recorded in most warm-blooded organisms, and therefore also in humans. T gondii has developed a special brain tropism, so this parasite is closely linked to mental illness. The correlation between T gondii and schizophrenia is at the forefront of research and is supported by many evidence, but further research points to other psychopathologies such as bipolar disorder and depression. The prevalence of T gondi is found in the form of antisocial behavior in which we include aggression as well as the percentage of suicides that are also detected. Toxoplasmosis is a parasite that plays a role in etiopathogenesis because it sabotages the proper functioning of the neurotransmitter, especially dopamine, which is one of the determinants of mental illness because its irregular and disruptive secretion induces abnormal behavior. This paper deals with the demonstration of the connection between T gondii and mental illnesses in order to better understand the pathogenesis of certain mental disorders caused by this parasite, and points to caution and prevention

Seroprevalence of toxoplasma gondii in Romanian psychiatric patients

2017 ◽  
Vol 41 (S1) ◽  
pp. s825-s825 ◽  
Author(s):  
T.R. Olariu ◽  
I.D. Capraru ◽  
I. Papava ◽  
R. Romosan ◽  
L. Dehelean ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Psychiatric Disorders ◽  
Psychotic Disorder ◽  
Psychiatric Patients ◽  
Psychiatric Clinic ◽  
High Prevalence ◽  
Laboratory Investigations ◽  
Competing Interest ◽  
Toxoplasma Gondii Infection

IntroductionToxoplasma gondii infection has been recently associated with schizophrenia and other psychiatric disorders.AimThe aim of the present study was to evaluate the prevalence of T. gondii antibodies among acute psychiatric patients from Western Romania.MethodsThis study included 214 consecutive patients admitted at the psychiatric clinic, Country Clinical Emergency Hospital in Timisoara, Romania, between 30.06.2011 and 12.01.2012. Clinical and laboratory investigations were performed in these hospitalized patients, including serologic tests for T. gondii IgG and IgM antibodies.ResultsThe 214 patients aged 19 to 71 years (mean = 42.5), 64.9% were females. T. gondii antibodies were detected in 117 (54.7%) of 214 psychiatric patients. When the data were analyzed by diagnostic groups, T. gondii antibodies were demonstrated in 30 (50.84%) of 59 patients with schizophrenia, in 28 (59.57%) of 47 with persistent delusional disorder, 10 (31.25%) of 32 with acute and transient psychotic disorder, 13 (54.16%) of 24 with schizoaffective disorder and 35 (70%) of 50 with bipolar disorder. A high prevalence of T. gondii antibodies was found among patients with bipolar disorder compared to those with schizophrenia (P = 0.043) acute and transient psychotic disorder (P < 0.0001) and healthy controls (P < 0.0001). Of the 18 patients with schizophrenia and a BPRS score <51, T. gondii antibodies were detected in 13 (72.2%) compared to 17 (41.4%) of 41 in whom BPRS score was >51 (P = 0.03).ConclusionThese findings suggest that T. gondii infection may be associated with several psychiatric disorders. A high seroprevalence of T. gondii was demonstrated in patients with bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The association between antibodies to neurotropic pathogens and bipolar disorder

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Gijsje J. L. J. Snijders ◽  
Hans C. van Mierlo ◽  
Marco P. Boks ◽  
Marieke J. H. Begemann ◽  
Arjen L. Sutterland ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Risk Factor ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Age Groups ◽  
Igg Antibodies ◽  
Subgroup Analyses ◽  
Hsv 1

AbstractExposure to neurotropic pathogens has been hypothesized to be a risk factor for the development of bipolar disorder (BD). However, evidence so far is inconsistent. We, therefore, analyzed the seroprevalence and titer levels of IgG antibodies against several herpesviruses and Toxoplasma gondii (T. gondii) in plasma of 760 patients with a bipolar disorder, 144 first-degree matched relatives and 132 controls of the Dutch Bipolar (DB) Cohort using ELISA. In addition, we performed a literature-based meta-analysis on the seroprevalence of IgG antibodies against these pathogens (n = 14). Our results in the DB Cohort and subsequent meta-analysis (n = 2364 BD patients, n = 5101 controls) show no association between exposure to herpesviruses and bipolar disorder (HSV-1 [adjusted OR 0.842, 95% CI 0.567–1.230], HSV-2 [adjusted OR 0.877, 95% CI 0.437–1.761], CMV [adjusted OR 0.884 95% CI 0.603–1.295], EBV [adjusted OR 0.968 95% CI 0.658–1.423]). In the DB Cohort, we did not find an association between bipolar disorder and T. gondii titer or seroprevalence either [adjusted OR 1.018, 95% CI 0.672–1.542]. The overall OR was not significant for T. gondii [OR: 1.4, 95% CI 0.95–1.90, p = 0.09), but subgroup analyses in age groups below 40 years showed a significantly increased seroprevalence of T. gondii IgGs in BD [OR: 1.8 (95% CI 1.10–2.89, p = 0.021]. Our meta-analysis indicates that T. gondii exposure may be a risk factor for BD in certain subpopulations.

Relationship between Toxoplasma gondii infection and bipolar disorder in a French sample

2013 ◽  
Vol 148 (2-3) ◽  
pp. 444-448 ◽  
Author(s):  
Nora Hamdani ◽  
Claire Daban-Huard ◽  
Mohamed Lajnef ◽  
Jean-Romain Richard ◽  
Marine Delavest ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Toxoplasma Gondii ◽  
Toxoplasma Gondii Infection
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