scholarly journals Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy

2014 ◽  
Vol 3 (10) ◽  
pp. 1629-1637 ◽  
Author(s):  
Jianliang Shen ◽  
Han-Cheon Kim ◽  
Chaofeng Mu ◽  
Emanuela Gentile ◽  
Junhua Mai ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Gold Nanorods ◽  
Photothermal Therapy

Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing

Biomaterials ◽  
2016 ◽  
Vol 78 ◽  
pp. 27-39 ◽  
Author(s):  
Bei-Ke Wang ◽  
Xue-Feng Yu ◽  
Jia-Hong Wang ◽  
Zhi-Bin Li ◽  
Peng-Hui Li ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Gold Nanorods ◽  
Photothermal Therapy

Human Induced Pluripotent Stem Cells for Tumor Targeted Delivery of Gold Nanorods and Enhanced Photothermal Therapy

ACS Nano ◽  
2016 ◽  
Vol 10 (2) ◽  
pp. 2375-2385 ◽  
Author(s):  
Yanlei Liu ◽  
Meng Yang ◽  
Jingpu Zhang ◽  
Xiao Zhi ◽  
Chao Li ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Gold Nanorods ◽  
Pluripotent Stem Cells ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Induced Pluripotent

Aptamer and RVG functionalized gold nanorods for targeted photothermal therapy of neurotropic virus infection in the mouse brain

2021 ◽  
Vol 411 ◽  
pp. 128557
Author(s):  
Meishen Ren ◽  
Jiaojiao Zhou ◽  
Zhiyong Song ◽  
Hong Mei ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Neurotropic Virus

Gold nanorods conjugated with biocompatible zwitterionic polypeptide for combined chemo-photothermal therapy of cervical cancer

2021 ◽  
pp. 112014
Author(s):  
Shuang-hui Huang ◽  
Si Peng ◽  
Qiu-yue Wang ◽  
Qiu-hui Hu ◽  
Run-qin Zhang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Gold Nanorods ◽  
Photothermal Therapy

Pillar[5]arene‐Modified Gold Nanorods as Nanocarriers for Multi‐Modal Imaging‐Guided Synergistic Photodynamic‐Photothermal Therapy

2021 ◽  
pp. 2009924
Author(s):  
Nan Song ◽  
Zhijun Zhang ◽  
Peiying Liu ◽  
Dihua Dai ◽  
Chao Chen ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy

scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Treatment Outcome ◽  
Gene Silencing ◽  
Large Volume ◽  
Photothermal Therapy ◽  
Tumor Model ◽  
Vascular Wall ◽  
Tumor Treatment ◽  
Physical Methods ◽  
Vascular Disruption ◽  
Tumor Neovascularization

Customized nanomedicines can be used in a variety of ways, including angiogenesis suppression, vascular disruption, and vascular infarction. In the angiogenesis suppression approach, VEGF, VEGFR, mTOR, EGFR, bFGF, ROS, and other components have become promising therapeutic targets. The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies. In the vascular disruption approach, VDAs supplied by nanomaterials were bonded with the bonding sites of CA4, COL, PTX, and other medications on microtubules to promote rapid disintegration of tumor vascular wall cells. Combining many medicines increased the tumor treatment outcome even more. For example, disruption of tumor blood arteries caused by nanoparticle-mediated physical methods combined with chemotherapy resulted in effective treatment in a large volume tumor model. The vascular infarction methodology uses a variety of carriers, including nanoparticles, DNA nanorobots, platelet membranes, and others, to carry thrombin, tTF, and other drugs to generate local thrombosis and provide safe and effective tumor treatment.

scholarly journals A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 880 ◽  
Author(s):  
Yanhua Yao ◽  
Nannan Zhang ◽  
Xiao Liu ◽  
Qiaofeng Dai ◽  
Haiying Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Melanoma ◽  
Gold Nanorods ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Treatment Time ◽  
High Energy ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
A375 Cells

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.

Magnetic Supramolecular Nanofibers of Gold Nanorods for Photothermal Therapy

2018 ◽  
Vol 2 (4) ◽  
pp. 1800137 ◽  
Author(s):  
Qilin Yu ◽  
Ying‐Ming Zhang ◽  
Yao‐Hua Liu ◽  
Yu Liu
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy
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