Printed Iontophoretic‐Integrated Wearable Microfluidic Sweat‐Sensing Patch for On‐Demand Point‐Of‐Care Sweat Analysis

2021 ◽  
Vol 6 (4) ◽  
pp. 2000910
Author(s):  
Brince Paul ◽  
Silvia Demuru ◽  
Céline Lafaye ◽  
Mathieu Saubade ◽  
Danick Briand
Keyword(s):  

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 588 ◽  
Author(s):  
Kai Sachsenheimer ◽  
Christiane Richter ◽  
Dorothea Helmer ◽  
Frederik Kotz ◽  
Bastian Ernst Rapp

Microcontrollers have a low energy consumption and are convenient tools for the operation and readout of small lab-on-a-chip devices. The operation of microcontrollers for data collection and analysis is key for measurements and statistics in field experiments. However, for portable lab-on-a-chip or point-of-care systems in low-resource settings, the availability of energy sources is a bottleneck. Here, we present a simple, nontoxic aluminum/air redox battery with a 3D-printed housing for on-demand operation of a sensor using a microcontroller for data collection. The battery is stored in a dry state and can be manufactured conveniently using off-the-shelf components and a simple 3D printer. It can be quickly assembled and operates a microcontroller for at least one hour in continuous operation mode. We demonstrate its performance by collecting data from a capacitive sensor capable of determining the conductivity of liquid samples. Such sensors can be used for, e.g., determining the water quality or phase formation in liquid mixtures. The sensor performance in determining different conductivities of nonconductive and conductive liquids in droplets is demonstrated.



Author(s):  
Shimin Yu ◽  
Zhongqi Sun ◽  
Zhanxiang Zhang ◽  
Haoran Sun ◽  
Lina Liu ◽  
...  

With the development of designed materials and structures, a wide array of micro/nanomachines with versatile functionalities are employed for specific sensing applications. Here, we demonstrated a magnetic propelled microdimer-based point-of-care testing system, which can be used to provide the real-time data of plasma glucose and lipids relying on the motion feedback of mechanical properties. On-demand and programmable speed and direction of the microdimers can be achieved with the judicious adjustment of the external magnetic field, while their velocity and instantaneous postures provide estimation of glucose, cholesterol, and triglycerides concentrations with high temporal accuracy. Numerical simulations reveal the relationship between motility performance and surrounding liquid properties. Such technology presents a point-of-care testing (POCT) approach to adapt to biofluid measurement, which advances the development of microrobotic system in biomedical fields.





VASA ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 429-438 ◽  
Author(s):  
Berent ◽  
Sinzinger

Based upon various platelet function tests and the fact that patients experience vascular events despite taking acetylsalicylic acid (ASA or aspirin), it has been suggested that patients may become resistant to the action of this pharmacological compound. However, the term “aspirin resistance” was created almost two decades ago but is still not defined. Platelet function tests are not standardized, providing conflicting information and cut-off values are arbitrarily set. Intertest comparison reveals low agreement. Even point of care tests have been introduced before appropriate validation. Inflammation may activate platelets, co-medication(s) may interfere significantly with aspirin action on platelets. Platelet function and Cox-inhibition are only some of the effects of aspirin on haemostatic regulation. One single test is not reliable to identify an altered response. Therefore, it may be more appropriate to speak about “treatment failure” to aspirin therapy than using the term “aspirin resistance”. There is no evidence based justification from either the laboratory or the clinical point of view for platelet function testing in patients taking aspirin as well as from an economic standpoint. Until evidence based data from controlled studies will be available the term “aspirin resistance” should not be further used. A more robust monitoring of factors resulting in cardiovascular events such as inflammation is recommended.



2008 ◽  
Author(s):  
Jamie Chamberlin
Keyword(s):  


Author(s):  
Matthew Chalmers
Keyword(s):  


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