scholarly journals Preparing for effective, adaptive risk communication about per‐ and polyfluoroalkyl substances in drinking water

2021 ◽  
Vol 3 (5) ◽  
Author(s):  
Melissa Harclerode ◽  
Sarah Baryluk ◽  
Heather Lanza ◽  
John Frangos
Keyword(s):  
Drinking Water ◽  
Risk Communication ◽  
Polyfluoroalkyl Substances

scholarly journals Immunotoxicity of Per- and Polyfluoroalkyl Substances: Insights into Short-Chain PFAS Exposure

Toxics ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 100
Author(s):  
Tracey Woodlief ◽  
Samuel Vance ◽  
Qing Hu ◽  
Jamie DeWitt
Keyword(s):  
Drinking Water ◽  
Nk Cell ◽  
Positive Control ◽  
Oral Exposure ◽  
Body Weights ◽  
Toxicological Data ◽  
Males And Females ◽  
Polyfluoroalkyl Substances ◽  
Compound Exposure ◽  
Control Terminal

Novel per- and polyfluoroalkyl substances (PFAS) were recently identified in drinking water sources throughout North Carolina. These include the perfluoroether acids (PFEAs) perfluoro-2-methoxyacetic acid (PFMOAA), perfluoro-2-methoxypropanoic acid (PFMOPrA), and perfluoro-4-methoxybutanioc acid (PFMOBA). Little toxicological data exist for these PFEAs. Therefore, the present study described signs of toxicity and immunotoxicity following oral exposure. Adult male and female C57BL/6 mice were exposed once/day for 30 days to PFMOAA (0, 0.00025, 0.025, or 2.5 mg/kg), PFMOPrA, or PFMOBA (0, 0.5, 5, or 50 mg/kg). A dose of 7.5 mg/kg of perfluorooctanoic acid (PFOA) was used as a positive control. Terminal body weights, and absolute liver, spleen, or thymus weights did not differ by dose for any compound; exposure to 50 mg/kg of PFMOBA increased relative liver weights in males. Changes in splenic cellularity were observed in males exposed to PFMOPrA and decreased numbers of B and natural killer (NK) cells were observed in males and females exposed to PFMOBA. Exposure did not alter NK cell cytotoxicity or T cell-dependent antibody responses at doses administered. Our results indicate that these “understudied” PFAS have toxicological potential but require additional investigation across endpoints and species, including humans, to understand health effects via drinking water exposure.

scholarly journals Effectiveness of point‐of‐use/point‐of‐entry systems to remove per‐ and polyfluoroalkyl substances from drinking water

2019 ◽  
Vol 1 (2) ◽  
pp. e1131 ◽  
Author(s):  
Craig Patterson ◽  
Jonathan Burkhardt ◽  
Donald Schupp ◽  
E. Radha Krishnan ◽  
Stephen Dyment ◽  
...  
Keyword(s):  
Drinking Water ◽  
Point Of Entry ◽  
Point Of Use ◽  
Polyfluoroalkyl Substances

Worldwide drinking water occurrence and levels of newly-identified perfluoroalkyl and polyfluoroalkyl substances

2018 ◽  
Vol 616-617 ◽  
pp. 1089-1100 ◽  
Author(s):  
Hermann A. Kaboré ◽  
Sung Vo Duy ◽  
Gabriel Munoz ◽  
Ladji Méité ◽  
Mélanie Desrosiers ◽  
...  
Keyword(s):  
Drinking Water ◽  
Polyfluoroalkyl Substances ◽  
Perfluoroalkyl And Polyfluoroalkyl Substances
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