Nanocellulose in Drug Delivery and Antimicrobially Active Materials

In recent years, nanocellulose (NC) has also attracted a great deal of attention in drug delivery systems due to its unique physical properties, specific surface area, low risk of cytotoxicity, and excellent biological properties. This review is focused on nanocellulose based systems acting as carriers to be used in drug or antimicrobial delivery by providing different but controlled and sustained release of drugs or antimicrobial agents, respectively, thus showing potential for different routes of applications and administration. Microorganisms are increasingly resistant to antibiotics, and because, generally, the used metal or metal oxide nanoparticles at some concentration have toxic effects, more research has focused on finding biocompatible antimicrobial agents that have been obtained from natural sources. Our review contains the latest research from the last five years that tested nanocellulose-based materials in the field of drug delivery and antimicrobial activity.

Download Full-text

Antimicrobial metal-based nanoparticles: a review on their synthesis, types and antimicrobial action

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.11.129 ◽

2020 ◽

Vol 11 ◽

pp. 1450-1469

Author(s):

Matías Guerrero Correa ◽

Fernanda B Martínez ◽

Cristian Patiño Vidal ◽

Camilo Streitt ◽

Juan Escrig ◽

...

Keyword(s):

Antimicrobial Activity ◽

Food Packaging ◽

Antimicrobial Agents ◽

Cell Damage ◽

Metal Oxide Nanoparticles ◽

High Surface ◽

Antimicrobial Properties ◽

Antimicrobial Action ◽

Oxide Nanoparticles ◽

Synthesis Methods

The investigation of novel nanoparticles with antimicrobial activity has grown in recent years due to the increased incidence of nosocomial infections occurring during hospitalization and food poisoning derived from foodborne pathogens. Antimicrobial agents are necessary in various fields in which biological contamination occurs. For example, in food packaging they are used to control food contamination by microbes, in the medical field the microbial agents are important for reducing the risk of contamination in invasive and routine interventions, and in the textile industry, they can limit the growth of microorganisms due to sweat. The combination of nanotechnology with materials that have an intrinsic antimicrobial activity can result in the development of novel antimicrobial substances. Specifically, metal-based nanoparticles have attracted much interest due to their broad effectiveness against pathogenic microorganisms due to their high surface area and high reactivity. The aim of this review was to explore the state-of-the-art in metal-based nanoparticles, focusing on their synthesis methods, types, and their antimicrobial action. Different techniques used to synthesize metal-based nanoparticles were discussed, including chemical and physical methods and “green synthesis” methods that are free of chemical agents. Although the most studied nanoparticles with antimicrobial properties are metallic or metal-oxide nanoparticles, other types of nanoparticles, such as superparamagnetic iron-oxide nanoparticles and silica-releasing systems also exhibit antimicrobial properties. Finally, since the quantification and understanding of the antimicrobial action of metal-based nanoparticles are key topics, several methods for evaluating in vitro antimicrobial activity and the most common antimicrobial mechanisms (e.g., cell damage and changes in the expression of metabolic genes) were discussed in this review.

Download Full-text

Wide band-gap oxide nanoparticles as potential drug carriers

Medycyna Weterynaryjna ◽

10.21521/mw.5783 ◽

2017 ◽

Vol 73 (10) ◽

pp. 657-660 ◽

Cited By ~ 1

Author(s):

Waldemar Lipiński ◽

Jarosław Kaszewski ◽

Zdzisław Gajewski ◽

Marek Godlewski ◽

Michał M. Godlewski

Keyword(s):

Drug Delivery ◽

Band Gap ◽

Drug Delivery Systems ◽

Rapid Development ◽

Metal Oxide Nanoparticles ◽

Wide Band ◽

Drug Carriers ◽

Delivery Systems ◽

Oxide Nanoparticles ◽

Wide Band Gap

Recent decades have brought rapid development in the field of nanotechnology, which has led to applications of nanoparticles in many industries. Unique properties of nanoparticles and their biocompatibility increase their potential as drug carriers in drug-delivery systems. Prof. Marek Godlewski’s team from the Institute of Physics PAS has developed wide band-gap metal oxide nanoparticles doped with rare-earth metals for applications as fluorescent markers. The potential of those nanoparticles to cross the closed gut barrier after alimentary application has prompted their use in drug delivery systems. In this study, we show that after conjugation with a model bioactive substance, lectin (Phaseolus vulgaris), these nanoparticles retained their advantageous properties and, following oral administration (10 mg/ml in RO, 0.3 ml/mouse), entered a variety of organs in the mouse model. Internal organs collected at key time points were analysed under a scanning cytometer and a confocal microscope. The results show that the conjugation reduced, but did not completely abolish, the capacity of nanoparticles to penetrate physiological barriers (intestinal, blood-brain barrier) in the organism.

Download Full-text

Metal Oxide Nanomaterials

10.20850/9781716360367 ◽

2020 ◽

Author(s):

Nandini Roy ◽

Utshab Singha ◽

Saurav Paul ◽

Gaurav Kumar Pushp ◽

Swagat Bardoloi ◽

...

Keyword(s):

Drug Delivery ◽

Metal Oxide ◽

Zinc Oxide Nanoparticles ◽

Drug Delivery Systems ◽

Metal Oxide Nanoparticles ◽

Engineered Nanoparticles ◽

Oxide Nanoparticles ◽

Important Class ◽

Biological Applications ◽

Metal Oxide Nanomaterials

Engineered nanoparticles have been used widely in various sectors such as electronics, construction, health, energy, remediation and agriculture etc. In recent years, Metal oxide nanoparticles have become one of the important class of materials for both material and biological applications. For instance, Zinc oxide Nanoparticles has its effective bioapplications in various fields including pharmaceuticals, medicines, and agriculture. At the same time, these are of high important due to their utilization in biosensors, cosmetics, drug-delivery systems etc. This book documents some important aspects of metal oxide nanomaterials highlighting their material, environmental and biological prospects.

Download Full-text

Design, Development and Evaluation of Chronomodulated Drug Delivery Systems of Amoxicillin Trihydrate with Enhanced Antimicrobial Activity

Current Drug Delivery ◽

10.2174/1567201811310020004 ◽

2013 ◽

Vol 10 (2) ◽

pp. 174-187 ◽

Cited By ~ 4

Author(s):

Sarwar Beg ◽

Suryakanta Swain ◽

Sachin Gahoi ◽

Kanchan Kohli

Keyword(s):

Drug Delivery ◽

Antimicrobial Activity ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Design Development ◽

Amoxicillin Trihydrate

Download Full-text

Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin

Current Nanomaterials ◽

10.2174/2405461505999200917122147 ◽

2020 ◽

Vol 5 (3) ◽

pp. 224-235

Author(s):

Harshal A. Pawar ◽

Bhagyashree D. Bhangale

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery Systems ◽

Biological Activities ◽

Curcuma Longa ◽

Research Work ◽

Elimination Rate ◽

Delivery Systems ◽

Physicochemical Stability ◽

Wide Range

Background: Lipid based excipients have increased acceptance nowadays in the development of novel drug delivery systems in order to improve their pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability due to the protection they experience in the lipid core of these nano-formulations. Phytosomes are newly discovered drug delivery systems and novel botanical formulation to produce lipophilic molecular complex which imparts stability, increases absorption and bioavailability of phytoconstituent. Curcumin, obtained from turmeric (Curcuma longa), has a wide range of biological activities. The poor solubility and wettability of curcumin are responsible for poor dissolution and this, in turn, results in poor bioavailability. To overcome these limitations, the curcumin-loaded nano phytosomes were developed to improve its physicochemical stability and bioavailability. Objective: The objective of the present research work was to develop nano-phytosomes of curcumin to improve its physicochemical stability and bioavailability. Methods: Curcumin-loaded nano phytosomes were prepared by using phospholipid Phospholipon 90 H using a modified solvent evaporation method. The developed curcumin nano phytosomes were evaluated by particle size analyzer and differential scanning calorimetry (DSC). Results: Results indicated that phytosomes prepared using curcumin and lipid in the ratio of 1:2 show good entrapment efficiency. The obtained curcumin phytosomes were spherical in shape with a size less than 100 nm. The prepared nano phytosomal formulation of curcumin showed promising potential as an antioxidant. Conclusion: The phytosomal complex showed sustained release of curcumin from vesicles. The sustained release of curcumin from phytosome may improve its absorption and lowers the elimination rate with an increase in bioavailability.

Download Full-text

Formulation and characterization of novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for sustained release of simvastatin

Journal of Drug Delivery Science and Technology ◽

10.1016/j.jddst.2019.101222 ◽

2019 ◽

Vol 53 ◽

pp. 101222 ◽

Cited By ~ 2

Author(s):

Zora Ćetković ◽

Sandra Cvijić ◽

Dragana Vasiljević

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery Systems ◽

Delivery Systems

Download Full-text

Antiviral Activity of Carrageenans and Processing Implications

Marine Drugs ◽

10.3390/md19080437 ◽

2021 ◽

Vol 19 (8) ◽

pp. 437

Author(s):

Milena Álvarez-Viñas ◽

Sandra Souto ◽

Noelia Flórez-Fernández ◽

Maria Dolores Torres ◽

Isabel Bandín ◽

...

Keyword(s):

Drug Delivery ◽

Antiviral Activity ◽

Drug Delivery Systems ◽

Biological Properties ◽

Red Seaweed ◽

Processing Conditions ◽

Chemical Modifications ◽

Viral Attachment ◽

Extraction Stage ◽

Composition Structure

Carrageenan and carrageenan oligosaccharides are red seaweed sulfated carbohydrates with well-known antiviral properties, mainly through the blocking of the viral attachment stage. They also exhibit other interesting biological properties and can be used to prepare different drug delivery systems for controlled administration. The most active forms are λ-, ι-, and κ-carrageenans, the degree and sulfation position being determined in their properties. They can be obtained from sustainable worldwide available resources and the influence of manufacturing on composition, structure, and antiviral properties should be considered. This review presents a survey of the antiviral properties of carrageenan in relation to the processing conditions, particularly those assisted by intensification technologies during the extraction stage, and discusses the possibility of further chemical modifications.

Download Full-text