Binding studies of ferrocene‐steroid conjugates with human serum albumin as potential drug carrier using fluorescence spectroscopy and in silico docking approach

2021 ◽  
Author(s):  
Xiomara Narváez‐Pita ◽  
Enrique Meléndez
Keyword(s):  
Human Serum Albumin ◽  
Fluorescence Spectroscopy ◽  
Serum Albumin ◽  
In Silico ◽  
Drug Carrier ◽  
Potential Drug ◽  
Binding Studies ◽  
In Silico Docking ◽  
Docking Approach ◽  
Steroid Conjugates

Evaluation of the biointeraction of colorant flavazin with human serum albumin: insights from multiple spectroscopic studies, in silico docking and molecular dynamics simulation

2014 ◽  
Vol 5 (6) ◽  
pp. 1203-1217 ◽  
Author(s):  
Wei Peng ◽  
Fei Ding ◽  
Yu-Ting Jiang ◽  
Ying Sun ◽  
Yu-Kui Peng
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Body ◽  
In Silico ◽  
Biological Activities ◽  
Spectroscopic Studies ◽  
Dynamics Simulation ◽  
In Silico Docking

The biological activities of azo colorant may significantly be influenced by the biointeraction of ligand to protein in the human body.

scholarly journals Fluorescence Spectroscopy and Molecular Docking Approach to Probe the Interaction between Dehydroeburicoic Acid and Human Serum Albumin

2019 ◽  
Vol 09 (01) ◽  
pp. 21-37 ◽  
Author(s):  
Shijie Zheng ◽  
Shude Yang ◽  
Xianhao Cheng ◽  
Tolgor Bau ◽  
Yu Li ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Human Serum Albumin ◽  
Fluorescence Spectroscopy ◽  
Serum Albumin ◽  
Human Serum ◽  
Docking Approach

scholarly journals Binding of porphyrin to human serum albumin. Structure–activity relationships

1990 ◽  
Vol 270 (2) ◽  
pp. 325-330 ◽  
Author(s):  
S Cohen ◽  
R Margalit
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Protein Binding ◽  
Human Serum ◽  
Binding Sites ◽  
Binding Constant ◽  
Drug Carrier ◽  
Haematoporphyrin Derivative ◽  
Binding Studies

The equilibrium binding of hydroxyethyl vinyl deuteroporphyrin (HVD) and of irreversible porphyrin aggregates to human serum albumin was studied at the molecular level. This protein may function as an endogenous drug carrier for porphyrins in photodynamic therapy of tumours. HVD-protein binding studies revealed two types of binding sites, which are attributed to the two HVD isomers. The binding constant for the high-affinity isomer, 2.1 (+/- 0.3) x 10(8) M-1, is similar to that previously determined for protoporphyrin. At the same time the binding constant for the lower-affinity HVD isomer, 1.8(+/- 0.3) x 10(6) M-1, is similar to that previously determined for haematoporphyrin. Irreversible porphyrin aggregates were purified from the haematoporphyrin derivative and from Photofrin and are defined by spectral and chromatographic data. Gel-exclusion studies indicate that the dominant size of these aggregates is ten porphyrin monomeric units. The protein-binding constant of these aggregates is 1.7(+/- 0.2) x 10(5) M-1, with four binding sites per protein molecule. The distinction between the HVD isomers along the porphyrin-protein affinity sequence gives insight into the relationship of porphyrin structure to porphyrin-albumin binding. On the basis of this study an evaluation of human serum albumin as an endogenous carrier for porphyrins (at various aggregation states) in photodynamic therapy of tumours is presented.

Mechanistic insight into the binding of graphene oxide with human serum albumin: Multispectroscopic and molecular docking approach

2021 ◽  
pp. 119750
Author(s):  
Afroz Khan ◽  
Fauzia Khan ◽  
Moyad Shahwan ◽  
Mohd Shahnawaz Khan ◽  
Fohad Mabood Husain ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Molecular Docking ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Mechanistic Insight ◽  
Docking Approach ◽  
Insight Into

Nof2206Probing the interaction of memantine, an important Alzheimer's drug, with human serum albumin: In silico and In vitro approach

2021 ◽  
pp. 116888
Author(s):  
Fahad A. Alhumaydhi ◽  
Mohammad Abdullah Aljasir ◽  
Abdullah S.M. Aljohani ◽  
Suliman A. Alsagaby ◽  
Ameen S.S. Alwashmi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Silico

Biophysical and in silico investigations of the molecular association between a potent RNA polymerase inhibitor, thiolutin and human serum albumin

2020 ◽  
Vol 303 ◽  
pp. 112648 ◽  
Author(s):  
Md. Zahirul Kabir ◽  
Zineddine Benbekhti ◽  
Nor Farrah Wahidah Ridzwan ◽  
Rabiâa Merrouche ◽  
Noureddine Bouras ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Rna Polymerase ◽  
Human Serum ◽  
In Silico ◽  
Molecular Association ◽  
Polymerase Inhibitor

Exploring the binding mechanism of Guaijaverin to human serum albumin: Fluorescence spectroscopy and computational approach

2012 ◽  
Vol 97 ◽  
pp. 449-455 ◽  
Author(s):  
Ícaro P. Caruso ◽  
Wagner Vilegas ◽  
Marcelo A. Fossey ◽  
Marinônio L. Cornélio
Keyword(s):  
Human Serum Albumin ◽  
Fluorescence Spectroscopy ◽  
Serum Albumin ◽  
Human Serum ◽  
Computational Approach ◽  
Binding Mechanism

In vitro and In silico Assessment of Human Serum Albumin Interactions with Omega 3-6-9 Fatty Acids

2022 ◽  
Author(s):  
F. M. Valojerdi ◽  
A. Farasat ◽  
N. Gheibi
Keyword(s):  
Fatty Acids ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
In Silico ◽  
Omega 3
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