scholarly journals Long‐term effects of an oral elemental nutritional supplement on post‐gastrectomy body weight loss in gastric cancer patients (KSES002)

2019 ◽  
Vol 3 (6) ◽  
pp. 648-656 ◽  
Author(s):  
Yutaka Kimura ◽  
Kazuhiro Nishikawa ◽  
Kentaro Kishi ◽  
Kentaro Inoue ◽  
Jin Matsuyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Weight Loss ◽  
Body Weight ◽  
Cancer Patients ◽  
Body Weight Loss ◽  
Nutritional Supplement ◽  
Long Term Effects ◽  
Gastric Cancer Patients

Long-term effects of an oral elemental nutritional supplement on post-gastrectomy body weight loss in gastric cancer patients.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 94-94
Author(s):  
Kazuhiro Nishikawa ◽  
Yutaka Kimura ◽  
Kentaro Kishi ◽  
Kentaro Inoue ◽  
Jin Matsuyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Weight Loss ◽  
Body Weight ◽  
Cancer Patients ◽  
Total Gastrectomy ◽  
Body Weight Loss ◽  
Nutritional Intervention ◽  
Control Group ◽  
Gastric Cancer Patients

94 Background: Postoperative weight loss could have a negative effect on quality of life and prognosis of gastric cancer patients. We have already shown that daily nutritional intervention with an oral elemental diet (ED) attenuated the short-term postoperative percentage of body weight loss (% BWL) in post-gastrectomy patients, especially in underwent total gastrectomy (TG). This study was conducted to evaluate the postoperative long-term BWL of nutritional intervention. Methods: This study was conducted in a cohort of consecutive patients which were randomly allocated to receive the control or ED diet in the original trial. Control group received the regular diet alone after gastrectomy, while ED group received 300 kcal of ED plus their regular diet for 6–8 weeks. The primary endpoint was the % BWL from the presurgical bodyweight to that at 1 year after surgery by surgical type. Secondary endpoints were changes in nutrition-related blood parameters. Results: One hundred six of registered patients in the original trial were eligible for efficacy analyses. There was not significant difference in the % BWL between the two groups (9.13 ± 7.72 % vs. 7.09 ± 7.49 %, respectively; p = 0.171). The % BWL at one year after surgery was significantly lower in ED group than in control group among patients who underwent TG (n = 19 and 17, respectively; 9.66 ± 5.98% vs. 15.11 ± 6.78%, respectively; p = 0.015), but not in patients who underwent distal gastrectomy (DG) (n = 38 and 32, respectively; 5.81 ± 7.91% vs. 5.96 ± 6.20%, respectively; p = 0.933). A multivariate analysis revealed that only type of gastrectomy was independently associated with % BWL at 1 year after surgery. And in total gastrectomy, ED administration was independently associated with % BWL. Total lymphocyte count in ED group increased more than that in control group at 1 year after surgery. Conclusions: Nutritional intervention with ED at 300 kcal per day for 6–8 weeks reduced body weight loss at 1 year as well as 6-8 weeks after surgery in patients who underwent total gastrectomy. Clinical trial information: 000023455.

scholarly journals Analysis of factors contributing to postoperative body weight change in patients with gastric cancer: based on generalized estimation equation

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9390
Author(s):  
Qiuju Tian ◽  
Liyuan Qin ◽  
Weiyi Zhu ◽  
Shaojie Xiong ◽  
Beiwen Wu
Keyword(s):  
Gastric Cancer ◽  
Weight Loss ◽  
Body Weight ◽  
Cancer Patients ◽  
Total Gastrectomy ◽  
Weight Change ◽  
Body Weight Loss ◽  
Body Weight Change ◽  
Generalized Estimation Equation ◽  
Gastric Cancer Patients

Aims The study aimed to explore factors contributing to body weight change over time in gastric cancer patients after gastrectomy, in order to find risk factors to implement nutritional intervention beforehand. Methods A cohort of gastric cancer patients who were treated with gastrectomy from January to March 2019 at a university affiliated hospital in Shanghai were consecutively identified in this study. Demographics, disease related information, nutrition knowledge, attitude, and practice score were collected before gastrectomy. In addition, body weight before surgery (T0), body weight at one month (T1), two months (T2), and three months (T3) after gastrectomy were recorded. Generalized estimation equation was used to describe body weight change and analyze factors contributing to body weight change after surgery. Results There were 49 patients recruited in the study. Patient body weight decreased by 9.2% at T1 (Wald χ = 271.173, P <0.001), 11.0% at T2 (Wald χ2 = 277.267, P <0.001), and 11.4% at T3 compared to baseline at T0 (Wald χ = 284.076, P <0.001). The results of GEE for multivariable analysis showed that surgery type (Wald χ = 6.027, P = 0.014) and preoperative BMI (Wald χ = 12.662, P = 0.005) were contributing factors of body weight change. Compared with distal gastrectomy patients, total gastrectomy patients experienced greater body weight loss (β = 2.8%, P = 0.014). Compared with patients with BMI&λτ; 18.5 kg/m2, patients with BMI ≥ 25 kg/m2experienced greater body weight loss (β = 4.5% P = 0.026). Conclusion Gastric cancer patients experienced significant weight loss during 3 months after gastrectomy. Total gastrectomy and BMI ≥ 25 kg/m2were risk factors to postoperative body weight loss for GC patients. The results suggested hinted that clinician should pay attention to postoperative nutrition status of patient undergoing total gastrectomy and obesity patients.

The role of nutritional assessment for predicting Radiotherapy-induced adverse events in patients with gastric cancer

2021 ◽  
Author(s):  
Wenjie Sun ◽  
Guichao Li ◽  
Jing Zhang ◽  
Ji Zhu ◽  
Zhen Zhang
Keyword(s):  
Gastric Cancer ◽  
Body Weight ◽  
Adverse Events ◽  
Cancer Patients ◽  
Body Weight Loss ◽  
Nutritional Factors ◽  
Nrs 2002 ◽  
Grade 3 ◽  
Gastric Cancer Patients

Objectives: The aim of this study was to investigate the role of nutritional factors in predicting radiotherapy-associated toxicities for gastric cancer patients. Methods: A total of 285 gastric cancer patients who underwent radiotherapy in our hospital between 2010 and 2017 were included in this retrospective study. Nutritional status assessment included body weight loss (BWL), body mass index (BMI), serum albumin, nutrition risk screening 2002(NRS-2002), patient-generated subjective global assessment(PG-SGA) and nutritional risk index (NRI). Results: Of all patients, 19.6% were underweight (BMI <18.5 kg/m2), 25.6% were hypoalbuminemia (<35 g l−1) and 48.8% lost ≥10% of body weight in the 6 month interval before radiotherapy(BWL). Meanwhile, 73.3%, 78.6 and 47.2% of the patients were diagnosed as malnutrition based on NRS-2002, PG-SGA and NRI, respectively. Hematological adverse events were present in 91.2% (≥Grade 1) and 20.4% (≥Grade 3) of the patients. Non-hematological adverse events occurred in 89.8% (≥Grade1) and 14.4% (≥Grade 3) of the patients. Multivariate analyses indicated that only hypoalbuminemia(<35 g l−1) was independent predictor for Grade 3/4 hematological and non-hematological adverse events. Meanwhile, higher BWL(≥10%) was also independent predictor for Grade 3/4 non-hematological adverse events. NRS-2002, PG-SGA and NRI score were not associated with treatment-induced adverse events. Conclusions: Body weight loss and serum albumin are useful factors for predicting severe adverse events in gastric cancer patients who undergo radiotherapy. Advances in knowledge: The use of nutritional factors in predicting severe adverse events enables implementation of individualized treatment strategies for early and intensive nutritional interventions in high-risk patients.

scholarly journals Prognostic Roles of Perioperative Body Mass Index and Weight Loss in the Long-Term Survival of Gastric Cancer Patients

2018 ◽  
Vol 27 (8) ◽  
pp. 955-962 ◽  
Author(s):  
Young Suk Park ◽  
Do Joong Park ◽  
Yoontaek Lee ◽  
Ki Bum Park ◽  
Sa-Hong Min ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Body Mass Index ◽  
Weight Loss ◽  
Cancer Patients ◽  
Body Mass ◽  
Term Survival ◽  
Long Term Survival ◽  
Gastric Cancer Patients

scholarly journals Lifestyle factors and long-term survival of gastric cancer patients: a large bidirectional cohort study from China.

2019 ◽  
Author(s):  
Lulu Zhao ◽  
Huang Huang ◽  
Tongbo Wang ◽  
Hong Zhou ◽  
Fuhai Ma ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Weight Loss ◽  
Cancer Patients ◽  
Lifestyle Factors ◽  
Cox Proportional Hazards ◽  
Smoking History ◽  
Cancer Center ◽  
Term Survival ◽  
Gastric Cancer Patients

Abstract Background: Lifestyle factors such as body mass index (BMI), alcohol drinking, and cigarette smoking, are likely to profoundly impact the prognosis of gastric cancer, but evidence has been inconsistent. Methods: Patients with gastric cancer were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) 1998-2018. Survival analysis performed via Kaplan-Meier estimates and Cox proportional hazards models. Results: In this study, we reviewed 18 441 cases of gastric cancer patients. Individuals who were overweight or obese was associated with positive smoking and drinking history (P=0.002 and P<0.001, respectively). Current smokers are more likely to be current alcohol drinkers (61.3% vs.10.1% vs. 43.2% for current, never, and former smokers, respectively, P<0.001). Multivariable results indicated that BMI at diagnosis had no significant effect on prognosis. In gastrectomy patients, factors independently associated with poor survival include older age (HR=1.20, 95% CI: 1.05-1.38, P=0.001), any weight loss (P<0.001), smoking history more than 30 years (HR=1.14, 95% CI: 1.04-1.24, P=0.004), and increasing pTNM stage (P<0.001). Conclusion: In conclusion, this study of gastric cancer patients has examined the association of lifestyle factors above with long-term prognosis. Among the patients overall, weight loss (both 0-10% and >10% groups), but not BMI values at diagnosis, was related to survival results. For other factors, smoking history of more than 30 years conferred a worse prognosis for only gastrectomy patients. Extensive efforts are needed to elucidate mechanisms targeting the complex effects of lifestyles factors.

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