Occupational risks of thyroid cancer: Data from the swedish cancer-environment register, 1961-1979

Abstract Context: Papillary thyroid cancer (PTC) patients <45 years old are considered to have an excellent prognosis; however, current guidelines recommend total thyroidectomy for PTC tumors >1.0 cm, regardless of age. Objective: Our objective was to examine the impact of extent of surgery on overall survival (OS) in patients <45 years old with stage I PTC of 1.1 to 4.0 cm. Design, Setting, and Patients: Adult patients <45 years of age undergoing surgery for stage I PTC were identified from the National Cancer Data Base (NCDB, 1998–2006) and the Surveillance, Epidemiology, and End Results dataset (SEER, 1988–2006). Main Outcome Measure: Multivariable modeling was used to compare OS for patients undergoing total thyroidectomy vs lobectomy. Results: In total, 29 522 patients in NCDB (3151 lobectomy, 26 371 total thyroidectomy) and 13 510 in SEER (1379 lobectomy, 12 131 total thyroidectomy) were included. Compared with patients undergoing lobectomy, patients having total thyroidectomy more often had extrathyroidal and lymph node disease. At 14 years, unadjusted OS was equivalent between total thyroidectomy and lobectomy in both databases. After adjustment, OS was similar for total thyroidectomy compared with lobectomy across all patients with tumors of 1.1 to 4.0 cm (NCDB: hazard ratio = 1.45 [confidence interval = 0.88–2.51], P = 0.19; SEER: 0.95 (0.70–1.29), P = 0.75) and when stratified by tumor size: 1.1 to 2.0 cm (NCDB: 1.12 [0.50–2.51], P = 0.78; SEER: 0.95 [0.56–1.62], P = 0.86) and 2.1 to 4.0 cm (NCDB: 1.93 [0.88–4.23], P = 0.10; SEER: 0.94 [0.60–1.49], P = 0.80). Conclusions: After adjusting for patient and clinical characteristics, total thyroidectomy compared with thyroid lobectomy was not associated with improved survival for patients <45 years of age with stage I PTC of 1.1 to 4.0 cm. Additional clinical and pathologic factors should be considered when choosing extent of resection.

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Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry

Surgery ◽

10.1016/j.surg.2010.10.016 ◽

2010 ◽

Vol 148 (6) ◽

pp. 1147-1153 ◽

Cited By ~ 155

Author(s):

John D. Cramer ◽

Pingfu Fu ◽

Karem C. Harth ◽

Seunghee Margevicius ◽

Scott M. Wilhelm

Keyword(s):

Thyroid Cancer ◽

Cancer Data ◽

Data Registry ◽

Rising Incidence ◽

End Results

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Relation between the vitamin D status and the occurrence and severity of thyroid malignancy

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.17.7.2021.244971 ◽

2021 ◽

Vol 17 (7) ◽

pp. 557-561

Author(s):

L.A. Nikitiuk ◽

Korsak Yu.

Keyword(s):

Vitamin D ◽

Thyroid Cancer ◽

Vitamin D Deficiency ◽

Large Volume ◽

Observational Studies ◽

Medical Literature ◽

Vitamin D Supplementation ◽

Vitamin D Status ◽

Vdr Gene ◽

Cancer Data

Background. In spite of large volume of data linking vitamin D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, vitamin D and thyroid is a lesser-known aspect of vitamin D in clinical practice. The association between vitamin D deficiency and thyroid cancer is controversial. Some studies have demonstrated that higher serum vitamin D levels might protect against thyroid cancer, whereas others have not, or have even indicated the opposite to to be the case. This review intends to highlight the current literature on the impact of vitamin D status on thyroid cancer. Materials and methods. References for this review were identified through searches of PubMed for articles published to from 2005 to June 2021 using the terms “thyroid cancer” and “vitamin D”. Results. A large volume of medical literature is available from observational studies linking vitamin D with thyroid cancer. Data from interventional studies documenting beneficial effects of vitamin D on thyroid autoimmunity is also available, but lesser than that from observational studies. Short-term high dose oral vitamin D supplementation reduces TPOAb titers. Certain vitamin D receptor (VDR) gene polymorphism have been linked to increased occurrence of autoimmune thyroid disorders. Vitamin D deficiency, decreased circulating calcitriol has been linked to increased thyroid cancer. Certain VDR gene polymorphisms have been linked with increased as well as decreased occurrence of thyroid cancer. Data is scant on use of vitamin D and its analogues for treating thyroid cancer. The results suggest that Vitamin D deficiency may have value as a negative prognostic indicator in papillary thyroid cancer and that pre-operative laboratory evaluation may be less useful. This is important because Vitamin D deficiency is modifiable. Conclusions. In spite of large volume of medical literature from observational studies linking vitamin D with thyroid cancer, meaningful concrete clinical data on impact of vitamin D supplementation on hard clinical end points in these disorders is lacking, and should be the primary area of research in the next decade.

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Temporal and Geographical Trends of Incidence of Thyroid Cancer in Golestan, Iran, 2004-2013

Archives of Iranian Medicine ◽

10.34172/aim.2021.01 ◽

2021 ◽

Vol 24 (1) ◽

pp. 1-6

Author(s):

Fatemeh Salamat ◽

Ali Aryannia ◽

Siamak Rajaei ◽

Mohammad Naeimi-Tabiei ◽

Reza Afghani ◽

...

Keyword(s):

Thyroid Cancer ◽

Population Based ◽

Incidence Rates ◽

Common Type ◽

Cancer Data ◽

Significant Difference ◽

Golestan Province ◽

Males And Females ◽

The Mean ◽

Increasing Trends

Background: Thyroid cancer is the most common type of endocrine cancer. We aimed to determine the incidence rates of thyroid cancer across a 10-year period (2004-2013) in Golestan, Iran. Methods: We obtained the thyroid cancer data from Golestan Population-Based Cancer Registry (GPCR). Age-standardized incidence rates (ASR) were calculated and reported per 100000 person-years. The Joinpoint software was used to assess time trends, and average annual percent changes (AAPCs) and their corresponding 95% confidence intervals (CIs) were reported. Results: Of 326 registered patients, 83 (25.5%) were men and 243 (74.5%) were women. The mean age was 51.3 and 42.6 years for males and females, respectively. Overall, the ASR of thyroid cancer was 2.2 per 100000 person-year (AAPC = 2.76; 95% CI: -3.68 to 9.64). The test of co-incidence showed a statistically significant difference in the incidence of thyroid cancer between men (1.3) and women (3.2) (P < 0.001). According to our results, the ASR of thyroid cancer in western parts of Golestan is higher, including Gorgan and Aliabad cities. Conclusion: Increasing trends in incidence rates of thyroid cancer were found in the Golestan province during the study period, especially in women. We found significantly higher rates of thyroid cancer in women. Geographical diversities were seen in incidence rates of thyroid cancer in the Golestan province. Our results may be helpful for designing further researches to investigate the epidemiological aspects of thyroid cancer in the Golestan province.

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