In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

2012 ◽  
Vol 24 (41) ◽  
pp. 5586-5592 ◽  
Author(s):  
Kai Yang ◽  
Huan Xu ◽  
Liang Cheng ◽  
Chunyang Sun ◽  
Jun Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Organic Nanoparticles

Correction: In Vitro and In Vivo Near-Infrared Photothermal Therapy of Cancer Using Polypyrrole Organic Nanoparticles

2013 ◽  
Vol 25 (7) ◽  
pp. 945-945 ◽  
Author(s):  
Kai Yang ◽  
Huan Xu ◽  
Liang Cheng ◽  
Chunyang Sun ◽  
Jun Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Organic Nanoparticles

scholarly journals Injectable and Temperature-Sensitive Titanium Carbide-Loaded Hydrogel System for Photothermal Therapy of Breast Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Jun Yao ◽  
Chuanda Zhu ◽  
Tianjiao Peng ◽  
Qiang Ma ◽  
Shegan Gao
Keyword(s):  
Titanium Carbide ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Therapeutic Strategy ◽  
Near Infrared ◽  
Pluronic F127 ◽  
Temperature Sensitive ◽  
Hydrogel System

Recently, organic–inorganic hybrid materials have gained much attention as effective photothermal agents for cancer treatment. In this study, Pluronic F127 hydrogel-coated titanium carbide (Ti3C2) nanoparticles were utilized as an injectable photothermal agent. The advantages of these nanoparticles are their green synthesis and excellent photothermal efficiency. In this system, lasers were mainly used to irradiate Ti3C2 nanoparticles to produce a constant high temperature, which damaged cancer cells. The nanoparticles were found to be stable during storage at low temperatures for at least 2 weeks. The Ti3C2 nanoparticles exhibited a shuttle-shaped structure, and the hydrogels presented a loosely meshed structure. In addition, Ti3C2 nanoparticles did not affect the reversible temperature sensitivity of the gel, and the hydrogel did not affect the photothermal properties of Ti3C2 nanoparticles. The in vitro and in vivo results show that this hydrogel system can effectively inhibit tumor growth upon exposure to near-infrared irradiation with excellent biocompatibility and biosafety. The photothermal agent-embedded hydrogel is a promising photothermal therapeutic strategy for cancer treatment by enhancing the retention in vivo and elevating the local temperature in tumors.

The synergistic effect of chemo-photothermal therapies in SN-38-loaded gold-nanoshell-based colorectal cancer treatment

Nanomedicine ◽  
2021 ◽  
Author(s):  
Shu-Jyuan Yang ◽  
Hsiao-Ting Huang ◽  
Chung-Huan Huang ◽  
Jui-An Pai ◽  
Chung-Hao Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Au Nps ◽  
Tumor Mouse Model ◽  
Tumor Clearance ◽  
Tumor Growth Suppression

Aim: 7-Ethyl-10-hydroxycamptothecin (SN-38)-loaded gold nanoshells nanoparticles (HSP@Au NPs) were developed for combined chemo-photothermal therapy to treat colorectal cancer. Materials & methods: SN-38-loaded nanoparticles (HSP NPs) were prepared by the lyophilization-hydration method, and then developed into gold nanoshells. The nanoparticles were characterized and assessed for photothermal properties, cytotoxicity and hemocompatibility in vitro. In vivo anticancer activity was tested in a tumor mouse model. Results: The HSP@Au NPs (diameter 186.9 nm, zeta potential 33.4 mV) led to significant cytotoxicity in cancer cells exposed to a near-infrared laser. Moreover, the HSP@Au NP-mediated chemo-photothermal therapy displayed significant tumor growth suppression and disappearance (25% of tumor clearance rate) without adverse side effects in vivo. Conclusion: HSP@Au NPs may be promising in the treatment of colorectal cancer in the future.

Controllable Synthesis of Gold Nanorod/Conducting Polymer Core/Shell Hybrids Toward in Vitro and in Vivo near-Infrared Photothermal Therapy

2018 ◽  
Vol 10 (15) ◽  
pp. 12323-12330 ◽  
Author(s):  
Juan Wang ◽  
Chunhua Zhu ◽  
Jie Han ◽  
Na Han ◽  
Juqun Xi ◽  
...  
Keyword(s):  
Conducting Polymer ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanorod ◽  
Core Shell ◽  
Controllable Synthesis

scholarly journals Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Xunzhi Wu ◽  
Yongkuan Suo ◽  
Hui Shi ◽  
Ruiqi Liu ◽  
Fengxia Wu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Laser Excitation ◽  
Tumor Treatment ◽  
Deep Tissue ◽  
Laser Illumination ◽  
Nir Light ◽  
Cell Ablation

Abstract Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700 nm) especially NIR-IIa window (1300–1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome.

CuS–Pt(iv)–PEG–FA nanoparticles for targeted photothermal and chemotherapy

2016 ◽  
Vol 4 (35) ◽  
pp. 5938-5946 ◽  
Author(s):  
Huiting Bi ◽  
Yunlu Dai ◽  
Jiating Xu ◽  
Ruichan Lv ◽  
Fei He ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Drug Induced ◽  
Nir Light

CuS–Pt(iv) nanoparticles exhibited high in vitro and in vivo anti-tumor efficiency, which was caused by the integrated Pt drug-induced chemotherapy and CuS nanoparticle-mediated photothermal therapy (PTT) upon irradiation with near infrared (NIR) light.

scholarly journals Ultrasmall PEI-Decorated Bi2Se3 Nanodots as a Multifunctional Theranostic Nanoplatform for in vivo CT Imaging-Guided Cancer Photothermal Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Peng Zhang ◽  
Lei Wang ◽  
Xiuying Chen ◽  
Xiang Li ◽  
Qinghai Yuan
Keyword(s):  
Photothermal Therapy ◽  
Room Temperature ◽  
Near Infrared ◽  
Infrared Region ◽  
Ct Imaging ◽  
Broad Absorption ◽  
Good Biocompatibility ◽  
Imaging Performance

Bi-based nanomaterials, such as Bi2Se3, play an important part in biomedicine, such as photothermal therapy (PTT) and computed tomography (CT) imaging. Polyethylenimine (PEI)-modified ultrasmall Bi2Se3 nanodots were prepared using an ultrafast synthetic method at room temperature (25°C). Bi2Se3 nanodots exhibited superior CT imaging performance, and could be used as effective photothermal reagents owing to their broad absorption in the ultraviolet–visible–near infrared region. Under irradiation at 808 nm, PEI-Bi2Se3 nanodots exhibited excellent photothermal-conversion efficiency of up to 41.3%. Good biocompatibility and significant tumor-ablation capabilities were demonstrated in vitro and in vivo. These results revealed that PEI-Bi2Se3 nanodots are safe and a good nanotheranostic platform for CT imaging-guided PTT of cancer.

scholarly journals Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Jian-Li Chen ◽  
Han Zhang ◽  
Xue-Qin Huang ◽  
Hong-Ye Wan ◽  
Jie Li ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
A549 Cells ◽  
In Vivo Studies ◽  
Human Lung Cancer ◽  
Strong Light ◽  
Therapy Strategy

Abstract Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO2) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO2 nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm−2, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.

Galactosylated Chitosan Modified Magnetic Mesoporous Silica Nanoparticles Loaded with Nedaplatin for the Targeted Chemo-Photothermal Synergistic Therapy of Cancer

2021 ◽  
Vol 21 (9) ◽  
pp. 4553-4564
Author(s):  
Yihan Kong ◽  
Xue Li ◽  
Xiaojing Liu ◽  
Jingjing Pang ◽  
Xinling Mu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Mesoporous Silica Nanoparticles ◽  
Specific Area ◽  
Drug Uptake ◽  
Galactosylated Chitosan ◽  
Magnetic Mesoporous Silica

The use of chemotherapy combined with photothermal therapy (PTT) is getting a focus topic for cancer treatment. Duing this research, the double targeting drug delivery system of nedaplatin (NDP)–carboxyl-functionalized magnetic mesoporous silica (MMSN-COOH)–galactosylated chitosan (GC) nanoparticles (NPs) was constructed. Because MMSNs have special physical properties, it can target to the specific area. In addition, it’s able to convert absorbed near-infrared (NIR) light into heat energy for photothermal therapy (PTT). Furthermore, the thermal energy generated by MMSNs under NIR lasers can accelerate the release of drug from preparations. Moreover, GC modified MMSNs-COOH as a carrier can increase the drug uptake of cancer cells that highly express galectins in vitro, resulting in cancer cell apoptosis, and thus increasing the targeting of cancerous tissue in vivo. The experimental consequences in vitro and in vivo revealed that the NDP@MMSNCOOH-GC NPs combined with PTT could avoid systemic toxicity and improve biosecurity while having good anticancer effect.

Second Near-Infrared Photoactivatable Biocompatible Polymer Nanoparticles for Effective in Vitro and in Vivo Cancer Theranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Fei Wang ◽  
Xiaoju Men ◽  
Haobin Chen ◽  
Feixue Mi ◽  
Mengze Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Tissue Penetration ◽  
Biocompatible Polymer ◽  
Cancer Theranostics ◽  
Maximum Permissible Exposure

Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) has drawn considerable attention due to the deeper tissue penetration and higher maximum permissible exposure. However, current phototheranostic agents are greatly restricted to the...

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