Methods for cervical ripening and labour induction in late pregnancy: generic protocol

2009 ◽  
Author(s):  
G Justus Hofmeyr ◽  
Zarko Alfirevic ◽  
Anthony J Kelly ◽  
Josephine Kavanagh ◽  
Jane Thomas ◽  
...  
Keyword(s):  
Late Pregnancy ◽  
Cervical Ripening ◽  
Labour Induction

Methods for cervical ripening and labour induction in late pregnancy: generic protocol

2000 ◽  
Author(s):  
G Justus Hofmeyr ◽  
Zarko Alfirevic ◽  
Anthony J Kelly ◽  
Josephine Kavanagh ◽  
Jane Thomas ◽  
...  
Keyword(s):  
Late Pregnancy ◽  
Cervical Ripening ◽  
Labour Induction

scholarly journals Efficacy and Safety of Vaginal Misoprostol for Cervical Ripening and Labour Induction in Late Pregnancy

KYAMC Journal ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 78-83
Author(s):  
Most Nasrin Nigger ◽  
Sheuly Akter ◽  
Ummul Nusrat Zahan ◽  
Fatema Begum
Keyword(s):  
Neonatal Intensive Care ◽  
Foley Catheter ◽  
Late Pregnancy ◽  
Meconium Aspiration Syndrome ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Efficacy And Safety ◽  
Group I ◽  
Catheter Group ◽  
Misoprostol Group

Background: Induction of labor is its intentional initiation before spontaneous onset, with the aim of vaginal birth which is safe for mother and newborn. The well documented effectiveness of misoprostol in several gynecological and obstetric applications has resulted in enthusiasm for its use. Objective: To see the efficacy and safety vaginal Misoprostal for cervical ripening and labour induction in late pregnancy. Materials and Methods: This single center clinical trial was carried out in the Department of Obstetrics and Gynaecology at Khwaja Yunus Ali Medical College and Hospital in Sirajgonj, Bangladesh from June 2019 to May 2020 for a period of one year. A total of 90 women requiring indicated induction of labour with an unfavourable cervix (Bishop score ≤ 4) were included in the study. They were randomly divided into two groups: 53 women induced with intravaginal misoprostol (Group I) and 37 women induced with transcervical Foley catheter (Group II). Results: Spontaneous vaginal delivery was 35(66.0%) in misoprostol group and 15(40.5%) in Foley catheter group. Caesarean section was higher in Foley catheter group than misoprostol group (37.8% vs 18.9%). The mean birth weight, APGAR score 1 minute, 5 minute, admission in neonatal intensive care unit and meconium aspiration syndrome were not statistically significant between two groups (p>0.05). Only one baby was died in Foley catheter group, but the difference was not statistically significant between two groups (p>0.05). Conclusion: The present study suggests intravaginal Misoprostol results in a shorter induction to delivery time, a reduction in the rate of caesarean delivery. KYAMC Journal.2021;12(02): 78-83

scholarly journals A Comparison of Orally Administered Misoprostol With Vaginally Administered Misoprostol For Cervical Ripening And Labour Induction

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 668-672 ◽  
Author(s):  
Sohana Siddique ◽  
Muhammad Jahangir Howlader ◽  
Joysree Saha ◽  
Kazi Shahnaz Begum
Keyword(s):  
Mode Of Delivery ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Efficacy And Safety ◽  
Cross Sectional ◽  
Oral Misoprostol ◽  
Number Of Patients ◽  
Oral Group ◽  
Vaginal Misoprostol ◽  
Duration Of Pregnancy

Objective: To compare efficacy and safety of oral misoprostol over vaginal misoprostol for labour induction.Materials and Methods: This is a cross sectional interventional hospital based comparative study which was carried in the department of Obstetrics and Gynecology in DMCH from 01.07.2008 to 31.12.2008.Results: Almost equal number of patients delivered vaginally spontaneously in both group, there is no association between route of administration and mode of delivery. Nausea,vomiting occurred more in oral group and uterine hypertonicity more in vaginal group.Conclusion: In this study, 50 patients were randomly selected for oral group and 50 patients for vaginal group. There were no significant differences regarding age, duration of pregnancy, Bishop's score and indication of induction of labour.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 668-672

scholarly journals A comparative study of intra-cervical foley’s catheter and PGE2 gel for induction of labour at term

2019 ◽  
Vol 8 (9) ◽  
pp. 3689
Author(s):  
Anjali R. Kanada ◽  
Mahima Jain
Keyword(s):  
Side Effects ◽  
Caesarean Section ◽  
Comparative Study ◽  
Foley Catheter ◽  
Induction Of Labour ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Mechanical Methods ◽  
Significant Difference ◽  
Foley’S Catheter

Background: In cervical ripening, before induction of labour, is needed to increase the success of labour induction, to reduce complications and to diminish the rate of caesarean section and duration of labour. Pharmacological preparations are in widespread use for cervical ripening but are not free from side-effects and complications. Mechanical methods, i.e. the use of Foley’s catheter balloon, though effective have not gained much popularity because of the fear of infection. Therefore, the study has been conducted to prove the efficacy and safety of extra amniotic Foley catheter balloon and to compare it with intra-cervical prostaglandin E2 (PGE2) gel. The objective of the study was to the success of induction of labor depends on the cervical status at the time of induction. For effective cervical ripening both Foley's catheter and PGE2 gel are used. The aim of this study was to compare the efficacy of intra cervical Foley's catheter and intra cervical PGE2 gel in cervical ripening for the successful induction of labor.Methods: A randomized, comparative study was conducted in the department of obstetrics and gynaecology, Civil hospital, B.J. Medical College Ahmedabad, during a period of 8 month from September 2018 to April 2019. 100 patients at term with a Bishop's score ≤5 with various indications for induction were randomly allocated to group F (intra-cervical Foley’s catheter) and group P (PGE2 gel) with 50 women included in each group.Results: The groups were comparable with respect to maternal age, gestation age, indication of induction and initial Bishop's score. Both the groups showed significant change in the Bishop's score, 5.10±1.55 and 5.14±1.60 for Foley's catheter and PGE2 gel, respectively, p <0.001. However there was no significant difference between the two groups. There was no significant difference in the side effects and caesarean section rate in both groups. The induction to delivery interval was 16.01±5.50 hours in group F and 16.85 ± 3.81 hours in group P (p=0.073). Apgar scores, birth weights and NICU admissions showed no significant difference between the two groups.Conclusions: The study shows that both Foley's catheter and PGE2 gel are equally effective in pre induction cervical ripening.

scholarly journals Use of Misoprostol in Pregnancy- A Review Article

2012 ◽  
Vol 22 (2) ◽  
pp. 94-98
Author(s):  
Syeda Ummay Kulsum ◽  
Sabera Khatun ◽  
SM Shahnawaz Bin Tabib
Keyword(s):  
Prostaglandin E2 ◽  
Review Article ◽  
Induction Of Labour ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Pharmacological Agents ◽  
Tablet Form ◽  
Cytoprotective Agent ◽  
Medicine Today

Prostaglandins are the pharmacological agents used for induction of labour and augmentation of labour. Prostaglandin E2 gel is used for cervical ripening and induction of labour. These are however, costly and need to be stored in a refrigerator at a temperature of 2 - 8°C, half life 18 months. The Tablet form of prostaglandin E2 is not available in Bangladesh. Misoprostol, a synthetic prostaglandin (PG) E1 analogue is used orally for the treatment of gastric and duodenal ulcer and used as a cytoprotective agent. It was first used for labour induction in 1987. Prostaglandin can be used in several gynaecological and obstetric conditions. It can be given through several routes. This article will elaborately delinate the role of misoprostol, a prostaglandin in obstetrics and gynaecological conditions. Medicine Today 2010 Volume 22 Number 02 Page 94-98 DOI: http://dx.doi.org/10.3329/medtoday.v22i2.12443

scholarly journals Comparative study on cervical ripening and labour induction with dinoprostone versus foley’s catheter with extra amniotic saline infusion

2020 ◽  
Vol 9 (10) ◽  
pp. 4080
Author(s):  
Rachel Alexander A. ◽  
Gigi A.
Keyword(s):  
Gestational Age ◽  
Mode Of Delivery ◽  
Cost Effective ◽  
Similar Efficacy ◽  
Saline Infusion ◽  
Induction Of Labour ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Maternal Complications ◽  
Significant Difference

Background: Induction of labour is defined as initiation of uterine contractions before spontaneous onset of labour. This observational study compares the effect of prostaglandin E2 (PGE2) and extra amniotic saline infusion (EASI) for pre-labour ripening of unfavourable uterine cervix.Methods: This was a prospective study conducted on 100 pregnant women with gestational age ≥37 weeks during a year period in the department of obstetrics and gynaecology of government TD medical college, Alappuzha, Kerala. The period of study was for one year from June 2002 to July 2003. All patients were divided into two groups. Group-1 contains 47 patients who received intracervical PGE2, (Dinoprostone gel, 0.5 mg). Group-2 contains 53 patients who were induced with EASI. The main outcome variables were the number of subjects with favourable Bishop's score, mode of delivery, maternal complications and neonatal outcomes.Results: Majority of the patients in both the groups were in the age of 21-30 years. There was significant difference in age, parity and gestational age of both groups. In this study it was found significant difference in the occurrence of hyper stimulation among PGE2 and EASI; whereas, there was no significant difference in the occurrence of maternal pyrexia among two groups. High incidence of caesarean section was found in EASI. APGAR score of new born babies was high in labour induced with PGE2.Conclusions: PGE2 and EASI have similar efficacy in induction of labour, but EASI is associated with more side effects. Cost wise EASI is more cost effective than PGE2.

319. RELAXIN REGULATES AQUAPORIN EXPRESSION IN THE CERVIX OF LATE PREGNANT MICE

2010 ◽  
Vol 22 (9) ◽  
pp. 119
Author(s):  
Y. Soh ◽  
L. J. Parry
Keyword(s):  
Fluid Balance ◽  
Late Pregnancy ◽  
Fold Increase ◽  
Peptide Hormone ◽  
Cervical Ripening ◽  
Aqp5 Expression ◽  
Pregnant Mice ◽  
Wet Weight ◽  
Circulating Levels ◽  
Relaxin Receptor

Aquaporins (AQPs) have been implicated in the regulation of fluid balance in the cervix during pregnancy to promote hydration, a characteristic of cervical ripening in late gestation.There are four AQPs in the cervix; AQP3, 4, 5 and 8. Cervical fluid balance involves AQP5 and 8 in early pregnancy and AQP3 and 4 in late pregnancy [1]. However, the factors involved in the regulation of cervical AQPs are unknown. We propose that the ovarian peptide hormone relaxin regulates cervical AQPs because high circulating levels of relaxin correspond to changes in AQPs and it is involved in cervical ripening. To test this hypothesis, expression of aqp3, 5 and 8 was compared in the cervices of relaxin wildtype (Rln+/+) and relaxin knockout (Rln–/–) at various stages of pregnancy (day 14.5, 16.5 and 18.5 pregnancy) by quantitative PCR. In the Rln–/– mice, aqp3 expression was significantly lower on day 18.5 gestation compared to Rln+/+ littermates. Aqp5 and 8 expression did not change significantly between genotypes. To determine whether relaxin could restore the Rln+/+ phenotype, Rln–/– mice were implanted with Alzet osmotic minipumps on day 12.5 pregnancy to infuse either recombinant H2 human relaxin (200 μg/mL; Corthera Inc) or 0.9% saline as a control. Cervices were collected after 4 or 6 days of infusion for gene expression analysis. Relaxin infusion in pregnant Rln–/– mice increased cervical aqp3, and also decreased aqp5 expression compared with saline-controls in the 6-day infusion group. Additionally, relaxin treatment caused a 6-fold increase in cervix wet weight, dispersal of collagen fibres and a decrease in relaxin receptor (Rxfp1) expression. These data suggest that relaxin promotes cervical hydration through an action on AQPs. (1) Anderson et al, 2006. Endocrinology 147(1): 130–140.

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