Preparation a core‐shell lipid/polymer nanoparticle containing Isotretinoin drug with pH sensitive property: A response surface methodology study

2021 ◽  
pp. 50734
Author(s):  
Tahereh Najafi Ghaghelestani ◽  
Nafiseh Farhadian ◽  
Nafiseh Binesh
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ph Sensitive ◽  
Core Shell ◽  
Property A ◽  
Polymer Nanoparticle ◽  
Sensitive Property

Synthesis and Characterization of pH-Sensitive Genipin Cross-Linked Chitosan/Eudragit® L100 Hydrogel for Metformin Release Study Using Response Surface Methodology

2018 ◽  
Vol 15 (9) ◽  
pp. 1343-1358 ◽  
Author(s):  
Muhammad Ubaid ◽  
Syed Nisar Hussain Shah ◽  
Shujaat Ali Khan ◽  
Ghulam Murtaza
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Ph Sensitive ◽  
Synthesis And Characterization ◽  
Release Study

Optimization of microwave-assisted synthesis of high-quality ZnSe/ZnS core/shell quantum dots using response surface methodology

2013 ◽  
Vol 291 ◽  
pp. 476-481 ◽  
Author(s):  
Rong Ma ◽  
Pei-Jiang Zhou ◽  
Hong-Ju Zhan ◽  
Chi Chen ◽  
Yu-Ning He
Keyword(s):  
Quantum Dots ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Microwave Assisted Synthesis ◽  
Core Shell ◽  
High Quality ◽  
Microwave Assisted

An experimental study on the coaxial electrospinning of silk fibroin/poly(vinyl alcohol)–salicylic acid core-shell nanofibers and process optimization using response surface methodology

2017 ◽  
Vol 48 (5) ◽  
pp. 884-903 ◽  
Author(s):  
Nadia Rahimi Tanha ◽  
Mahdi Nouri
Keyword(s):  
Response Surface Methodology ◽  
Salicylic Acid ◽  
Electron Microscope ◽  
Response Surface ◽  
Release Rate ◽  
Vinyl Alcohol ◽  
Solution Concentration ◽  
Poly Vinyl Alcohol ◽  
Coaxial Electrospinning ◽  
Core Shell

Core-shell nanofiber of silk fibroin as shell and blend of salicylic acid/poly(vinyl alcohol) as core was fabricated successfully via coaxial electrospinning. Effects of concentration, viscosity, and electrical conductivity of the core and shell solutions on the final diameter of nanofibers and release behavior of salicylic acid were studied by viscometry, electrical conductometry, ultraviolet spectrophotometry, scanning electron microscope and transmission electron microscope methods. Response surface methodology was used to predict the relation between average fiber diameter as well as release rate of salicylic acid with core and shell concentrations. Direct relation between final nanofibers diameters and shell solution concentration was observed, while increase in core solution concentration was not significantly affected the final diameter of electrospun nanofibers. According to the results of release profiles, ratio of component in core and shell are effective parameters in rate and profile of salicylic acid release from these structures. Response surface methodology analysis indicates that the nanofibers diameters are more responsive to the changes in shell solution concentration and the release rate of salicylic acid is responsive to the changes in both shell and core solutions concentrations.

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