scholarly journals Long non-coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA-106b-5p in seminoma

2018 ◽  
Vol 7 (12) ◽  
pp. 6247-6257 ◽  
Author(s):  
Jingchao Wei ◽  
Yu Gan ◽  
Dongyi Peng ◽  
Xianzhen Jiang ◽  
Riko Kitazawa ◽  
...  

2017 ◽  
Vol 16 (4) ◽  
pp. 4107-4112 ◽  
Author(s):  
Bin Liu ◽  
Chun-Feng Pan ◽  
Teng Ma ◽  
Jun Wang ◽  
Guo-Liang Yao ◽  
...  




Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3086
Author(s):  
Cong Zhou ◽  
Shiwei Duan

Studies have shown that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), play an important regulatory role in the occurrence and development of human cancer. Nicotinamide nucleotide transhydrogenase-antisense 1 (NNT-AS1) is a newly-discovered cytoplasmic lncRNA. Many studies have shown that it has abnormally-high expression levels in malignant tumors, but there are also a few studies that have reported low expression levels of NNT-AS1 in gastric cancer, breast cancer, and ovarian cancer. At present, the regulatory mechanism of NNT-AS1 as a miRNA sponge, which may be an important reason affecting tumor cell proliferation, invasion, metastasis, and apoptosis is being studied in-depth. In addition, NNT-AS1 has been found to be related to cisplatin resistance. In this review, we summarize the abnormal expression of NNT-AS1 in a variety of neoplastic diseases and its diagnostic and prognostic value, and we explain the mechanism by which NNT-AS1 regulates cancer progression by competing with miRNAs. In addition, we also reveal the correlation between NNT-AS1 and cisplatin resistance and the potential clinical applications of NNT-AS1.





Neoplasma ◽  
2015 ◽  
Vol 62 (03) ◽  
pp. 432-438 ◽  
Author(s):  
F. WANG ◽  
J. ZHOU ◽  
X. XIE ◽  
J. HU ◽  
L. CHEN ◽  
...  


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