Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

BioFactors ◽  
2013 ◽  
Vol 40 (1) ◽  
pp. 121-131 ◽  
Author(s):  
Paramasivan Poornima ◽  
Ching Feng Weng ◽  
Viswanadha Vijaya Padma
Keyword(s):  
Lung Cancer ◽  
Cell Cycle ◽  
Cell Growth ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Mapk Activation ◽  
Cycle Arrest ◽  
Seed Embryo

scholarly journals Atypical Protein Kinase Cι Plays a Critical Role in Human Lung Cancer Cell Growth and Tumorigenicity

2005 ◽  
Vol 280 (35) ◽  
pp. 31109-31115 ◽  
Author(s):  
Roderick P. Regala ◽  
Capella Weems ◽  
Lee Jamieson ◽  
John A. Copland ◽  
E. Aubrey Thompson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Protein Kinase ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Critical Role ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell

scholarly journals Inhibitory effects of norcantharidin against human lung cancer cell growth and migration

2010 ◽  
Vol 62 (4) ◽  
pp. 349-355 ◽  
Author(s):  
Jinling Luan ◽  
Huiying Duan ◽  
Qian Liu ◽  
Kazumi Yagasaki ◽  
Guoying Zhang
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Migration ◽  
And Migration

scholarly journals Targeting PRMT5/Akt signalling axis prevents human lung cancer cell growth

2018 ◽  
Vol 23 (2) ◽  
pp. 1333-1342 ◽  
Author(s):  
Shikui Zhang ◽  
Yaqiong Ma ◽  
Xiaoyan Hu ◽  
Yonghua Zheng ◽  
Xiaoke Chen
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell

Long non-coding RNA EPIC1 promotes human lung cancer cell growth

2018 ◽  
Vol 503 (3) ◽  
pp. 1342-1348 ◽  
Author(s):  
Bing Zhang ◽  
Hui-Yu Lu ◽  
Yun-Hong Xia ◽  
Ai-Gui Jiang ◽  
Yu-Xin Lv
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cell ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Beclin1-induced Autophagy Abrogates Radioresistance of Lung Cancer Cells by Suppressing Osteopontin

2012 ◽  
Vol 53 (3) ◽  
pp. 422-432 ◽  
Author(s):  
Seung-Hee Chang ◽  
Arash Minai-Tehrani ◽  
Ji-Young Shin ◽  
Sungjin Park ◽  
Ji-Eun Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Human Lung Cancer Cells

Abstract Osteopontin (OPN) serves as an indicator of resistance to radiotherapy. However, the role of OPN in the development of acquired radioresistance in human lung cancer cells has not yet been fully elucidated. Therefore, the potential importance of OPN as a marker of lung cancer with a potential significant role in the development of radioresistance against repeated radiotherapy has prompted us to define the pathways by which OPN regulates lung cancer cell growth. In addition, autophagy has been reported to play a key role in the radiosensitization of cancer cells. Here, we report that increased OPN expression through induction of nuclear p53 following irradiation was inhibited by exogenous beclin-1 (BECN1). Our results clearly show that BECN1 gene expression led to induction of autophagy and inhibition of cancer cell growth and angiogenesis. Our results suggest that the induction of autophagy abrogated the radioresistance of the cancer cells. Interestingly, we showed that knockdown of OPN by lentivirus-mediated shRNA induced the autophagy of human lung cancer cell. Taken together, these results suggest that OPN and BECN1 can be molecular targets for overcoming radioresistance by controlling autophagy.

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