Tissue Engineering: Engineering Silk Fibroin‐Based Nerve Conduit with Neurotrophic Factors for Proximal Protection after Peripheral Nerve Injury (Adv. Healthcare Mater. 2/2021)

Peripheral nerve injury (PNI) remains an unresolved challenge in the medicine area. With the development of biomaterial science and tissue engineering, a variety of nerve conduits were widely applied in...

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Neurotrophic Factors in Peripheral Nerve Injury and Regeneration

Neurotrophic Factors - Handbook of Experimental Pharmacology ◽

10.1007/978-3-642-59920-0_6 ◽

1999 ◽

pp. 147-173 ◽

Cited By ~ 1

Author(s):

N. M. J. Rupniak ◽

J. M. A. Laird ◽

S. Boyce ◽

R. G. Hill

Keyword(s):

Peripheral Nerve ◽

Nerve Injury ◽

Neurotrophic Factors ◽

Peripheral Nerve Injury

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Intraluminal Guiding Structure of Nerve Conduits for Peripheral Nerve Regeneration

Science of Advanced Materials ◽

10.1166/sam.2020.3720 ◽

2020 ◽

Vol 12 (1) ◽

pp. 56-65 ◽

Cited By ~ 2

Author(s):

Tianhao Yu ◽

Yingxi Xu ◽

Xingya Jia ◽

Qiang Ao

Keyword(s):

Tissue Engineering ◽

Peripheral Nerve ◽

Nerve Injury ◽

Peripheral Nerve Injury ◽

Peripheral Nerve Regeneration ◽

Clinical Practices ◽

Nerve Grafts ◽

Nerve Conduits ◽

Engineering Designs ◽

Basement Membrane Collagen

Peripheral nerve injury that can lead to disability affects millions of people worldwide annually. As the gold standard treatment of peripheral nerve injury, autologous nerve grafts are the most widely used and effective, but the clinical application of the treatment is greatly limited by many disadvantages. Tissue engineering nerve conduits gradually become promising autologous nerve grafts alternatives to promote the regeneration of injured nerves. This review places emphasis on tissue engineering designs of physical and topographic guiding structure inside nerve conduits in order to promote the migration of Schwann cells and directional regrowth of axons towards target organs. Various strategies of intraluminal guiding cues have been described and analyzed, including the incorporation with the tissue with natural basement membrane, collagen, microfilaments, intraluminal multi-channel and grooves in the inner wall. Recently, much progress has been made in the development of tissue engineering nerve conduits, but poor curative effect and deficiencies such as axon dispersion and malposition healing still remain unsolved, many crucial factors need to be considered in further research before clinical practices.

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Past, Present, and Future of Nerve Conduits in the Treatment of Peripheral Nerve Injury

BioMed Research International ◽

10.1155/2015/237507 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 70

Author(s):

Aikeremujiang Muheremu ◽

Qiang Ao

Keyword(s):

Stem Cells ◽

Clinical Practice ◽

Peripheral Nerve ◽

Schwann Cells ◽

Nerve Injury ◽

Neurotrophic Factors ◽

Peripheral Nerve Injury ◽

Functional Outcomes ◽

Nerve Conduits ◽

New Construction

With significant advances in the research and application of nerve conduits, they have been used to repair peripheral nerve injury for several decades. Nerve conduits range from biological tubes to synthetic tubes, and from nondegradable tubes to biodegradable tubes. Researchers have explored hollow tubes, tubes filled with scaffolds containing neurotrophic factors, and those seeded with Schwann cells or stem cells. The therapeutic effect of nerve conduits is improving with increasing choice of conduit material, new construction of conduits, and the inclusion of neurotrophic factors and support cells in the conduits. Improvements in functional outcomes are expected when these are optimized for use in clinical practice.

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Time‐restricted release of multiple neurotrophic factors promotes axonal regeneration and functional recovery after peripheral nerve injury

The FASEB Journal ◽

10.1096/fj.201802065rr ◽

2019 ◽

Vol 33 (7) ◽

pp. 8600-8613 ◽

Cited By ~ 6

Author(s):

Liangliang Huang ◽

Bing Xia ◽

Xiaowei Shi ◽

Jianbo Gao ◽

Yujie Yang ◽

...

Keyword(s):

Peripheral Nerve ◽

Nerve Injury ◽

Functional Recovery ◽

Neurotrophic Factors ◽

Peripheral Nerve Injury ◽

Axonal Regeneration

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Using Stem Cells to Grow Artificial Tissue for Peripheral Nerve Repair

Stem Cells International ◽

10.1155/2016/7502178 ◽

2016 ◽

Vol 2016 ◽

pp. 1-18 ◽

Cited By ~ 28

Author(s):

Kulraj Singh Bhangra ◽

Francesca Busuttil ◽

James B. Phillips ◽

Ahad A. Rahim

Keyword(s):

Tissue Engineering ◽

Stem Cells ◽

Nervous System ◽

Peripheral Nerve ◽

Nerve Injury ◽

Peripheral Nerve Injury ◽

Nerve Repair ◽

Cell Types ◽

Neural Lineage ◽

Essential Resource

Peripheral nerve injury continues to pose a clinical hurdle despite its frequency and advances in treatment. Unlike the central nervous system, neurons of the peripheral nervous system have a greater ability to regenerate. However, due to a number of confounding factors, this is often both incomplete and inadequate. The lack of supportive Schwann cells or their inability to maintain a regenerative phenotype is a major factor. Advances in nervous system tissue engineering technology have led to efforts to build Schwann cell scaffolds to overcome this and enhance the regenerative capacity of neurons following injury. Stem cells that can differentiate along a neural lineage represent an essential resource and starting material for this process. In this review, we discuss the different stem cell types that are showing promise for nervous system tissue engineering in the context of peripheral nerve injury. We also discuss some of the biological, practical, ethical, and commercial considerations in using these different stem cells for future clinical application.

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