Differences in testis injury and repair after vitamin A-deficiency, vitamin E-deficiency, and inanition

1933 ◽  
Vol 52 (2) ◽  
pp. 153-239 ◽  
Author(s):  
Karl E. Mason
2010 ◽  
Vol 80 (6) ◽  
pp. 355-368 ◽  
Author(s):  
Francis A. Obuseh ◽  
Pauline E. Jolly ◽  
Yi Jiang ◽  
Faisal M.B. Shuaib ◽  
John Waterbor ◽  
...  

Background: Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. Objective: To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians. Methods: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. Results: Multivariable analysis showed that participants with high AF-ALB (>= 0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR) = 2.61; CI = 1.03 - 6.58; p = 0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR = 2.4; CI = 0.96 - 6.05; p = 0.06). Conversely, those with higher AFM1 values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR = 0.31; CI = 0.09 - 1.02; p = 0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR = 0.31; CI = 0.10 - 0.97; p = 0.04). Participants with high AF-ALB or high AFM1 (>= 437.95 pg/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR = 5.88; CI = 1.71 - 20.14; p = 0.005) and (OR = 5.84; CI = 1.15 - 29.54; p = 0.03) respectively. Conclusions: These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies.


Author(s):  
Zhongqi Wan ◽  
Li Wang ◽  
Yinyang Xu ◽  
Yuanyuan Wang ◽  
Tianyou Zhang ◽  
...  

Background: College students may have risk of fat-soluble vitamins deficiencies due to unhealthy dietary habits, especially for vitamin A and E. They are important members in the human antioxidant network, deficiencies of these vitamins may increase risk of many critical diseases. Objective: The current study was undertaken to determine the status of vitamin A and E in college students. Methods: Healthy college students were recruited, and fasting blood samples of them were collected and used for determining serum levels of retinol and α-tocopherol by the HPLC method. Results: We found that there was no vitamin A deficiency in college students. However, vitamin E deficiency existed in 34.5% of college students, especially in males. All the students had no vitamin E adequacy. In addition, our findings showed that BMI was inversely associated with serum α-tocopherol, but not serum retinol. Conclusion: These results suggest that vitamin E deficiency in college students should be given more attention, and it is necessary to consider using vitamin E supplements.


2020 ◽  
Author(s):  
Xiaoyan Wang ◽  
Chunhua Jin ◽  
Jiaxin Wang ◽  
Jianhong Wang ◽  
Lili Zhang ◽  
...  

Abstract Objective To test the association between serum vitamin A and vitamin E and the prevalence of recurrent respiratory tract infections (RRTIs) of children and adolescents. Method A total amount of 5780 children and adolescents aged 2 to 17 were involved, who were classified into:A) Control group ;B) Diagnosed as RRTI with RTI symptoms; C) With RRTI but currently no RTI symptoms being noticed, and D) Not RRTI but showing respiratory disease symptoms. The correlation between serum vitamin A/E level and the presence of RRTIs were analyzed. Results Comparing with the prevalence of RRTI in children with normal vitamin A level, the Odds Ratio(OR) of vitamin A deficiency for RRTIs with symptoms was 8.32 (95%CI: 6.15 ~ 11.27), while the OR of marginal vitamin A deficiency was 1.30 (95%CI: 1.10 ~ 1.55). The OR of vitamin A deficiency or marginal vitamin A deficiency for asymptomatic RRTIs were 1.52 (95%CI: 1.00 ~ 2.32) and 1.30 (95%CI: 1.10 ~ 1.55) respectively, while the OR of vitamin A deficiency or marginal vitamin A deficiency for other respiratory diseases were 7.09 (95%CI: 5.37 ~ 9.37) and 1.60 (95%CI: 1.38 ~ 1.86). Whereas, the OR of vitamin E deficiency or marginal vitamin E deficiency for RRTIs or normal respiratory infections were showed without statistical significance. Conclusion The low level of vitamin A in serum is a risk factor for children and adolescents getting RRTIs or RTIs, indicating a possibly regulatory role of vitamin A in the respiratory diseases. In comparison, the vitamin E deficiency seems to have a weaker but still positive effect on the RRTIs or RTI


1962 ◽  
Vol 40 (10) ◽  
pp. 1347-1352 ◽  
Author(s):  
W. E. J. Phillips

Some non-saponifiable constituents of rat liver have been studied in animals differing in their nutritional status in vitamin A and E. Liver levels of ubiquinone were negatively correlated with the vitamin A status of the animal but not with the vitamin E status. The crude sterol content of the liver was not affected by variations in the intake of either vitamin, except that there was a slight but significant increase when vitamin A deficiency was pronounced.


1995 ◽  
Vol 18 (2) ◽  
pp. 119-125 ◽  
Author(s):  
Felix GRASES ◽  
Manuel ZURITA ◽  
Catalina GENESTAR ◽  
Ramon GARCIA-GONZALEZ

1962 ◽  
Vol 40 (1) ◽  
pp. 1347-1352 ◽  
Author(s):  
W. E. J. Phillips

Some non-saponifiable constituents of rat liver have been studied in animals differing in their nutritional status in vitamin A and E. Liver levels of ubiquinone were negatively correlated with the vitamin A status of the animal but not with the vitamin E status. The crude sterol content of the liver was not affected by variations in the intake of either vitamin, except that there was a slight but significant increase when vitamin A deficiency was pronounced.


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