Supramolecular Interaction of Molecular Cage and β‐Galactosidase: Application in Enzymatic Inhibition, Drug Delivery and Antimicrobial Activity

The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class...

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Benzoyl Peroxide In Situ Forming Antimicrobial Gel for Periodontitis Treatment

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.545.63 ◽

2013 ◽

Vol 545 ◽

pp. 63-68 ◽

Cited By ~ 8

Author(s):

Jongjan Mahadlek ◽

Juree Charoenteeraboon ◽

Thawatchai Phaechamud

Keyword(s):

Drug Delivery ◽

Antimicrobial Activity ◽

Drug Release ◽

Delivery System ◽

Periodontal Pocket ◽

Peppermint Oil ◽

In Situ Gel ◽

In Situ Forming ◽

In Situ Forming Gel

Periodontitis is an inflammatory disease of the supporting structures of the tooth caused by bacterial infection which can result in tooth loss. The local intra-pocket drug delivery system was interesting and highly effective for periodontitis treatment. In situ forming gel system is the polymeric solution which could transform into gel for localizing and sustaining the drug release at desired site. This system has been recommended as one of suitable delivery system for this purpose. Benzoyl peroxide (BPO) in situ forming gels were developed using Eudragit RS as polymer dispersed in N-methyl-pyrrolidone (NMP). Peppermint oil and polyethylene glycol 1500 were also incorporated as the excipients. The prepared systems were evaluated for rheology, syringeability (using texture analyzers), in situ gel formation (after injection into PBS pH 6.8), antimicrobial activity (against Streptococcus mutans with agar diffusion) and drug release (with dialysis method in PBS pH 6.8 at 50 rpm, 37 °C). The viscosity and syringeability of the prepared systems was increased as the amount of BPO, peppermint oil or PEG 1500 was increased. All prepared gels showed the Newtonian flow which the viscosity was decreased as the temperature was increased. All prepared gels comprising peppermint oil and PEG 1500 could form in situ gel in used medium which the pH was close to the environment pH of periodontal pocket. The inhibition zone against Streptococcus mutans of the prepared system was significantly decreased when the peppermint oil and PEG 1500 was incorporated owing to the higher viscous environment and thereafter retardation of drug diffusion was evident. This effect could prolong the drug release. From drug release test, all prepared gels could sustain the BPO release for at least 96 hrs. Release kinetic obtained from curve fitting with various release equations using least square fit technique indicated that the release patterns were as Higuchi’s model therefore the release of BPO was performed with diffusion control. This developed BPO in situ forming gel presented its ability as the controlled drug delivery system for localized antimicrobial activity at periodontal pocket.

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Class I and II Bacteriocins: Structure, Biosynthesis and Drug Delivery Systems for the Improvement of their Antimicrobial Activity

Current Proteomics ◽

10.2174/157016461102140917122421 ◽

2014 ◽

Vol 11 (2) ◽

pp. 121-127 ◽

Cited By ~ 2

Author(s):

Lia-Mara Ditu ◽

Mariana Chifiriuc ◽

Diana Pelinescu ◽

Ionela Avram ◽

Gratiela Pircalabioru ◽

...

Keyword(s):

Drug Delivery ◽

Antimicrobial Activity ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Class I

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Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

International Journal of Nanomedicine ◽

10.2147/ijn.s127715 ◽

2017 ◽

Vol Volume 12 ◽

pp. 1201-1214 ◽

Cited By ~ 21

Author(s):

Yang Zhang ◽

Ruo-jia Liang ◽

Jiao-jiao Xu ◽

Li-feng Shen ◽

Jian-qing Gao ◽

...

Keyword(s):

Drug Delivery ◽

Antimicrobial Activity ◽

Drug Delivery System ◽

Delivery System ◽

Trimethylene Carbonate ◽

Efficient Induction ◽

Localized Drug Delivery

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Nanocellulose in Drug Delivery and Antimicrobially Active Materials

Polymers ◽

10.3390/polym12122825 ◽

2020 ◽

Vol 12 (12) ◽

pp. 2825

Author(s):

Kaja Kupnik ◽

Mateja Primožič ◽

Vanja Kokol ◽

Maja Leitgeb

Keyword(s):

Drug Delivery ◽

Antimicrobial Activity ◽

Sustained Release ◽

Drug Delivery Systems ◽

Antimicrobial Agents ◽

Metal Oxide Nanoparticles ◽

Biological Properties ◽

Oxide Nanoparticles ◽

Active Materials ◽

Natural Sources

In recent years, nanocellulose (NC) has also attracted a great deal of attention in drug delivery systems due to its unique physical properties, specific surface area, low risk of cytotoxicity, and excellent biological properties. This review is focused on nanocellulose based systems acting as carriers to be used in drug or antimicrobial delivery by providing different but controlled and sustained release of drugs or antimicrobial agents, respectively, thus showing potential for different routes of applications and administration. Microorganisms are increasingly resistant to antibiotics, and because, generally, the used metal or metal oxide nanoparticles at some concentration have toxic effects, more research has focused on finding biocompatible antimicrobial agents that have been obtained from natural sources. Our review contains the latest research from the last five years that tested nanocellulose-based materials in the field of drug delivery and antimicrobial activity.

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