scholarly journals The status of serum vitamin A/E and its effect on Recurrent Respiratory Tract Infections in children aged 2 to 17 years in Beijing, China, based on cross-sectional study

2020 ◽  
Author(s):  
Xiaoyan Wang ◽  
Chunhua Jin ◽  
Jiaxin Wang ◽  
Jianhong Wang ◽  
Lili Zhang ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Children And Adolescents ◽  
Respiratory Diseases ◽  
Respiratory Tract Infections ◽  
Vitamin A Deficiency ◽  
Serum Vitamin ◽  
Vitamin E Deficiency ◽  
Tract Infections ◽  
Recurrent Respiratory Tract Infections

Abstract Objective To test the association between serum vitamin A and vitamin E and the prevalence of recurrent respiratory tract infections (RRTIs) of children and adolescents. Method A total amount of 5780 children and adolescents aged 2 to 17 were involved, who were classified into:A) Control group ;B) Diagnosed as RRTI with RTI symptoms; C) With RRTI but currently no RTI symptoms being noticed, and D) Not RRTI but showing respiratory disease symptoms. The correlation between serum vitamin A/E level and the presence of RRTIs were analyzed. Results Comparing with the prevalence of RRTI in children with normal vitamin A level, the Odds Ratio(OR) of vitamin A deficiency for RRTIs with symptoms was 8.32 (95%CI: 6.15 ～ 11.27), while the OR of marginal vitamin A deficiency was 1.30 (95%CI: 1.10 ～ 1.55). The OR of vitamin A deficiency or marginal vitamin A deficiency for asymptomatic RRTIs were 1.52 (95%CI: 1.00 ～ 2.32) and 1.30 (95%CI: 1.10 ～ 1.55) respectively, while the OR of vitamin A deficiency or marginal vitamin A deficiency for other respiratory diseases were 7.09 (95%CI: 5.37 ～ 9.37) and 1.60 (95%CI: 1.38 ～ 1.86). Whereas, the OR of vitamin E deficiency or marginal vitamin E deficiency for RRTIs or normal respiratory infections were showed without statistical significance. Conclusion The low level of vitamin A in serum is a risk factor for children and adolescents getting RRTIs or RTIs, indicating a possibly regulatory role of vitamin A in the respiratory diseases. In comparison, the vitamin E deficiency seems to have a weaker but still positive effect on the RRTIs or RTI

scholarly journals Association Between Serum Vitamin A Levels and Recurrent Respiratory Tract Infections in Children

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiaoyan Wang ◽  
Xingming Li ◽  
Chunhua Jin ◽  
Xinyuan Bai ◽  
Xinran Qi ◽  
...  
Keyword(s):  
Vitamin A ◽  
Respiratory Tract ◽  
Children And Adolescents ◽  
Respiratory Tract Infections ◽  
Vitamin A Deficiency ◽  
Serum Vitamin ◽  
Cross Sectional ◽  
Subclinical Vitamin ◽  
Tract Infections ◽  
Recurrent Respiratory Tract Infections

To evaluate the association between serum vitamin A levels and the prevalence of recurrent respiratory tract infections (RRTIs) in children and adolescents and to provide evidence that would help decrease the prevalence of respiratory tract infections (RTIs) in children. This cross-sectional study included 8034 children and adolescents in Beijing aged 6 months to 17 years. RRTI and RTI symptoms were diagnosed according to the Clinical Concept and Management of Recurrent Respiratory Tract Infections in Children. Multivariate logistic regression models were used to evaluate the association between serum vitamin A levels and RRTIs after adjusting for potential confounders. Among the included children, 721 (8.97%) were diagnosed with vitamin A deficiency, whereas 3,073 (38.25%) were diagnosed with subclinical vitamin A deficiency. Only 28.8% (208/721) of children with vitamin A deficiency and 53.1% (1,631/3,073) of children with subclinical vitamin A deficiency had no RRTI and RTI symptoms, respectively. Compared with children with normal vitamin A levels, those with vitamin A deficiency and subclinical vitamin A deficiency had a greater risk for RRTIs, with an odds ratio (OR) of 6.924 [95% confidence interval (CI): 5.433–8.824] and 2.140 (95% CI: 1.825–2.510), respectively]. Vitamin A levels were also positively associated with RTI symptoms, with those having vitamin A deficiency and subclinical vitamin A deficiency showing an OR of 1.126 (95% CI: 0.773–1.640) and 1.216 (95% CI: 1.036–1.427), respectively. The present cross-sectional study found that low serum vitamin A levels were significantly associated with RRTI or RTI prevalence in children and adolescents.

scholarly journals Aflatoxin B1 albumin adducts in plasma and aflatoxin M1 in urine are associated with plasma concentrations of vitamins A and E

2010 ◽  
Vol 80 (6) ◽  
pp. 355-368 ◽  
Author(s):  
Francis A. Obuseh ◽  
Pauline E. Jolly ◽  
Yi Jiang ◽  
Faisal M.B. Shuaib ◽  
John Waterbor ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Plasma Concentrations ◽  
Multivariable Analysis ◽  
Alpha Tocopherol ◽  
Aflatoxin M1 ◽  
Vitamin E Deficiency ◽  
Cross Sectional ◽  
Virus Surface

Background: Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. Objective: To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AF-ALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians. Methods: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. Results: Multivariable analysis showed that participants with high AF-ALB (>= 0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR) = 2.61; CI = 1.03 - 6.58; p = 0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR = 2.4; CI = 0.96 - 6.05; p = 0.06). Conversely, those with higher AFM1 values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR = 0.31; CI = 0.09 - 1.02; p = 0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR = 0.31; CI = 0.10 - 0.97; p = 0.04). Participants with high AF-ALB or high AFM1 (>= 437.95 pg/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR = 5.88; CI = 1.71 - 20.14; p = 0.005) and (OR = 5.84; CI = 1.15 - 29.54; p = 0.03) respectively. Conclusions: These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies.

scholarly journals Hidden Hunger of Vitamin E Among Healthy College Students: A CrossSectional Study

2021 ◽  
Vol 21 ◽  
Author(s):  
Zhongqi Wan ◽  
Li Wang ◽  
Yinyang Xu ◽  
Yuanyuan Wang ◽  
Tianyou Zhang ◽  
...  
Keyword(s):  
College Students ◽  
Vitamin E ◽  
Vitamin A ◽  
Dietary Habits ◽  
Vitamin A Deficiency ◽  
Serum Levels ◽  
Hplc Method ◽  
Serum Retinol ◽  
Vitamin E Deficiency ◽  
The Status

Background: College students may have risk of fat-soluble vitamins deficiencies due to unhealthy dietary habits, especially for vitamin A and E. They are important members in the human antioxidant network, deficiencies of these vitamins may increase risk of many critical diseases. Objective: The current study was undertaken to determine the status of vitamin A and E in college students. Methods: Healthy college students were recruited, and fasting blood samples of them were collected and used for determining serum levels of retinol and α-tocopherol by the HPLC method. Results: We found that there was no vitamin A deficiency in college students. However, vitamin E deficiency existed in 34.5% of college students, especially in males. All the students had no vitamin E adequacy. In addition, our findings showed that BMI was inversely associated with serum α-tocopherol, but not serum retinol. Conclusion: These results suggest that vitamin E deficiency in college students should be given more attention, and it is necessary to consider using vitamin E supplements.

scholarly journals Relationship between Vitamin A Deficiency and Pneumonia Incidence of Children Under Five Years of Age in West Java

2020 ◽  
Author(s):  
Magdalena Gultom ◽  
◽  
Ririn Arminsih Wulandari ◽  
Keyword(s):  
Public Health ◽  
Vitamin A ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Vitamin A Deficiency ◽  
Lower Respiratory Tract Infections ◽  
West Java ◽  
Children Under Five ◽  
Under Five ◽  
Tract Infections

ABSTRACT Background: The leading cause of mortality in children under five years of age is acute lower respiratory tract infections, especially bronchiolitis and pneumonia. Vitamin A supplement has been studied as a potential intervention to decrease severity and prevent acute lower respiratory tract infections from subsequent episodes. This study aimed to determine the relationship between vitamin A deficiency and pneumonia incidence of children under five years of age in West Java. Subjects and Method: A cross-sectional study was conducted using the secondary data from Indonesian Demographic and Health Survey, 2017 in West Java. A sample of 594 toddlers under 5 years of age was obtained for this study. The dependent variable was pneumonia. The independent variable was vitamin A intake. The data were collected using questionnaires. The data were analyzed by chi-square. Results: As many as 38.6% children under five years of age did not get vitamin A supplement. 26.8% of children suffered pneumonia. Inadequate vitamin A intake increased the risk of pneumonia in children under five years of age (OR= 1.011, 95% CI 0.690 to 1.481; p= 1.000). Conclusion: Inadequate vitamin A intake increases the risk of pneumonia in children under five years of age, but it is not statistically significant. Keywords: vitamin A deficiency, pneumonia, prevention, under five years of age, children Correspondence: Magdalena Gultom. Masters Program in Public Health, Faculty of Public Health, Universitas Indonesia, Depok, West Java. Email: [email protected]. Mobile: +6281299714873. DOI: https://doi.org/10.26911/the7thicph.03.72

scholarly journals Excessive Vitamin A Supplementation Increased the Incidence of Acute Respiratory Tract Infections: A Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4251
Author(s):  
Yihan Zhang ◽  
Yifei Lu ◽  
Shaokang Wang ◽  
Ligang Yang ◽  
Hui Xia ◽  
...  
Keyword(s):  
Vitamin A ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Vitamin A Deficiency ◽  
Intervention Group ◽  
High Dose ◽  
Inclusion Criteria ◽  
Vitamin A Supplementation ◽  
Acute Respiratory Tract Infections ◽  
Tract Infections

(1) Background: vitamin A deficiency (VAD) is highly prevalent in children living in poor conditions. It has been suggested that vitamin A supplementation (VAS) may reduce the risk of acute respiratory tract infections (ARTI). Our study provides updates on the effects of oral VAS (alone) in children on ARTI and further explores the effect on interesting subgroups. (2) Methods: eight databases were systematically searched from their inception until 5 July 2021. The assessments of inclusion criteria, extraction of data, and data synthesis were carried out independently by two reviewers. (3) Results: a total of 26 randomized trials involving 50,944 participants fulfilled the inclusion criteria. There was no significant association of VAS with the incidence of ARTI compared with the placebo (RR 1.03, 95% CI 0.92 to 1.15). Subgroup analyses showed that VAS higher than WHO recommendations increased the incidence of ARTI by 13% (RR 1.13, 95% CI 1.07 to 1.20), and in the high-dose intervention group, the incidence rate among well-nourished children rose by 66% (RR 1.66, 95% CI 1.30 to 2.11). (4) Conclusions: no more beneficial effects were seen with VAS in children in the prevention or recovery of acute respiratory infections. Excessive VAS may increase the incidence of ARTI in children with normal nutritional status.

scholarly journals Retraction Note: Childhood iron deficiency anemia leads to recurrent respiratory tract infections and gastroenteritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jayaweera Arachchige Asela Sampath Jayaweera ◽  
Mohammed Reyes ◽  
Anpalaham Joseph
Keyword(s):  
Iron Deficiency ◽  
Respiratory Tract ◽  
Iron Deficiency Anemia ◽  
Respiratory Tract Infections ◽  
Deficiency Anemia ◽  
Link Type ◽  
Tract Infections ◽  
Recurrent Respiratory Tract Infections

Editor's Note: this Article has been retracted; the Retraction Note is available at https://doi.org/10.1038/s41598-021-90018-8.

scholarly journals Serum Vitamin E Deficiency among HIV-Infected Individuals Undergoing Antiretroviral Therapy at Ho Teaching Hospital, Ghana

Heliyon ◽  
2021 ◽  
pp. e07339
Author(s):  
Daniel Edem Kpewou ◽  
Faustina O. Mensah ◽  
Collins A. Appiah ◽  
Huseini Wiisibie Alidu ◽  
Vitus Sambo Badii
Keyword(s):  
Vitamin E ◽  
Antiretroviral Therapy ◽  
Teaching Hospital ◽  
Serum Vitamin ◽  
Vitamin E Deficiency

Prevalence of vitamin A deficiency and dietary inadequacy in Indian school-age children and adolescents

2021 ◽  
Author(s):  
Geereddy Bhanuprakash Reddy ◽  
Tattari Shalini ◽  
Santu Ghosh ◽  
Raghu Pullakhandam ◽  
Boiroju Naveen Kumar ◽  
...  
Keyword(s):  
Vitamin A ◽  
Children And Adolescents ◽  
Vitamin A Deficiency ◽  
School Age Children ◽  
School Age ◽  
Indian School

scholarly journals Acceptability of a Sublingual Drug Formulation for Respiratory Tract Infections in Children Aged 3 to 5 Years

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 294
Author(s):  
Andrzej Emeryk ◽  
Thibault Vallet ◽  
Ewelina Wawryk-Gawda ◽  
Arkadiusz Jędrzejewski ◽  
Frederic Durmont ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Drug Formulation ◽  
Reference Framework ◽  
Significant Difference ◽  
Key Factor ◽  
Treatment Safety ◽  
The Many ◽  
Tract Infections ◽  
Recurrent Respiratory Tract Infections

In pediatrics, acceptability has emerged as a key factor for compliance, and consequently for treatment safety and efficacy. Polyvalent mechanical bacterial lysate (PMBL) in 50-mg sublingual tablets is indicated in children and adults for the prophylaxis of recurrent respiratory tract infections. This medication may be prescribed in children over 3 years of age; the appropriateness of this sublingual formulation should thus be demonstrated amongst young children. Using a multivariate approach integrating the many aspects of acceptability, standardized observer reports were collected for medication intake over the course of treatment (days 1, 2, and 10) in 37 patients aged 3 to 5 years, and then analyzed in an intelligible model: the acceptability reference framework. According to this multidimensional model, 50-mg PMBL sublingual tablets were classified as “positively accepted” in children aged 3 to 5 years on all three days of evaluation. As the acceptability evaluation should be relative, we demonstrated that there was no significant difference between the acceptability of these sublingual tablets and a score reflecting the average acceptability of oral/buccal medicines in preschoolers. These results highlight that sublingual formulations could be appropriate for use in preschoolers.

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