scholarly journals Review on the systems biology research of Yin‐deficiency‐heat syndrome in traditional Chinese medicine

2020 ◽  
Author(s):  
Ting‐Ting Jiang ◽  
Ji‐Cheng Li
Keyword(s):  
Systems Biology ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Yin Deficiency ◽  
Heat Syndrome ◽  
Biology Research

Kampo Medicine, Based on Traditional Medicine Theory, in Treating Uncured Glossodynia: Efficacy in Five Clinical Cases

2008 ◽  
Vol 36 (05) ◽  
pp. 835-847 ◽  
Author(s):  
Yasuyo Hijikata ◽  
Noriko Makiura ◽  
Takashi Kano ◽  
Kumi Higasa ◽  
Masahiko Shimizu ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Virus Infection ◽  
Yin Deficiency ◽  
Kidney Yang Deficiency ◽  
Qi Stagnation ◽  
Tcm Theory ◽  
Artificial Teeth ◽  
Heat Syndrome ◽  
Herbal Mixtures

Glossodynia, or tongue pain, is resistant to conventional therapies. Kampo medicines were evaluated in patients suffering from incurable glossodynia. Patients were diagnosed by traditional Chinese medicine (TCM) theory in order to determine the appropriate herbal prescriptions. Five Japanese females (50–76 years old) with glossodynia refractory to conventional therapy were enrolled in this study. Small portions of Rikkunshito, Jiinkokato, Hachimijiogan and Ryutanshakanto worked for a female diagnosed with "Spleen" and "Heart" Yin deficiency, "Kidney" Yang deficiency and "Liver" Qi stagnation producing heat syndrome. Seishoekkito and Bakumondoto were effective for a patient diagnosed with "Spleen Qi" deficiency and "Stomach" Yin deficiency producing heat syndrome. Rikkunshito, Kamikihito and Chikujountanto worked for a patient diagnosed with "Spleen Qi" and "Heart Yin" deficiency, stagnation of "Liver" Qi producing fire and "Gallbladder" Qi deficiency. Rokumijiogan, Kamishoyosan and Kambakutaisoto were effective for a patient with Yang rise based on Yin deficiency of "Kidney" and "Liver," and restless organ disorder based on Yin deficiency of 5 viscera. A patient diagnosed with "Spleen" Yang deficiency responded to a combination of Anchusan and Hangeshashinto. These patients with glossodynia had resolution of pain within 1 month of treatment. Herbal mixtures containing Ganoderam lucidum, not prescribed based on TCM theory, but effective for herpes virus infection, worked for a female suffering from glossodynia for 1 year after artificial teeth were placed, but required about 5 months to note improvement. Kampo medicines, properly prescribed based on TCM theory, quickly resolved the pain of refractory glossodynia.

Application of proteomics in the mechanistic study of traditional Chinese medicine

2011 ◽  
Vol 39 (5) ◽  
pp. 1348-1352 ◽  
Author(s):  
Xuan Liu ◽  
De-An Guo
Keyword(s):  
Systems Biology ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Mechanistic Study ◽  
Current Application ◽  
The Future

Systems biology is considered to be the possible technology that could bring breakthroughs in the study of TCM (traditional Chinese medicine). Proteomics, as one of the major components of systems biology, has been used in the mechanistic study of TCM, providing some interesting results. In the present paper, we review the current application of proteomics in the mechanistic study of TCM. Proteomics technologies and strategies that might be used in the future to improve study of TCM are also discussed.

Systems Biology Technologies Enable Personalized Traditional Chinese Medicine: A Systematic Review

2012 ◽  
Vol 40 (06) ◽  
pp. 1109-1122 ◽  
Author(s):  
Xijun Wang ◽  
Aihua Zhang ◽  
Hui Sun ◽  
Ping Wang
Keyword(s):  
Systems Biology ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Disease Diagnosis ◽  
Modern Medicine ◽  
Therapeutic Approaches ◽  
Current Trends ◽  
Close Relationship ◽  
The Right ◽  
Personalize Medicine

Traditional Chinese medicine (TCM), an alternative medicine, focuses on the treatment of human disease via the integrity of the close relationship between body and syndrome analysis. It remains a form of primary care in most Asian countries and its characteristics showcase the great advantages of personalized medicine. Although this approach to disease diagnosis, prognosis and treatment has served the medical establishment well for thousands of years, it has serious shortcomings in the era of modern medicine that stem from its reliance on reductionist principles of experimentation and analysis. In this way, systems biology offers the potential to personalize medicine, facilitating the provision of the right care to the right patient at the right time. We expect that systems biology will have a major impact on future personalized therapeutic approaches which herald the future of medicine. Here we summarize current trends and critically review the potential limitations and future prospects of such treatments. Some characteristic examples are presented to highlight the application of this groundbreaking platform to personalized TCM as well as some of the necessary milestones for moving systems biology of a state-of-the-art nature into mainstream health care.

scholarly journals Advancing Drug Discovery and Development from Active Constituents of Yinchenhao Tang, a Famous Traditional Chinese Medicine Formula

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Aihua Zhang ◽  
Hui Sun ◽  
Shi Qiu ◽  
Xijun Wang
Keyword(s):  
Systems Biology ◽  
Drug Discovery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanisms ◽  
Synergistic Effects ◽  
Molecular Networks ◽  
Agile Development ◽  
Therapeutic Effects ◽  
Systematic Analysis

Traditional Chinese medicine (TCM) formula has been playing a very important role in health protection and disease control for thousands of years. Guided by TCM syndrome theories, formula are designed to contain a combination of various kinds of crude drugs that, when combined, will achieve synergistic efficacy. However, the precise mechanism of synergistic action remains poorly understood. One example is a famous TCM formula Yinchenhao Tang (YCHT), whose efficacy in treating hepatic injury (HI) and Jaundice syndrome, has recently been well established as a case study. We also conducted a systematic analysis of synergistic effects of the principal compound using biochemistry, pharmacokinetics and systems biology, to explore the key molecular mechanisms. We had found that the three component (6,7-dimethylesculetin (D), geniposide (G), and rhein (R)) combination exerts a more robust synergistic effect than any one or two of the three individual compounds by hitting multiple targets. They can regulate molecular networks through activating both intrinsic and extrinsic pathways to synergistically cause intensified therapeutic effects. This paper provides an overview of the recent and potential developments of chemical fingerprinting coupled with systems biology advancing drug discovery towards more agile development of targeted combination therapies for the YCHT.

Traditional Chinese Medicine Typing of Affective Disorders and Treatment

1994 ◽  
Vol 22 (03n04) ◽  
pp. 321-327 ◽  
Author(s):  
Liang-dong Zhang ◽  
Ya-li Zhang ◽  
Shang-han Xu ◽  
Gang Zhou ◽  
Shu-bai Jin
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Affective Disorders ◽  
Marked Improvement ◽  
Yin Deficiency ◽  
In Fire

According to the theory of Traditional Chinese Medicine (TCM), 50 patients with affective disorders were typed into the categories of depressed liver resulting in fire, mild Yang deficiency and mild Yin deficiency and were treated with Xiao Yao San Jia Wei. The results are 26 patients with marked improvement, 17 patients with improvement and 7 patients with no improvement.

Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network

2010 ◽  
Vol 6 (4) ◽  
pp. 613 ◽  
Author(s):  
Tao Ma ◽  
Conge Tan ◽  
Hui Zhang ◽  
Miqu Wang ◽  
Weijun Ding ◽  
...  
Keyword(s):  
Systems Biology ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine

Understanding channel tropism in traditional Chinese medicine in the context of systems biology

2013 ◽  
Vol 7 (3) ◽  
pp. 277-279 ◽  
Author(s):  
Ping Liu ◽  
Songlin Liu ◽  
Gang Chen ◽  
Ping Wang
Keyword(s):  
Systems Biology ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine

Conjuctivitis Sicca: A Comparison of Traditional Chinese and Western Medical Symptoms

1994 ◽  
Vol 12 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Johannes Nepp ◽  
A Wedrich
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Medical Doctors ◽  
Autonomic Nervous ◽  
Yin Deficiency ◽  
Tcm Syndrome ◽  
Medical Symptoms ◽  
Conjunctivitis Sicca

In traditional Chinese medicine (TCM) three syndromes are said to be associated with conjunctivitis sicca: Liver-Yin deficiency, Liver-Yang excess and Liver fire. The diagnosis of one of these syndromes requires the use of a specific combination of points for acupuncture. We used an extensive questionnaire of autonomic nervous system disturbances to suggest points that should be treated on a western medical basis. This prospective study was performed to answer two questions: i. Is it possible to associate the complaints of our patients with a TCM syndrome? ii. Is there any difference between the results using a TCM combination of points and those selected with our western method? Thirty seven patients with conjunctivitis sicca were enrolled in the study and asked to complete two questionnaires. In one, autonomic nervous system complaints were evaluated; in the second, the symptoms of the three relevant TCM syndromes were specifically asked for. The results of both questionnaires were compared. Our “western medical” combination of points for therapy consisted of local points, and points related to the autonomic nervous system complaints and to the five Chinese elements. In total we recorded 29 different symptoms associated with conjunctivitis sicca. According to the TCM questionnaire, 21 patients had a deficit of Liver-Yin, 5 had a Liver-Yang excess and 10 suffered from Liver fire. One patient had symptoms of Liver-Yin and Liver-Yang. Yet all patients had symptoms of more than one Chinese syndrome. Only 4 out of 37 patients seemed to belong clearly to only one TCM syndrome. So the evaluation of symptoms according to the TCM system proved to be inadequate compared with the western “autonomic” system. Points for therapy resulting from the western system were similar to the points proposed by the TCM system. We conclude that the points proposed by both methods are similar for the treatment of conjunctivitis sicca, but we believe that for western medical doctors it is easier to find a successful combination of points with the western method asking about complaints of the autonomic nervous system.

scholarly journals Drug Design of Cyclin-Dependent Kinase 2 Inhibitor for Melanoma from Traditional Chinese Medicine

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Hsin-Chieh Tang ◽  
Calvin Yu-Chian Chen
Keyword(s):  
Cell Cycle ◽  
Molecular Dynamics ◽  
Support Vector Machine ◽  
Systems Biology ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Md Simulation ◽  
Support Vector ◽  
Cyclin Dependent Kinase ◽  
Melanoma Therapy

One has found an important cell cycle controller. This guard can decide the cell cycle toward proliferation or quiescence. Cyclin-dependent kinase 2 (CDK2) is a unique target among the CDK family in melanoma therapy. We attempted to find out TCM compounds from TCM Database@Taiwan that have the ability to inhibit the activity of CDK2 by systems biology. We selected Tetrahydropalmatine, Reserpiline, and (+)-Corydaline as the candidates by docking and screening results for further survey. We utilized support vector machine (SVM), multiple linear regression (MLR) models and Bayesian network for validation of predicted activity. By overall analysis of docking results, predicted activity, and molecular dynamics (MD) simulation, we could conclude that Tetrahydropalmatine, Reserpiline, and (+)-Corydaline had better binding affinity than the control. All of them had the ability to inhibit the activity of CDK2 and might have the opportunity to be applied in melanoma therapy.

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