Oxidative stress in cancer therapy: Friend or enemy?

ChemBioChem ◽  
2022 ◽  
Author(s):  
Maria Azmanova ◽  
Anaïs Pitto-Barry
Keyword(s):  
Oxidative Stress ◽  
Cancer Therapy

Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy

2020 ◽  
Vol 27 (13) ◽  
pp. 2118-2132 ◽  
Author(s):  
Aysegul Hanikoglu ◽  
Hakan Ozben ◽  
Ferhat Hanikoglu ◽  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Drug Resistance ◽  
Side Effects ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Anticancer Drugs ◽  
Chemotherapeutic Agents ◽  
Oxidation Reactions ◽  
Hybrid Compounds ◽  
Induced Apoptosis

: Elevated Reactive Oxygen Species (ROS) generated by the conventional cancer therapies and the endogenous production of ROS have been observed in various types of cancers. In contrast to the harmful effects of oxidative stress in different pathologies other than cancer, ROS can speed anti-tumorigenic signaling and cause apoptosis of tumor cells via oxidative stress as demonstrated in several studies. The primary actions of antioxidants in cells are to provide a redox balance between reduction-oxidation reactions. Antioxidants in tumor cells can scavenge excess ROS, causing resistance to ROS induced apoptosis. Various chemotherapeutic drugs, in their clinical use, have evoked drug resistance and serious side effects. Consequently, drugs having single-targets are not able to provide an effective cancer therapy. Recently, developed hybrid anticancer drugs promise great therapeutic advantages due to their capacity to overcome the limitations encountered with conventional chemotherapeutic agents. Hybrid compounds have advantages in comparison to the single cancer drugs which have usually low solubility, adverse side effects, and drug resistance. This review addresses two important treatments strategies in cancer therapy: oxidative stress induced apoptosis and hybrid anticancer drugs.

Antioxidant Nanomedicine Significantly Enhances the Survival Benefit of Radiation Cancer Therapy by Mitigating Oxidative Stress‐Induced Side Effects

Small ◽  
2021 ◽  
pp. 2008210
Author(s):  
Ahram Kim ◽  
Chiaki Yonemoto ◽  
Chitho P. Feliciano ◽  
Babita Shashni ◽  
Yukio Nagasaki
Keyword(s):  
Oxidative Stress ◽  
Side Effects ◽  
Cancer Therapy ◽  
Survival Benefit

Redox-Active Quinones and Ascorbate: An Innovative Cancer Therapy That Exploits the Vulnerability of Cancer Cells to Oxidative Stress

2011 ◽  
Vol 11 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Julien Verrax ◽  
Raphael Beck ◽  
Nicolas Dejeans ◽  
Christophe Glorieux ◽  
Brice Sid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Redox Active

Curcumin, Oxidative Stress, and Cancer Therapy

2011 ◽  
pp. 233-256 ◽  
Author(s):  
Heather C. Hatcher ◽  
Frank M. Torti ◽  
Suzy V. Torti
Keyword(s):  
Oxidative Stress ◽  
Cancer Therapy

Tumor Microenvironment-Responsive, Multistaged Liposome Induces Apoptosis and Ferroptosis by Amplifying Oxidative Stress for Enhanced Cancer Therapy

2020 ◽  
Vol 12 (27) ◽  
pp. 30031-30043 ◽  
Author(s):  
Longfa Kou ◽  
Rui Sun ◽  
Xinyu Jiang ◽  
Xinlu Lin ◽  
Huirong Huang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Tumor Microenvironment ◽  
Cancer Therapy

scholarly journals Glucose deprivation-induced metabolic oxidative stress and cancer therapy

2009 ◽  
Vol 5 (9) ◽  
pp. 2 ◽  
Author(s):  
DouglasR Spitz ◽  
AndreanL Simons ◽  
DavidM Mattson ◽  
Ken Dornfeld
Keyword(s):  
Oxidative Stress ◽  
Cancer Therapy ◽  
Glucose Deprivation ◽  
Metabolic Oxidative Stress

scholarly journals Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-2 ◽  
Author(s):  
Lynne Postovit ◽  
Christian Widmann ◽  
Peng Huang ◽  
Spencer B. Gibson
Keyword(s):  
Oxidative Stress ◽  
Cancer Therapy

Oxidative stress and apoptosis: Impact on cancer therapy

2007 ◽  
Vol 96 (9) ◽  
pp. 2181-2196 ◽  
Author(s):  
Tomris Ozben
Keyword(s):  
Oxidative Stress ◽  
Cancer Therapy
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