Bioactive Decellularized Extracellular Matrix Derived from 3D Stem Cell Spheroids under Macromolecular Crowding Serves as a Scaffold for Tissue Engineering

2021 ◽  
pp. 2100024
Author(s):  
Cheng‐En Chiang ◽  
Yi‐Qiao Fang ◽  
Chao‐Ting Ho ◽  
Marisa Assunção ◽  
Sheng‐Ju Lin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Macromolecular Crowding ◽  
Cell Spheroids ◽  
Decellularized Extracellular Matrix

scholarly journals Cues from human atrial extracellular matrix enrich the atrial differentiation of human induced pluripotent stem cell-derived cardiomyocytes

2021 ◽  
Author(s):  
Fernanda C. P. Mesquita ◽  
Jacquelynn Morrissey ◽  
Po-Feng Lee ◽  
Gustavo Monnerat ◽  
Yutao Xi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Cardiac Differentiation ◽  
Twofold Increase ◽  
Decellularized Extracellular Matrix ◽  
Induced Pluripotent

Decellularized extracellular matrix (dECM) from human atria preserves key native components that directed the cardiac differentiation of hiPSCs to an atrial-like phenotype, yielding a twofold increase of functional atrial-like cells.

Genipin-crosslinked adipose stem cell derived extracellular matrix-nano graphene oxide composite sponge for skin tissue engineering

2018 ◽  
Vol 6 (6) ◽  
pp. 979-990 ◽  
Author(s):  
Batzaya Nyambat ◽  
Chih-Hwa Chen ◽  
Pei-Chun Wong ◽  
Chih-Wei Chiang ◽  
Mantosh Kumar Satapathy ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Graphene Oxide ◽  
Stem Cell ◽  
Adipose Stem Cell ◽  
High Mechanical Property ◽  
Skin Tissue Engineering ◽  
Oxide Composite ◽  
Nano Graphene

3D Bioscaffold with relative high mechanical property was developed using rabbit ADSCs.

Application of marrow mesenchymal stem cell-derived extracellular matrix in peripheral nerve tissue engineering

2016 ◽  
Vol 11 (8) ◽  
pp. 2250-2260 ◽  
Author(s):  
Yun Gu ◽  
Zhenmeiyu Li ◽  
Jing Huang ◽  
Hongkui Wang ◽  
Xiaosong Gu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Peripheral Nerve ◽  
Nerve Tissue ◽  
Nerve Tissue Engineering

scholarly journals Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial

2021 ◽  
Author(s):  
Svenja Nellinger ◽  
Ivana Mrsic ◽  
Silke Keller ◽  
Simon Heine ◽  
Alexander Southan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Cultured Cells ◽  
Structural Characteristics ◽  
Human Adipose Tissue ◽  
Minimal Invasive ◽  
Healthcare Applications ◽  
Decellularized Extracellular Matrix

Due to its availability and minimal invasive harvesting human adipose tissue-derived extracellular matrix (dECM) is often used as a biomaterial in various tissue engineering and healthcare applications. Next to dECM, cell-derived ECM (cdECM) can be generated by and isolated from in vitro cultured cells. So far both types of ECM were investigated extensively towards their application as (bio)material in tissue engineering and healthcare. However, a systematic characterization and comparison of soft tissue dECM and cdECM is still missing. In this study, we characterized dECM from human adipose tissue, as well as cdECM from human adipose-derived stem cells (ASCs), towards their molecular composition, structural characteristics, and biological purity. The dECM was found to exhibit higher levels of collagens and lower levels of sulfated glycosaminoglycans (sGAGs) compared to cdECMs. Structural characteristics revealed an immature state of the fibrous part of cdECM samples. By the identified differences, we aim to support researchers in the selection of a suitable ECM-based biomaterial for their specific application and the interpretation of obtained results.

Stem cell spheroids incorporating fibers coated with adenosine and polydopamine as a modular building blocks for bone tissue engineering

Biomaterials ◽  
2020 ◽  
Vol 230 ◽  
pp. 119652 ◽  
Author(s):  
Taufiq Ahmad ◽  
Hayeon Byun ◽  
Jinkyu Lee ◽  
Sajeesh Kumar Madhurakat Perikamana ◽  
Young Min Shin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Building Blocks ◽  
Cell Spheroids

scholarly journals Macromolecular Crowding Directs Extracellular Matrix Organization and Mesenchymal Stem Cell Behavior

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37904 ◽  
Author(s):  
Adam S. Zeiger ◽  
Felicia C. Loe ◽  
Ran Li ◽  
Michael Raghunath ◽  
Krystyn J. Van Vliet
Keyword(s):  
Extracellular Matrix ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Macromolecular Crowding ◽  
Cell Behavior ◽  
Matrix Organization

scholarly journals Decellularized Extracellular Matrix Derived from Porcine Adipose Tissue as a Xenogeneic Biomaterial for Tissue Engineering

2012 ◽  
Vol 18 (11) ◽  
pp. 866-876 ◽  
Author(s):  
Young Chan Choi ◽  
Ji Suk Choi ◽  
Beob Soo Kim ◽  
Jae Dong Kim ◽  
Hwa In Yoon ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Decellularized Extracellular Matrix
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