Therapeutic Ultrasound Triggered Silk Fibroin Scaffold Degradation

2021 ◽  
pp. 2100048
Author(s):  
Megan K. DeBari ◽  
Xiaodan Niu ◽  
Jacqueline V. Scott ◽  
Mallory D. Griffin ◽  
Sean R. Pereira ◽  
...  
2016 ◽  
Vol 4 (17) ◽  
pp. 2903-2912 ◽  
Author(s):  
Xiufang Li ◽  
Renchuan You ◽  
Zuwei Luo ◽  
Guo Chen ◽  
Mingzhong Li

A novel silk fibroin scaffold containing micro-/nano-fibers promoted dermal regeneration by providing 3D topographic cues.


2014 ◽  
Vol 68 ◽  
pp. 158-168 ◽  
Author(s):  
Jung-Ho Kim ◽  
Faheem A. Sheikh ◽  
Hyung Woo Ju ◽  
Hyun Jung Park ◽  
Bo Mi Moon ◽  
...  

2020 ◽  
Vol 7 (4) ◽  
pp. 403-412
Author(s):  
Wei Liu ◽  
Yanfeng Sun ◽  
Xiaohui Dong ◽  
Qi Yin ◽  
Huimin Zhu ◽  
...  

Abstract The cell-derived extracellular matrix (ECM)-modified scaffolds have advantages of mimic tissue specificity and been thought to better mimic the native cellular microenvironment in vitro. ECM derived from cardiac fibroblasts (CFs) are considered as key elements that provide a natural cell growth microenvironment and change the fate of cardiomyocytes (CMs). Here, a new hybrid scaffold is designed based on silk fibroin (SF) scaffold and CFs-derived ECM. CFs were seeded on the SF scaffold for 10 days culturing and decellularized to produce CFs-derived ECM-coated SF scaffold. The results showed that the cell-derived ECM-modified silk fibroin scaffold material contained collagen, laminin, fibronectin and other ECM components with myocardial-like properties. Further to explore its effects on brown adipose stem cells (BASCs) differentiation into CMs. We found that the CF-derived ECM-coated scaffold also increased the expression of CM-specific proteins (e.g. cardiac troponin T and α-actinin) of BASCs. Notably, the β1-integrin-dependent transforming growth factor-β1 signaling pathway was also involved in the regulation of CF-derived ECM by promoting the differentiation of BASCs into CMs. Overall, these findings provide insights into the bionic manufacturing of engineered cardiac tissues (ECTs) and establish a theoretical basis for the construction of ECTs.


2010 ◽  
Vol 142 (3_suppl) ◽  
pp. S33-S35 ◽  
Author(s):  
Brett Levin ◽  
Sharon Leanne Redmond ◽  
Rangam Rajkhowa ◽  
Robert Henry Eikelboom ◽  
Robert Jeffery Marano ◽  
...  

2019 ◽  
Vol 102 ◽  
pp. 471-482 ◽  
Author(s):  
Laura Gambari ◽  
Emanuela Amore ◽  
Rosasilvia Raggio ◽  
Walter Bonani ◽  
Marli Barone ◽  
...  

2014 ◽  
Vol 29 (2) ◽  
pp. 199-208 ◽  
Author(s):  
Maryam Rahimi ◽  
Homa Mohseni-Kouchesfehani ◽  
Amir-Hassan Zarnani ◽  
Sahba Mobini ◽  
Shohreh Nikoo ◽  
...  

2009 ◽  
Vol 6 (6) ◽  
pp. 653-664 ◽  
Author(s):  
Brett Levin ◽  
Rangam Rajkhowa ◽  
Sharon Leanne Redmond ◽  
Marcus David Atlas

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