Inhibitory Effects of 1-(5-Benzyl-4-(4-chlorophenyl)-2-methylfuran-3-yl)ethan-1-one on Allergic Inflammatory Responses in Rat Basophilic Leukemia Cells

2015 ◽  
Vol 36 (8) ◽  
pp. 2166-2169
Author(s):  
Gaeun Yoo ◽  
Sejin Ahn ◽  
Taeri Joe ◽  
Jaehyun Kim ◽  
Deug-Chan Lee
Keyword(s):  
Inflammatory Responses ◽  
Leukemia Cells ◽  
Inhibitory Effects ◽  
Rat Basophilic Leukemia Cells ◽  
Basophilic Leukemia

The distribution of antigen on the surface of RBL-2H3 rat basophilic leukemia cells observed by back-scattered electron imaging

1986 ◽  
Vol 44 ◽  
pp. 274-275
Author(s):  
R.F. Stump ◽  
J.R. Pfeiffer ◽  
JC. Seagrave ◽  
D. Huskisson ◽  
J.M. Oliver
Keyword(s):  
Cell Surface ◽  
Dynamic Properties ◽  
Leukemia Cells ◽  
Antigen Binding ◽  
Scattered Electron ◽  
Ige Receptor ◽  
Receptor Complexes ◽  
Rat Basophilic Leukemia Cells ◽  
Electron Imaging ◽  
Basophilic Leukemia

In RBL-2H3 rat basophilic leukemia cells, antigen binding to cell surface IgE-receptor complexes stimulates the release of inflammatory mediators and initiates a series of membrane and cytoskeletal events including a transformation of the cell surface from a microvillous to a lamellar topography. It is likely that dynamic properties of the IgE receptor contribute to the activation of these responses. Fewtrell and Metzger have established that limited crosslinking of IgE-receptor complexes is essential to trigger secretion. In addition, Baird and colleagues have reported that antigen binding causes a rapid immobilization of IgE-receptor complexes, and we have demonstrated an apparent increase with time in the affinity of IgE-receptor complexes for antigen.

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