Controlled release of nonionic compounds from poly(lactic acid)/cellulose nanocrystal nanocomposite fibers

2012 ◽  
Vol 127 (1) ◽  
pp. 79-86 ◽  
Author(s):  
Chunhui Xiang ◽  
Alan G. Taylor ◽  
Juan P. Hinestroza ◽  
Margaret W. Frey
Keyword(s):  
Lactic Acid ◽  
Controlled Release ◽  
Cellulose Nanocrystal ◽  
Poly Lactic Acid ◽  
Nanocomposite Fibers

Rheological and Thermo-Mechanical Properties of Poly(lactic acid)/Lignin-Coated Cellulose Nanocrystal Composites

2017 ◽  
Vol 5 (2) ◽  
pp. 1711-1720 ◽  
Author(s):  
Anju Gupta ◽  
William Simmons ◽  
Gregory T. Schueneman ◽  
Donald Hylton ◽  
Eric A. Mintz
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Cellulose Nanocrystal ◽  
Poly Lactic Acid

Synthesis and Kinetic Studies on Controlled Release of 6-Thioguanine Entrapped Polyethylene Glycol-Co-Polylactic Acid Polymer Nanoparticles

2011 ◽  
Vol 9 (1) ◽  
Author(s):  
Sathishkumar Kannaiyan ◽  
T.G.Ashwin Narayanan ◽  
P.Karthick Sarathy ◽  
Nagarjun Sudhakar ◽  
Rama Krishnan
Keyword(s):  
Gold Nanoparticles ◽  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Controlled Release ◽  
Drug Release ◽  
Kinetic Equations ◽  
Kinetic Studies ◽  
Poly Lactic Acid ◽  
Average Size

Poly lactic acid-polyethylene glycol (PLA-co-PEG) copolyester was synthesized from oligomer of L-lactic acid and poly ethylene glycol (PEG) using stannous octoate as catalyst. 6-Thioguanine containing Poly lactic acid-polyethylene glycol (PLA-co-PEG) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules changed substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm, respectively. In general the drug release was quicker in Phosphate buffer saline (pH 7.4) compared to 0.1M hydrochloric acid and this may be due to higher solubility, higher swelling and penetration properties of PLA-co-PEG in PBS compared to HCl. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency (75%) compared to that of polymer nanocapsules (45%) in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules. Application of in vitro drug release data to various kinetic equations indicated Higuchi model, indicating a uniform distribution of thioguanine in the nanocapsules.

Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

2014 ◽  
Vol 2 (20) ◽  
pp. 3133-3141 ◽  
Author(s):  
Claire Jouannin ◽  
Corine Tourné-Péteilh ◽  
Vincent Darcos ◽  
Tahmer Sharkawi ◽  
Jean-Marie Devoisselle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ionic Liquids ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

scholarly journals A comparative study of the mechanical, shape-memory, and degradation properties of poly(lactic acid) nanofiber and cellulose nanocrystal reinforced poly(mannitol sebacate) nanocomposites

RSC Advances ◽  
2017 ◽  
Vol 7 (35) ◽  
pp. 21869-21882 ◽  
Author(s):  
Águeda Sonseca ◽  
Olivia Menes ◽  
Enrique Giménez
Keyword(s):  
Lactic Acid ◽  
Comparative Study ◽  
Shape Memory ◽  
Mechanical Behaviour ◽  
Implantable Devices ◽  
Cellulose Nanocrystal ◽  
Poly Lactic Acid ◽  
Degradation Properties

Composites based on elastomeric matrices and with enhanced mechanical behaviour at physiological temperatures useful for shape memory biodegradable implantable devices.

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