scholarly journals Cancer Therapy: Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model (Adv. Funct. Mater. 28/2018)

2018 ◽  
Vol 28 (28) ◽  
pp. 1870196 ◽  
Author(s):  
Hai-Jun Liu ◽  
Xin Luan ◽  
Hai-Yi Feng ◽  
Xiao Dong ◽  
Si-Cong Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Therapy ◽  
Delivery System ◽  
Combination Treatment ◽  
Cancer Model ◽  
Microrna Delivery

scholarly journals IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Fuqing Hu ◽  
Da Song ◽  
Yumeng Yan ◽  
Changsheng Huang ◽  
Chentao Shen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
Complex Formation ◽  
Combination Treatment ◽  
Molecular Mechanisms ◽  
Chemotherapy Resistance ◽  
Predictive Marker ◽  
Pharmacological Agents ◽  
Potential Strategy

AbstractExtracellular cytokines are enriched in the tumor microenvironment and regulate various important properties of cancers, including autophagy. However, the precise molecular mechanisms underlying the link between autophagy and extracellular cytokines remain to be elucidated. In the present study, we demonstrate that IL-6 activates autophagy through the IL-6/JAK2/BECN1 pathway and promotes chemotherapy resistance in colorectal cancer (CRC). Mechanistically, IL-6 triggers the interaction between JAK2 and BECN1, where JAK2 phosphorylates BECN1 at Y333. We demonstrate that BECN1 Y333 phosphorylation is crucial for BECN1 activation and IL-6-induced autophagy by regulating PI3KC3 complex formation. Furthermore, we investigate BECN1 Y333 phosphorylation as a predictive marker for poor CRC prognosis and chemotherapy resistance. Combination treatment with autophagy inhibitors or pharmacological agents targeting the IL-6/JAK2/BECN1 signaling pathway may represent a potential strategy for CRC cancer therapy.

scholarly journals Genetic engineering of a probiotic-based drug delivery system for colorectal cancer therapy

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Byung Chull An ◽  
Yongku Ryu ◽  
Oksik Choi ◽  
Sunwoong Hong ◽  
Jin Young Heo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Genetic Engineering ◽  
Drug Delivery System ◽  
Delivery System

Saponin loaded montmorillonite-human serum albumin nanocomposites as drug delivery system in colorectal cancer therapy

2018 ◽  
Vol 166 ◽  
pp. 214-222 ◽  
Author(s):  
Oznur Akbal ◽  
Tayfun Vural ◽  
Soheil Malekghasemi ◽  
Betül Bozdoğan ◽  
Emir Baki Denkbaş
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Drug Delivery System ◽  
Delivery System
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