Convective-diffusive mass transfer of agonist and the intracellular calcium response of endothelial cell

2008 ◽  
Vol 101 (4) ◽  
pp. 843-849 ◽  
Author(s):  
Vineet Kumar ◽  
S.N. Upadhyay
Keyword(s):  
Mass Transfer ◽  
Endothelial Cell ◽  
Intracellular Calcium ◽  
Calcium Response ◽  
Diffusive Mass Transfer

scholarly journals Exact solution of convective mass transfer model for Calcium response of endothelium

2000 ◽  
Vol 5 (5) ◽  
pp. 361-377
Author(s):  
Vineet Kumar ◽  
R. N. Pandey ◽  
S. N. Upadhyay
Keyword(s):  
Mass Transfer ◽  
Exact Solution ◽  
Endothelial Cells ◽  
Intracellular Calcium ◽  
Confluent Hypergeometric Function ◽  
Ion Concentration ◽  
Transfer Model ◽  
Mass Transfer Model ◽  
Calcium Response ◽  
Intracellular Calcium Ion

An exact solution for the concentration profile in tubes with surface reaction coupled with permeation have been obtained in terms of fast converging confluent hypergeometric function that gives accurate results. An excellent agreement between the experimental and theoretical results of the intracellular calcium ion concentration in the calf aorta endothelial cells and the extracellular ATP concentration provides yet another example in support of the mass transfer model for intracellular calcium response of the endothelial cells.

Presence of P2X1 Purinoceptors in Human Platelets and Megakaryoblastic Cell Lines

1997 ◽  
Vol 78 (06) ◽  
pp. 1500-1504 ◽  
Author(s):  
Catherine Vial ◽  
Béatrice Hechier ◽  
Catherine Léon ◽  
Jean-Pierre Cazenave ◽  
Christian Gachet
Keyword(s):  
Intracellular Calcium ◽  
G Proteins ◽  
Cell Lines ◽  
Calcium Influx ◽  
Human Platelets ◽  
P2y1 Receptor ◽  
Calcium Response ◽  
Ionotropic Receptors ◽  
External Calcium

SummaryHuman platelets are thought to possess at least two subtypes of purinoceptor, one of which, coupled to G-proteins, could be the P2Y1 receptor (Léon et al. 1997). However, it has been suggested that the unique rapid calcium influx induced by ADP in platelets could involve P2X1 ionotropic receptors (MacKenzie et al. 1996) and the aim of this study was thus to investigate the presence of P2X purinoceptors in platelets and megakaryoblastic cells. Using PCR experiments, we found P2X1 mRNA to be present in human platelets and megakaryoblastic cell lines. In platelets, the selective P2X1 agonist αβMeATP induced a rise in intracellular calcium only in the presence of external calcium and this effect was antagonized by suramin and PPADS. Repeated addition of a�MeATP desensitized the P2X1 purinoceptor but only slightly affected the ADP response, while no calcium response to αβMeATP was observed in megakaryoblastic cells. These results support the existence of functional P2X1 purinoceptors on human platelets and the presence of P2X1 transcripts in megakaryoblastic cell lines.

Diffusive mass transfer in island films

1978 ◽  
Vol 125 (7) ◽  
pp. 489-525 ◽  
Author(s):  
Ya.E. Geguzin ◽  
Yu.S. Kaganovskii
Keyword(s):  
Mass Transfer ◽  
Diffusive Mass Transfer ◽  
Island Films

Intracellular calcium response is reduced in CD4+ lymphocytes in Alzheimer's disease and in older persons with down's syndrome

1993 ◽  
Vol 14 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Angelika Grossmann ◽  
Walter A. Kukull ◽  
John C. Jinneman ◽  
Thomas D. Bird ◽  
Enrique C. Villacres ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intracellular Calcium ◽  
Older Persons ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Calcium Response ◽  
Cd4 Lymphocytes
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