Elimination of hepatitis C virus in high‐prevalence, low‐income countries: is it feasible?

2020 ◽  
pp. 216-219
Author(s):  
Mahmoud Abdo ◽  
Hadeel Gamal Eldeen
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Low Income ◽  
Low Income Countries ◽  
High Prevalence

Efficiency of second pegylated interferon and ribavirin combination treatment for the relapsed hepatitis C virus infection in low-income countries

2014 ◽  
Vol 26 (4) ◽  
pp. 493-494 ◽  
Author(s):  
Bahadir Ceylan ◽  
Ferhat Aslan ◽  
Cem Yardimci ◽  
Muzaffer Fincanci ◽  
Nail Özgüneş
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Combination Treatment ◽  
Low Income ◽  
Pegylated Interferon ◽  
Low Income Countries ◽  
Hepatitis C Virus Infection

scholarly journals State of the Art, Unresolved Issues, and Future Research Directions in the Fight against Hepatitis C Virus: Perspectives for Screening, Diagnostics of Resistances, and Immunization

2016 ◽  
Vol 2016 ◽  
pp. 1-19 ◽  
Author(s):  
Cecilia Trucchi ◽  
Andrea Orsi ◽  
Cristiano Alicino ◽  
Laura Sticchi ◽  
Giancarlo Icardi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Low Income ◽  
State Of The Art ◽  
Antiviral Agents ◽  
Screening Strategy ◽  
New Drugs ◽  
Low Income Countries ◽  
Effective Control ◽  
Future Research

Hepatitis C virus (HCV) still represents a major public health threat, with a dramatic burden from both epidemiological and clinical points of view. New generation of direct-acting antiviral agents (DAAs) has been recently introduced in clinical practice promising to cure HCV and to overcome the issues related to the interferon-based therapies. However, the emergence of drug resistance and the suboptimal activity of DAAs therapies against diverse HCV genotypes have been observed, determining treatment failure and hampering an effective control of HCV spread worldwide. Moreover, these treatments remain poorly accessible, particularly in low-income countries. Finally, effective screening strategy is crucial to early identifying and treating all HCV chronically infected patients. For all these reasons, even though new drugs may contribute to impacting HCV spread worldwide a preventive HCV vaccine remains a cornerstone in the road to significantly reduce the HCV spread globally, with the ultimate goal of its eradication. Advances in molecular vaccinology, together with a strong financial, political, and societal support, will enable reaching this fundamental success in the coming years. In this comprehensive review, the state of the art about these major topics in the fight against HCV and the future of research in these fields are discussed.

scholarly journals A Lay-User Assessment of Hepatitis C Virus Self-Testing Device Usability and Interpretation in Johannesburg, South Africa

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 463
Author(s):  
Mohammed Majam ◽  
Alex Fischer ◽  
Elena Ivanova Reipold ◽  
Naleni Rhagnath ◽  
Vanessa Msolomba ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Low Income ◽  
Low Income Countries ◽  
Sample Collection ◽  
Cross Sectional ◽  
Negative Results ◽  
First Response ◽  
Self Testing ◽  
Instructions For Use

Only 20% of people with hepatitis C virus (HCV) know their status. In low-income countries diagnosis is under 10%. Self-testing for HCV antibodies (HCVST) could expand the coverage of HCV testing services. Currently, there are no stringent regulatory authority (SRA) approved HCVSTs, therefore lay-user usability of three prototype kits was assessed. This was a cross-sectional observational study conducted with 171 (CareStart n = 60, Bioline n = 52, First Response n = 59) participants. Participants were given one of the three HCVST kits with only instructions for use (IFU) and asked to perform the test in front of a professional trained in rapid diagnostic tests (RDT). Usability indices were calculated based on the correctness of performing each step of the product-specific process followed by contrived results interpretation and a post-test interview. The usability index was 93.9% for CareStart, 90.7% for Bioline and 94.9% for First Response. Most errors were on incorrect handwashing, sample collection and transfer to the test device. An average of 93.1% of contrived results were correctly interpreted, with most errors related to interpreting invalid results. Most participants (n = 167) stated they would visit a clinic after a positive result. With negative results, nearly half (28/60 (46.7%)) stated they should condomize, while just over two-thirds of participants that used Bioline (35/52 (67.3%)) and First Response (38/59 (64.4%)) said they should re-test. Most participants (n = 162) found the devices easy to use. Participants liked that self-testing was fast, private and convenient, however there were some confusion with IFU steps and pictures, finger-pricking with the lancet, collecting blood after the finger-prick, and transferring the sample/buffer. Prototype HCVST kits exhibit high usability and result interpretation by lay-users, and should be considered for SRA approval.

scholarly journals High Prevalence of Hepatitis C Virus Infection in Primitive Tribes of Eastern India and Associated Sociobehavioral Risks for Transmission: A Retrospective Analysis

Health Equity ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. 567-572 ◽  
Author(s):  
Shantanu Kumar Kar ◽  
Jyotsnamayee Sabat ◽  
Lal M. Ho ◽  
Rasmi Arora ◽  
Bhagirathi Dwibedi
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Retrospective Analysis ◽  
Hepatitis C Virus Infection ◽  
Eastern India ◽  
High Prevalence

Prospective study of hepatitis C virus infection in hemodialysis patients by monthly analysis of HCV RNA and antibodies

2003 ◽  
Vol 49 (8) ◽  
pp. 503-507 ◽  
Author(s):  
Regina Moreira ◽  
João Renato Rebello Pinho ◽  
Jorge Fares ◽  
Isabel Takano Oba ◽  
Maria Regina Cardoso ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hemodialysis Patients ◽  
Hcv Infection ◽  
Hcv Rna ◽  
Hepatitis C Virus Infection ◽  
Serum Samples ◽  
Hcv Genotypes ◽  
High Prevalence ◽  
Time Required

The aims of this study were to (i) evaluate the prevalence and the incidence of hepatitis C virus (HCV) infection in hemodialysis patients in two different centers in São Paulo (Brazil), (ii) determine the time required to detect HCV infection among these patients by serology or PCR, (iii) establish the importance of alanine aminotransferase determination as a marker of HCV infection, and (iv) identify the HCV genotypes in this population. Serum samples were collected monthly for 1 year from 281 patients admitted to hospital for hemodialysis. Out of 281 patients, 41 patients (14.6%) were HCV positive; six patients seroconverted during this study (incidence = 3.1/1000 person-month). In 1.8% (5/281) of cases, RNA was detected before the appearance of antibodies (up to 5 months), and in 1.1% (3/281) of cases, RNA was the unique marker of HCV infection. The genotypes found were 1a, 1b, 3a, and 4a. The presence of genotype 4a is noteworthy, since it is a rare genotype in Brazil. These data pointed out the high prevalence and incidence of HCV infection at hemodialysis centers in Brazil and showed that routine PCR is fundamental for improving the detection of HCV carriers among patients undergoing hemodialysis.Key words: HCV genotypes, hemodialysis, hepatitis C, PCR, prevalence, incidence.

High Prevalence of Hepatitis C Virus Infection in Patients with Rheumatoid Arthritis

1996 ◽  
Vol 2 (4) ◽  
pp. 233 ◽  
Author(s):  
Emilio DʼAmico ◽  
Carlo Palazzi ◽  
Vincenzina Fratelli ◽  
Luigi Di Matteo ◽  
Gabriele Di Girolamo ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis C Virus Infection ◽  
High Prevalence

scholarly journals Hepatitis C and the absence of genomic data in low-income countries: a barrier on the road to elimination?

2017 ◽  
Vol 2 (10) ◽  
pp. 700-701 ◽  
Author(s):  
Marc Niebel ◽  
Joshua B Singer ◽  
Sema Nickbakhsh ◽  
Robert J Gifford ◽  
Emma C Thomson
Keyword(s):  
Hepatitis C ◽  
Low Income ◽  
Genomic Data ◽  
Low Income Countries ◽  
The Road ◽  
On The Road
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